Dr. Sen received his undergraduate degree in Microbiology with minor in Chemistry and Zoology from Bangalore University in 2000 followed by Masters degree in 2002 in Biochemistry from University of Calcutta, India. Thereafter he joined the PhD program in Cell and Molecular Biology at West Virginia University, where he worked with Dr. Jorge Flores and Dr. Keith Inskeep. His PhD work focused on the intracellular mechanisms regulating the functions of corpus luteum, a transient endocrine gland that plays a vital role in the reproduction by supporting pregnancy. Following his PhD in 2005, Dr. Sen moved to Michigan State University for a post-doctoral fellowship in the Department of Animal Sciences.
At MSU, he worked with Dr. George Smith and Dr. James Ireland on the role of a novel neuropeptide called Cocaine-and Amphetamine-Regulated Transcript (CART) on follicular development. Dr. Sen was also part of a research team that discovered a novel oocyte specific protein, JY-1 involved in early embryonic development. In 2008, Dr. Sen joined the laboratory of Dr. Stephen R Hammes in the Division of Endocrinology and Metabolism at University of Texas Southwestern Medical Center, Dallas first as a post-doctoral fellow and then in 2009 he moved from Dallas to University of Rochester Medical Center. Dr. Sen is currently working as a Research Assistant Professor in the Division of Endocrinology and Metabolism at University of Rochester. Dr. Sen's research focuses on three closely related but distinct areas: (1) Understanding the role of androgens in ovarian physiology, (2) Mechanism of steroid actions in cancer development and progression, and (3) Determining local effects of obesity on ovarian function and identifying biomarkers for obesity related fertility problems.
My research interests are focused towards understanding how various factors like steroid hormones, intra-follicular proteins and gonadotropins regulate ovarian physiology, specifically follicular development in normal and patho-physiological conditions affecting female fertility. My present research encompasses 2 projects:
Androgen signaling in ovarian development and function: Androgens have long been referred to as the "male" hormone and almost universally were considered detrimental to normal folliculogenesis, and elevated androgens in women have been associated with poor health and reduced fertility. Interestingly, in recent years, our studies have helped in putting forth a new concept suggesting that sufficient androgen signaling through the androgen receptor (AR) is necessary for normal follicle development and function. We have developed an ovary-specific AR knockout mouse model to determine the role of granulosa cell-specific ARs in follicular development and female fertility. Another major effort of my research is to determine the intra-cellular mechanism of androgens and how it regulates ovarian physiology and female fertility in normal and patho-physiological conditions like pre-mature ovarian failure (POF) or diminished ovarian reserve (DOR). In recent years the use of androgen treatments in women with DOR or POF has become highly popular across the world. Thus, through collaboration with IVF clinicians we are now extending our observations in the mouse to a clinical setting.
My second research project involves in understanding ovarian effects of obesity and its contribution to female sub-fertility or infertility. I am specifically interested in identifying local intra-follicular regulatory molecules, their cognate signaling pathways and their respective actions affecting ovarian function under obese conditions. We have identified a novel intra-cellular mechanism of action for leptin in the ovary that accounts for most of leptin's known negative effects of obesity on ovarian function. Using transgenic mouse models and human samples our aim is to develop a potential biomarker for obesity-related fertility problems that has predictive value for in vitro fertilization (IVF) outcomes in obese patients.