Craig Morrell, D.V.M., Ph.D.

Craig Morrell, D.V.M., Ph.D.

Contact Information

Aab Cardiovascular Research Institute
601 Elmwood Avenue
Rochester, NY 14642

Fax: (585) 276-1530
Office: (585) 276-7693
Lab: (585) 276-7722
Administrative: (585) 276-7698

Journal Articles

Showing all 41 journal articles available.

2016 May
Modjeski KL, Levy SC, Ture SK, Field DJ, Shi G, Ko K, Zhu Q, Morrell CN. "Glutamate Receptor Interacting Protein 1 Regulates CD4(+) CTLA-4 Expression and Transplant Rejection." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2016 May; 16(5):1383-93. Epub 2016 Feb 25.
2016 Mar
Lannan KL, Refaai MA, Ture SK, Morrell CN, Blumberg N, Phipps RP, Spinelli SL. "Resveratrol preserves the function of human platelets stored for transfusion." British journal of haematology. 2016 Mar; 172(5):794-806. Epub 2015 Dec 18.
2015 Sep 15
Batchu SN, Xia J, Ko KA, Doyley MM, Abe JI, Morrell CN, Korshunov VA. "Axl modulates immune activation of smooth muscle cells in vein graft remodeling." American journal of physiology. Heart and circulatory physiology. 2015 Sep 15; 309(6):H1048-58. Epub 2015 Aug 14.
2015 Jul 7
Cameron SJ, Ture SK, Mickelsen D, Chakrabarti E, Modjeski KL, McNitt S, Seaberry M, Field DJ, Le NT, Abe JI, Morrell CN. "Platelet Extracellular Regulated Protein Kinase 5 Is a Redox Switch and Triggers Maladaptive Platelet Responses and Myocardial Infarct Expansion." Circulation. 2015 Jul 7; 132(1):47-58. Epub 2015 May 01.
Cameron SJ, Morrell CN, Bao C, Swaim AF, Rodriguez A, Lowenstein CJ. "A Novel Anti-Inflammatory Effect for High Density Lipoprotein." PloS one. 2015 10(12):e0144372. Epub 0/17/2015.
2014 Sep
Morrell CN. "Understanding platelets in malaria infection." Current opinion in hematology. 2014 Sep; 21(5):445-9.
2014 May 5
Wang L, Soe NN, Sowden M, Xu Y, Modjeski K, Baskaran P, Kim Y, Smolock EM, Morrell C, Berk BC. "Cyclophilin A is an important mediator of platelet function by regulating integrin ?IIb?3 bidirectional signalling." Thrombosis and haemostasis. 2014 May 5; 111(5):873-82. Epub 2014 Jan 16.
2014 May 1
Morrell CN, Aggrey AA, Chapman LM, Modjeski KL. "Emerging roles for platelets as immune and inflammatory cells." Blood. 2014 May 1; 123(18):2759-67. Epub 2014 Feb 28.
2014 Apr 15
Metcalf Pate KA, Lyons CE, Dorsey JL, Queen SE, Adams RJ, Morrell CN, Mankowski JL. "TGF?-Mediated Downregulation of Thrombopoietin Is Associated With Platelet Decline in Asymptomatic SIV Infection." Journal of acquired immune deficiency syndromes : JAIDS. 2014 Apr 15; 65(5):510-6.
2014 Jan
Modjeski KL, Morrell CN. "Small cells, big effects: the role of platelets in transplant vasculopathy." Journal of thrombosis and thrombolysis. 2014 Jan; 37(1):17-23.
2013 May 23
Shi G, Field DJ, Long X, Mickelsen D, Ko KA, Ture S, Korshunov VA, Miano JM, Morrell CN. "Platelet factor 4 mediates vascular smooth muscle cell injury responses." Blood. 2013 May 23; 121(21):4417-27. Epub 2013 Apr 08.
2013 May 1
Aggrey AA, Srivastava K, Ture S, Field DJ, Morrell CN. "Platelet induction of the acute-phase response is protective in murine experimental cerebral malaria." The Journal of immunology : official journal of the American Association of Immunologists. 2013 May 1; 190(9):4685-91. Epub 2013 Mar 27.
2012 Jul 15
Chapman LM, Aggrey AA, Field DJ, Srivastava K, Ture S, Yui K, Topham DJ, Baldwin WM, Morrell CN. "Platelets present antigen in the context of MHC class I." The Journal of immunology : official journal of the American Association of Immunologists. 2012 Jul 15; 189(2):916-23. Epub 2012 Jun 15.
2011 Sep
Morrell CN, Maggirwar SB. "Recently recognized platelet agonists." Current opinion in hematology. 2011 Sep; 18(5):309-14.
2011 May
Shi G, Morrell CN. "Platelets as initiators and mediators of inflammation at the vessel wall." Thrombosis research. 2011 May; 127(5):387-90. Epub 2010 Nov 20.
2011 Apr
Morrell CN, Srivastava K, Swaim A, Lee MT, Chen J, Nagineni C, Hooks JJ, Detrick B. "Beta interferon suppresses the development of experimental cerebral malaria." Infection and immunity. 2011 Apr; 79(4):1750-8. Epub 2011 Jan 18.
2011 Jan 1
Davidson DC, Hirschman MP, Spinelli SL, Morrell CN, Schifitto G, Phipps RP, Maggirwar SB. "Antiplatelet activity of valproic acid contributes to decreased soluble CD40 ligand production in HIV type 1-infected individuals." The Journal of immunology : official journal of the American Association of Immunologists. 2011 Jan 1; 186(1):584-91. Epub 2010 Nov 29.
Morrell CN. "Immunomodulatory mediators in platelet transfusion reactions." Hematology. 2011 2011:470-4.
2010 Oct
Ombrello C, Block RC, Morrell CN. "Our expanding view of platelet functions and its clinical implications." Journal of cardiovascular translational research. 2010 Oct; 3(5):538-46. Epub 2010 Jul 27.
Srivastava K, Field DJ, Aggrey A, Yamakuchi M, Morrell CN. "Platelet factor 4 regulation of monocyte KLF4 in experimental cerebral malaria." PloS one. 2010 5(5):e10413. Epub 2010 May 03.
2009 Nov 24
Steele BM, Harper MT, Macaulay IC, Morrell CN, Perez-Tamayo A, Foy M, Habas R, Poole AW, Fitzgerald DJ, Maguire PB. "Canonical Wnt signaling negatively regulates platelet function." Proceedings of the National Academy of Sciences of the United States of America. 2009 Nov 24; 106(47):19836-41. Epub 2009 Nov 09.
2009 Sep 11
Sun H, Swaim A, Herrera JE, Becker D, Becker L, Srivastava K, Thompson LE, Shero MR, Perez-Tamayo A, Suktitpat B, Mathias R, Contractor A, Faraday N, Morrell CN. "Platelet kainate receptor signaling promotes thrombosis by stimulating cyclooxygenase activation." Circulation research. 2009 Sep 11; 105(6):595-603. Epub 2009 Aug 13.
2009 Mar 10
Jeong Y, Chaupin DF, Matsushita K, Yamakuchi M, Cameron SJ, Morrell CN, Lowenstein CJ. "Aldosterone activates endothelial exocytosis." Proceedings of the National Academy of Sciences of the United States of America. 2009 Mar 10; 106(10):3782-7. Epub 2009 Feb 17.
2008 Aug 14
Srivastava K, Cockburn IA, Swaim A, Thompson LE, Tripathi A, Fletcher CA, Shirk EM, Sun H, Kowalska MA, Fox-Talbot K, Sullivan D, Zavala F, Morrell CN. "Platelet factor 4 mediates inflammation in experimental cerebral malaria." Cell host & microbe. 2008 Aug 14; 4(2):179-87.
2008 Mar 17
Morrell CN, Sun H, Ikeda M, Beique JC, Swaim AM, Mason E, Martin TV, Thompson LE, Gozen O, Ampagoomian D, Sprengel R, Rothstein J, Faraday N, Huganir R, Lowenstein CJ. "Glutamate mediates platelet activation through the AMPA receptor." The Journal of experimental medicine. 2008 Mar 17; 205(3):575-84. Epub 2008 Feb 18.
2008 Feb
Shi C, Parker AR, Hua L, Morrell CN, Lee SC, Bandaru V, Dumler JS, Wu TC, Eshleman JR. "Anti-gene padlocks eliminate Escherichia coli based on their genotype." The Journal of antimicrobial chemotherapy. 2008 Feb; 61(2):262-72. Epub 2007 Dec 22.
Morrell, CN.; Mason, EA.; Martin, TV.; Swaim, AM.; Ballard, M.; Murata, K.; Baldwin, WM. "Alloantibodies to MHC Induce Platelet-Endothelial Cell Interactions". Circulation Research. 2008; 102(7): 777-785.
Yamakuchi M, Ferlito M, Morrell CN, Matsushita K, Fletcher CA, Cao W, Lowenstein CJ. "Exocytosis of endothelial cells is regulated by N-ethylmaleimide-sensitive factor." Methods in molecular biology. 2008 440:203-15.
2005 Jul 4
Matsushita K, Morrell CN, Mason RJ, Yamakuchi M, Khanday FA, Irani K, Lowenstein CJ. "Hydrogen peroxide regulation of endothelial exocytosis by inhibition of N-ethylmaleimide sensitive factor." The Journal of cell biology. 2005 Jul 4; 170(1):73-9.
2005 Jul
Morrell CN, Matsushita K, Lowenstein CJ. "A novel inhibitor of N-ethylmaleimide-sensitive factor decreases leukocyte trafficking and peritonitis." The Journal of pharmacology and experimental therapeutics. 2005 Jul; 314(1):155-61. Epub 2005 Mar 18.
2005 Jun 10
Yamakuchi M, Greer JJ, Cameron SJ, Matsushita K, Morrell CN, Talbot-Fox K, Baldwin WM, Lefer DJ, Lowenstein CJ. "HMG-CoA reductase inhibitors inhibit endothelial exocytosis and decrease myocardial infarct size." Circulation research. 2005 Jun 10; 96(11):1185-92. Epub 2005 May 19.
2005 Apr
Matsushita K, Morrell CN, Lowenstein CJ. "A novel class of fusion polypeptides inhibits exocytosis." Molecular pharmacology. 2005 Apr; 67(4):1137-44. Epub 0/17/2004.
2005 Mar 8
Morrell CN, Matsushita K, Chiles K, Scharpf RB, Yamakuchi M, Mason RJ, Bergmeier W, Mankowski JL, Baldwin WM, Faraday N, Lowenstein CJ. "Regulation of platelet granule exocytosis by S-nitrosylation." Proceedings of the National Academy of Sciences of the United States of America. 2005 Mar 8; 102(10):3782-7. Epub 2005 Feb 28.
2005 Jan 1
Matsushita K, Yamakuchi M, Morrell CN, Ozaki M, O'Rourke B, Irani K, Lowenstein CJ. "Vascular endothelial growth factor regulation of Weibel-Palade-body exocytosis." Blood. 2005 Jan 1; 105(1):207-14. Epub 2004 Sep 02.
2004 Aug 6
Bhatia R, Matsushita K, Yamakuchi M, Morrell CN, Cao W, Lowenstein CJ. "Ceramide triggers Weibel-Palade body exocytosis." Circulation research. 2004 Aug 6; 95(3):319-24. Epub 2004 Jun 24.
2004 Aug 3
Matsushita K, Morrell CN, Lowenstein CJ. "Sphingosine 1-phosphate activates Weibel-Palade body exocytosis." Proceedings of the National Academy of Sciences of the United States of America. 2004 Aug 3; 101(31):11483-7. Epub 2004 Jul 23.
2003 Oct 17
Matsushita K, Morrell CN, Cambien B, Yang SX, Yamakuchi M, Bao C, Hara MR, Quick RA, Cao W, O'Rourke B, Lowenstein JM, Pevsner J, Wagner DD, Lowenstein CJ. "Nitric oxide regulates exocytosis by S-nitrosylation of N-ethylmaleimide-sensitive factor." Cell. 2003 Oct 17; 115(2):139-50.
2003 Feb
Chen WY, Zeng X, Carter MG, Morrell CN, Chiu Yen RW, Esteller M, Watkins DN, Herman JG, Mankowski JL, Baylin SB. "Heterozygous disruption of Hic1 predisposes mice to a gender-dependent spectrum of malignant tumors." Nature genetics. 2003 Feb; 33(2):197-202. Epub 2003 Jan 21.
2002 Nov
Morrell CN, Volk MV, Mankowski JL. "A carcinoid tumor in the gallbladder of a dog." Veterinary pathology. 2002 Nov; 39(6):756-8.
1997 Mar 27
Mathiowitz E, Jacob JS, Jong YS, Carino GP, Chickering DE, Chaturvedi P, Santos CA, Vijayaraghavan K, Montgomery S, Bassett M, Morrell C. "Biologically erodable microspheres as potential oral drug delivery systems." Nature. 1997 Mar 27; 386(6623):410-4.
Chickering, D.E.; Jacob, J.S.; Desai, M.; Harrison, W.P.; Morrell, C.N.; Chatuverdi, P.; Mathiowitz, E. "Bioadhesive Microspheres: III. An In Vivo Transit and Bioavailability Study of Drug-Loaded Alginate and Poly(Fumaric-co-Sebacic Anhydride) Microspheres". Journal of Controlled Release. 1997; 48: 35-46.