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Charles J. Lowenstein, M.D.

Cardiology

Clinical Interests

General Cardiology

Contact Information

Phone Numbers

Appointment: (585) 341-7700

Administrative: (585) 275-2756

Office: (585) 275-2756

Fax: (585) 276-1530

URMFGA member of the University of Rochester Medical Faculty Group

groupAn Accountable Health Partner

assignmentAccepting New Patients

Research Labs

Lab: (585) 276-7723

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Biography

Charles J. Lowenstein, M.D. is Chief of Cardiology at the University of Rochester School of Medicine and Dentistry. Dr. Lowenstein works with patients in the outpatient cardiology office treating cardiovascular diseases such as hypertension and hyperlipidemia. He is board certified in internal medicine and cardiovascular disease.

Professional Background

Charles J. Lowenstein, M.D. is Professor of Medicine, Chief of Cardiology, and Director of the Cardiovascular Research Institute at the University of Rochester School of Medicine and Dentistry. Dr. Lowenstein obtained his M.D. at the Harvard Medical School. He completed his medical residency at The Massachusetts General Hospital and his cardiology fellowship at The Johns Hopkins University School of Medicine. He became Chief of Cardiology at the University of Rochester Medical Center in 2009. He has served on the NIH Atherosclerosis and Inflammation Cardiovascular Sciences study section. He is a member of the Sarnoff Cardiovascular Research Foundation, an organization that funds medical student research.

Research

Dr. Lowenstein's research is focused on vascular biology. One team or researchers explores mechanisms of exocytosis, through which endothelial cells release pro-inflammatory and pro-thrombotic mediators. A second group of scientists study how platelets communicate with endothelial cells. A third area of research involves an exploration of the role of microRNA in endothelial cells. A fourth team investigates how nitric oxide affects vascular inflammation.

Credentials

Faculty Appointments

Specialties

  • Cardiovascular Disease - American Board of Internal Medicine
  • Internal Medicine - American Board of Internal Medicine

Education

1982
BA | Harvard University
Biochemistry

1986
MD | Harvard Medical School
Medicine

1986-1989
| Massachusetts General Hospital
Medical Resident

1989-1990
| Massachusetts General Hospital
Research and Clinical Fellow

1989-1990
| Massachusetts Institute of Technology
Research Fellow

1991-1994
| The Johns Hopkins University School of Medicine
Cardiology Fellow

Post-doctoral Training & Residency

07/01/1986 - 06/30/1987
Internship in Internal Medicine at Massachusetts General Hospital

07/01/1987 - 06/30/1989
Residency in Internal Medicine at Massachusetts General Hospital

01/01/1991 - 06/30/1993
Fellowship in Internal Medicine: Cardiovascular Disease at Johns Hopkins Hospital - GME Office

07/01/1989 - 12/31/1990
Research in at Massachusetts General Hospital

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Awards

2007 - 2007
Member
Sponsor: InterUrban Clinical Club
Location: Baltimore, MD

2005 - 2005
Peter Dolphin Award
Sponsor: Pfizer
Location: Paris, France

2003 - 2003
Sir William Osler Young Investigator Award
Sponsor: Interurban Clinical Club
Location: Baltimore, MD

2002 - 2002
Member
Sponsor: American Society for Clinical Investigation

2000 - 2000
Young Investigators Conference on Atherosclerosis Award
Sponsor: Merck, Inc.
Location: New York, NY

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Publications

Journal Articles

10/2017
Bruckel J, Mehta A, Bradley SM, Thomas S, Lowenstein CJ, Nallamothu BK, Walkey AJ. "Variation in Do-Not-Resuscitate Orders and Implications for Heart Failure Risk-Adjusted Hospital Mortality Metrics." JACC. Heart failure.. 2017 Oct 0; 5(10):743-752.

4/2017
Croft DP, Cameron SJ, Morrell CN, Lowenstein CJ, Ling F, Zareba W, Hopke PK, Utell MJ, Thurston SW, Thevenet-Morrison K, Evans KA, Chalupa D, Rich DQ. "Associations between ambient wood smoke and other particulate pollutants and biomarkers of systemic inflammation, coagulation and thrombosis in cardiac patients." Environmental research.. 2017 Apr 0; 154:352-361. Epub 2017 Feb 04.

2/2017
Zhu QM, Ko KA, Ture S, Mastrangelo MA, Chen MH, Johnson AD, O'Donnell CJ, Morrell CN, Miano JM, Lowenstein CJ. "Novel Thrombotic Function of a Human SNP in STXBP5 Revealed by CRISPR/Cas9 Gene Editing in Mice." Arteriosclerosis, thrombosis, and vascular biology.. 2017 Feb 0; 37(2):264-270. Epub 2016 Dec 29.

Books & Chapters

2009
Book Title: The Role of Nitric Oxide in Myocarditis
Author List: Lowenstein, C.J. and Sun, H.
Edited By: Giles, T.D., Given, M., Greenberg, S.S.
Published By: Springer Verlag2009

2008
Chapter Title: Exocytosis of Endothelial Cells is Regulated by N-ethylmaleimide Sensitive Factor
Book Title: Methods in Molecular Biology
Author List: Yamakuchi, M., Ferlito, M., Morrell, C.n., Matsushita, K., Fletcher, C.A., Cao, W., and Lowenstein, C.J.
Edited By: Andrei Ivanov
Published By: Humana Press2008 in Totowa, NJ

2007
Chapter Title: Weibel-Palade Bodies: Vesicular Trafficking on the Vascular Highway
Book Title: The Endothelium: A Comprehensive Reference
Author List: Lowenstein, C.J.
Published By: Cambridge University Press2007

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Videos

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Heart Disease Hides in Seemingly Healthy Youngsters