Wakenda Tyler, M.D., M.P.H.

Wakenda Tyler, M.D., M.P.H.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 665
Rochester, NY 14642

Administrative: (585) 276-4760
Fax: (585) 756-4727

Research Bio

Dr. Tyler's research interests overlap with her clinical practice and center around the treatment of patients with bone and soft tissue tumors and conditions that lead to osteolysis (bone destruction as a result of implant wear and loosening or presence of tumor). Her areas of on-going research at this time include:

1) Treatment of aggressive benign conditions, such as pigmented villonodular synovitis and giant cell tumor of bone. More specifically, the molecular and cellular signaling pathways of cells in these conditions and the genetic alterations that lead to such conditions.

2) Medical and surgical treatment of soft tissue sarcomas.

3) Inhibiting osteolysis in both benign and malignant bone conditions.

4) Allograft implantation for large bone defects.

5) Treatment of metastatic disease to bone from other organs systems.

Awards & Honors (National)

American Orthopaedic Association Future Leaders in Orthopaedics recipient | American Orthopaedic Association 2006

Awards & Honors (Local)

Joseph M. Lane, MD Resident Research Grant recipient 2006
Phi Beta Kappa Honors Society Inductee | Johns Hopkins School of Hygiene and Public Health 2002 - 2002
Alpha Omega Alpha National Medical Honors Society Inductee 2002
Monumental City Medical Society Scholarship Recipient 2001 - 2002
Johns Hopkins School of Hygiene and Public Health Watt-Hansel Scholarship recipient | Johns Hopkins School of Hygiene and Public Health 2000 - 2001
The Class of 1895 Award | Millersville University 1997
The Fontes Health Professions Award in Pre-Med 1997
The Cecil Upton Organic Chemistry Award 1997
Summa Cum Laude, Department Honors and University Honors | Millersville University 1997
Phi Kappa Phi Honors Society inductee | Millersville University 1996 - 1997
Scholar Athlete Award receipient in cross country, track and field | Millersville University 1993 - 1994

Recent Journal Articles

Showing the 5 most recent journal articles. 15 available »

2015 Sep
Xie C, Li Y, Li Q, Chen Y, Yao J, Yin G, Bi Q, O'Keefe RJ, Schwarz EM, Tyler W. "Increased Insulin mRNA Binding Protein-3 Expression Correlates with Vascular Enhancement of Renal Cell Carcinoma by Intravenous Contrast-CT and is Associated with Bone Metastasis." Journal of bone oncology. 2015 Sep; 4(3):69-76. Epub 2015 Sep 12.
2014 Nov
Thorsness R, English C, Gross J, Tyler W, Voloshin I, Gorczyca J. "Proximal humerus fractures with associated axillary artery injury." Journal of orthopaedic trauma. 2014 Nov; 28(11):659-63.
2014 Nov
Subik MK, Herr MM, Hutchison RE, Kelly J, Tyler WK, Merzianu M, Burack WR. "A highly curable lymphoma occurs preferentially in the proximal tibia of young patients." Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 2014 Nov; 27(11):1430-7. Epub 2014 Apr 18.
2012 Feb
Xie C, Schwarz EM, Sampson ER, Dhillon RS, Li D, O'Keefe RJ, Tyler W. "Unique angiogenic and vasculogenic properties of renal cell carcinoma in a xenograft model of bone metastasis are associated with high levels of vegf-a and decreased ang-1 expression." Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2012 Feb; 30(2):325-33. Epub 2011 Aug 01.
2011 Jan
Bukata SV, Digiovanni BF, Friedman SM, Hoyen H, Kates A, Kates SL, Mears SC, Mendelson DA, Serna FH, Sieber FE, Tyler WK. "A guide to improving the care of patients with fragility fractures." Geriatric orthopaedic surgery & rehabilitation. 2011 Jan; 2(1):5-37.

Current Appointments

Associate Professor - Department of Orthopaedics (SMD) - Primary


Orthopaedic Surgery - American Board of Orthopedic Surgery


MD | Medicine | Johns Hopkins University School of Medicine2002
MPH | Public Health | Johns Hopkins University2001
BA | Psychology | Millersville State College1997

Post-Doctoral Training & Residency

Fellowship at Memorial Sloan-Kettering Cancer Center08/01/2007 - 07/31/2009
Residency in Orthopaedic Surgery at Hospital for Special Surgery06/01/2003 - 06/30/2007
Internship in Orthopaedic Surgery at Hospital for Special Surgery06/01/2002 - 06/30/2003