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Aram Francis Hezel, M.D.



Showing all 38 journal articles & 0 books available

Journal Articles

Saha SK, Parachoniak CA, Ghanta KS, Fitamant J, Ross KN, Najem MS, Gurumurthy S, Akbay EA, Sia D, Cornella H, Miltiadous O, Walesky C, Deshpande V, Zhu AX, Hezel AF, Yen KE, Straley KS, Travins J, Popovici-Muller J, Gliser C, Ferrone CR, Apte U, Llovet JM, Wong KK, Ramaswamy S, Bardeesy N. "Mutant IDH inhibits HNF-4? to block hepatocyte differentiation and promote biliary cancer." Nature. 2014; 10.1038/nature13441.

Hezel AF, Noel MS, Allen JN, Abrams TA, Yurgelun M, Faris JE, Goyal L, Clark JW, Blaszkowsky LS, Murphy JE, Zheng H, Khorana AA, Connolly GC, Hyrien O, Baran A, Herr M, Ng K, Sheehan S, Harris DJ, Regan E, Borger DR, Iafrate AJ, Fuchs C, Ryan DP, Zhu AX. "Phase II study of gemcitabine, oxaliplatin in combination with panitumumab in KRAS wild-type unresectable or metastatic biliary tract and gallbladder cancer. ." Br J Cancer.;111(3):430-6. doi: 10.1038/bjc.2014.343. Epub 2014 Jun 24. 2014; .

Connolly GC, Safadjou S, Kashyap R, Chen R, Orloff MS, Hezel AF. "Diabetes mellitus impacts risk of macrovascular invasion in patients undergoing transplantation for hepatocellular carcinoma." BMC Gastroenterology. 2013; : 139.

McCleary, N.J.; Odejide, O; Szymonifka, J; Ryan, D.P.; Hezel, AF; Meyerhardt, JA. "Safety and Effectiveness of Oxaliplatin-based Chemotherapy Regimens in Adults 75 Years and Older with Colorectal Cancer." Cinical Colorectal Cancer. 2013; 1: 62-9.

Goyal L, Supko JG, Berlin J, Blaszkowsky LS, Carpenter A, Heuman DM, Hilderbrand SL, Stuart KE, Cotler S, Senzer NN, Chan E, Berg CL, Clark JW, Hezel AF, Ryan DP, Zhu AX. "Phase 1 study of N 1,N 11-diethylnorspermine (DENSPM) in patients with advanced hepatocellular carcinoma." Phase 1 study of N 1,N 11-diethylnorspermine (DENSPM) in patients with advanced hepatocellular carcinoma. 2013; .

Hezel AF, Deshpande V, Zimmerman SM, Contino G, Alagesan B, O'Dell MR, Rivera LB, Harper J, Lonning S, Brekken RA, Bardeesy N. "TGF-? and ?v?6 integrin act in a common pathway to suppress pancreatic cancer progression." Cancer research.. 2012 Sep 15; 72(18):4840-5. Epub 2012 Jul 11.

O'Dell MR, Huang JL, Whitney-Miller CL, Deshpande V, Rothberg P, Grose V, Rossi RM, Zhu AX, Land H, Bardeesy N, Hezel AF. "Kras(G12D) and p53 mutation cause primary intrahepatic cholangiocarcinoma." Cancer research.. 2012 Mar 15; 72(6):1557-67. Epub 2012 Jan 20.

Hezel AF, Wadlow RC, Abrams TA, Blaszkowsky LS, Fuchs CS, Kulke MH, Kwak EL, Meyerhardt JA, Ryan DP, Szymonifka J, Wolpin BM, Zhu AX, Clark JW. "Panitumumab in Patients with KRAS Wild-Type Colorectal Cancer after Progression on Cetuximab." The Oncologist. 2012; : 14.

Darrell R. Borger, Kenneth K. Tanabe, Kenneth C. Fan, Hector U. Lopez, Valeria R. Fantin, Kimberly Straley, David P. Schenkein, Aram F. Hezel, Marek Ancukiewicz, Hannah M. Liebman, Eunice L. Kwak, Jeffrey W. Clark, David P. Ryan, Vikram Desphande, Dora Dias-Santagata, Leif W. Ellisen, Andrew X. Zhu, and A. John Iafrate. "Darre. Frequent Mutation of IDH1 and IDH2 in Cholangiocarcinoma Identified Through Broad-Based Tumor Genotyping." The Oncologist. 2012; .

Haoqiang Ying, Alec C. Kimmelman, Costas A. Lyssiotis, Sujun Hua, Gerald C. Chu, Eliot Fletcher-Sananikone, Jason W. Locasale, Jaekyoung Son, Hailei Zhang, Jonathan L. Coloff, Haiyan Yan, Wei Wang, Shujuan Chen, Andrea Viale, Hongwu Zheng, Ji-hye Paik, Carol Lim, Alexander R. Guimaraes, Eric S, Martin, Jeffery Chang, Aram F. Hezel, Samuel R. Perry, Jian Hu, Boyi Gan, Yonghong Xiao, John M. Asara, Ralph Weissleder, Y. Alan Wang, Lynda Chin, Lewis C. Cantley & Ronald A. DePinho. "Kras is required for pancreatic tumor maintenance through regulation of hexosamine biosynthesis and the non-oxidative pentose phosphate pathway." Cell. 2012; 3: 656-70.

A. Katz, S. Chawla, Z. Qu, R. Kashyap, A. Philip, M. Orloff, T. Smudzin, A F Hezel. "Stereotactic Body Radiation Therapy as Definitive Therapy or Bridge to Transplant for Hepatocellular Carcinoma: Clinical Outcome and Pathologic Correlation". A. Katz, S. Chawla, Z. Qu, R. Kashyap, A. Philip, M. Orloff, T. Smudzin, A F Hezel; Stereotactic Body Radiation Therapy as Definitive Therapy or Bridge to Transplant for Hepatocellular Carcinoma: Clinical Outcome and Pathologic Correlation; Int J Radiat Oncol Biol Phys. 2012 July 1, 83(3):895-900. 2012; : 895-900.

Connolly GC, Safadjou S, Chen R, Nduaguba A, Dunne R, Khorana A and Hezel AF. "Diabetes mellitus is associated with the presence of metastatic disease at disease presentation in hepatocellular carcinoma." Cancer Investigation. 2012; 10: 698-702.

Alexander BM, Fernandez-Del Castillo C, Ryan DP, Kachnic LA, Hezel AF, Niemierko A, Willett CG, Kozak KR, Blaszkowsky LS, Clark JW, Warshaw AL, Hong TS. "Intraductal papillary mucinous adenocarcinoma of the pancreas: clinical outcomes, prognostic factors, and the role of adjuvant therapy." Gastrointestinal cancer research : GCR.. 2011 Jul 0; 4(4):116-21.

Deshpande V, Nduaguba A, Zimmerman SM, Kehoe SM, MacConaill LE, Lauwers GY, Ferrone CY, Bardeesy N, Zhu AX, Hezel AF. "Mutational profiling reveals PIK3CA mutations in gallbladder carcinoma." BMC Cancer. 2011; : 60.

Ying H, Elpek KG, Vinjamoori A, Zimmerman SM., Chu GC, Yan H, Fletcher-Sananikone E, Zhang H, Liu Y, Wang W, Ren X, Zheng H, Kimmelman AC, Paik J, Lim C, Perry SR, Jiang S, Malinn B, Protopopov A, Colla S, Xiao Y, Hezel AF, Bardeesy N, Turley SJ, Wang YA, Chin L, Thayer SP, and DePinho RA. Pten. "Is a Major Tumor Suppressor in Pancreatic Ductal Adenocarcinoma and Regulates an NF-?B-Cytokine Network". Cancer Discov. 2011; 1: 158-169.

Faris JE, Arnott J, Zheng H, Ryan DP, Abrams TA, Blaszkowsky LS, Clark JW, Enzinger PC, Hezel AF, Ng K, Wolpin BM, Kwak EL. ". A phase 2 study of oral MKC-1, an inhibitor of importin-?, tubulin, and the mTOR pathway in patients with unresectable or metastatic pancreatic cancer." Invest New Drugs. 2011; .

Zhu AX, Sahani DV, Duda DG, di Tomaso E, Ancukiewicz M, Catalano OA, Sindhwani V, Blaszkowsky LS, Yoon SS, Lahdenranta J, Bhargava P, Meyerhardt J, Clark JW, Kwak EL, Hezel AF, Miksad R, Abrams TA, Enzinger PC, Fuchs CS, Ryan DP, Jain RK. "Efficacy, safety, and potential biomarkers of sunitinib monotherapy in advanced hepatocellular carcinoma: a phase II study." Journal of clinical oncology : official journal of the American Society of Clinical Oncology.. 2009 Jun 20; 27(18):3027-35. Epub 2009 May 26.

Plentz R, Park JS, Rhim AD, Abravanel D, Hezel AF, Sharma SV, Gurumurthy S, Deshpande V, Kenific C, Settleman J, Majumder PK, Stanger BZ, Bardeesy N. "Inhibition of gamma-secretase activity inhibits tumor progression in a mouse model of pancreatic ductal adenocarcinoma." Gastroenterology.. 2009 May 0; 136(5):1741-9.e6. Epub 2009 Jan 14.

Wolpin BM, Hezel AF, Abrams T, Blaszkowsky LS, Meyerhardt JA, Chan JA, Enzinger PC, Allen B, Clark JW, Ryan DP, Fuchs CS. "Oral mTOR inhibitor everolimus in patients with gemcitabine-refractory metastatic pancreatic cancer." Journal of clinical oncology : official journal of the American Society of Clinical Oncology.. 2009 Jan 10; 27(2):193-8. Epub 2008 Dec 01.

Kimmelman AC, Hezel AF, Aguirre AJ, Zheng H, Paik JH, Ying H, Chu GC, Zhang JX, Sahin E, Yeo G, Ponugoti A, Nabioullin R, Deroo S, Yang S, Wang X, McGrath JP, Protopopova M, Ivanova E, Zhang J, Feng B, Tsao MS, Redston M, Protopopov A, Xiao Y, Futreal PA, Hahn WC, Klimstra DS, Chin L, DePinho RA. "Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer." Proceedings of the National Academy of Sciences of the United States of America.. 2008 Dec 9; 105(49):19372-7. Epub 2008 Dec 02.

Hezel AF, Bardeesy N. "LKB1; linking cell structure and tumor suppression." Oncogene.. 2008 Nov 24; 27(55):6908-19.

Hezel AF, Bardeesy N. "Prognostic markers in pancreatic ductal adenocarcinomas." Cancer biology & therapy.. 2008 Sep 0; 7(9):1360-1. Epub 2008 Sep 06.

Hezel AF, Gurumurthy S, Granot Z, Swisa A, Chu GC, Bailey G, Dor Y, Bardeesy N, Depinho RA. "Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms." Molecular and cellular biology.. 2008 Apr 0; 28(7):2414-25. Epub 2008 Jan 28.

Perera SA, Maser RS, Xia H, McNamara K, Protopopov A, Chen L, Hezel AF, Kim CF, Bronson RT, Castrillon DH, Chin L, Bardeesy N, Depinho RA, Wong KK. "Telomere dysfunction promotes genome instability and metastatic potential in a K-ras p53 mouse model of lung cancer." Carcinogenesis.. 2008 Apr 0; 29(4):747-53. Epub 2008 Feb 17.

Hezel AF, Zhu AX. "Systemic therapy for biliary tract cancers." The oncologist.. 2008 Apr 0; 13(4):415-23.

Gurumurthy S, Hezel AF, Sahin E, Berger JH, Bosenberg MW, Bardeesy N. "LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesis." Cancer research.. 2008 Jan 1; 68(1):55-63.

Chu GC, Kimmelman AC, Hezel AF, DePinho RA. "Stromal biology of pancreatic cancer." Journal of cellular biochemistry.. 2007 Jul 1; 101(4):887-907.

Hezel AF, Ryan DP. "Emerging therapies for colorectal cancer." Expert opinion on investigational drugs.. 2007 Jun 0; 16(6):867-76.

Geyer N, Bartges JW, Kirk CA, Cox S, Hezel A, Moyers T, Hayes J. "Influence of prednisolone on urinary calcium oxalate and struvite relative supersaturation in healthy young adult female domestic shorthaired cats." Veterinary therapeutics : research in applied veterinary medicine. 2007 8(4):239-46.

Bardeesy N, Cheng KH, Berger JH, Chu GC, Pahler J, Olson P, Hezel AF, Horner J, Lauwers GY, Hanahan D, DePinho RA. "Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer." Genes & development.. 2006 Nov 15; 20(22):3130-46.

Hezel AF, Kimmelman AC, Stanger BZ, Bardeesy N, Depinho RA. "Genetics and biology of pancreatic ductal adenocarcinoma." Genes & development.. 2006 May 15; 20(10):1218-49.

Bardeesy N, Aguirre AJ, Chu GC, Cheng KH, Lopez LV, Hezel AF, Feng B, Brennan C, Weissleder R, Mahmood U, Hanahan D, Redston MS, Chin L, Depinho RA. "Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse." Proceedings of the National Academy of Sciences of the United States of America.. 2006 Apr 11; 103(15):5947-52. Epub 2006 Apr 03.

Ji H, Houghton AM, Mariani TJ, Perera S, Kim CB, Padera R, Tonon G, McNamara K, Marconcini LA, Hezel A, El-Bardeesy N, Bronson RT, Sugarbaker D, Maser RS, Shapiro SD, Wong KK. "K-ras activation generates an inflammatory response in lung tumors." Oncogene.. 2006 Mar 30; 25(14):2105-12.

Hezel AF, Bardeesy N, Maser RS. "Telomere induced senescence: end game signaling." Current molecular medicine. 2005 Mar 0; 5(2):145-52.

Bardeesy N, Sinha M, Hezel AF, Signoretti S, Hathaway NA, Sharpless NE, Loda M, Carrasco DR, DePinho RA. "Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation." Nature.. 2002 Sep 12; 419(6903):162-7.

Bardeesy N, Bastian BC, Hezel A, Pinkel D, DePinho RA, Chin L. "Dual inactivation of RB and p53 pathways in RAS-induced melanomas." Molecular and cellular biology.. 2001 Mar 0; 21(6):2144-53.

Giese H, Dollé ME, Hezel A, van Steeg H, Vijg J. "Accelerated accumulation of somatic mutations in mice deficient in the nucleotide excision repair gene XPA." Oncogene.. 1999 Feb 4; 18(5):1257-60.

Conan Kinsey, Vijaya Balakrishnan, Michael R. O'Dell, Jing Li Huang, Laurel Newman, Christa L. Whitney-Miller, Aram F. Hezel, and Hartmut Land (Co-corresponding). "Plac8 links oncogenic mutations to regulation of autophagy and is critical to pancreatic cancer progression." Cell Reports, in press. .