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Wakenda Tyler, M.D., M.P.H.

Cancer, Orthopaedics & Rehabilitation

Clinical Interests

Arthritis & Lower Extremity Joint Replacement - Surgical Bone Sarcoma, Bone Cancer Bone Tumor, Orthopaedic Tumor Hip Replacement Surgery Knee Replacement Orthopaedic Oncology

Contact Information

Phone Numbers

Administrative: (585) 276-4760

Appointment: (585) 275-5321

Fax: (585) 756-4727

URMFGA member of the University of Rochester Medical Faculty Group

groupAn Accountable Health Partner

assignmentAccepting New Patients


My goal is to provide compassionate surgical care that achieves cure of cancer whenever possible. When cure is not possible, I strive to achieve pain control and improve function as best as possible through surgical interventions. Since early in my medical school training, I knew I wanted to be a surgeon who treats patients with cancer. This is likely because I lost several friends and family members to this disease. My love of the musculoskeletal system – and desire to improve the function of the people I care for – drove me in the direction of orthopaedic surgical oncology. My areas of special interest include musculoskeletal oncology, sarcoma and metastatic bone cancer. Every patient who sees me is treated with equal respect and compassion. I am also honest and let my patients know in all sincerity if their problem is one I can help with or not. Conditions I Treat: - Primary soft tissue and bone cancers of the extremities, pelvis and shoulder girdle - Bone and soft tissue sarcomas - Metastatic bone cancer

Professional Background

Dr. Tyler earned her medical degree from The John Hopkins University School of Medicine and completed her residency in orthopaedic surgery at the Hospital for Special Surgery. She then completed a fellowship in musculoskeletal oncology at the Memorial Sloan Kettering Cancer Center. Dr. Tyler has written medical journal articles on several bone diseases, the effectiveness of medication in penetrating to the site of bone grafts, and the strength of the bone and prosthesis union. Dr. Tyler is an Assistant Professor in URMC's Orthopaedic Oncology and Metabolic Bone Disease and Adult Reconstruction.


Dr. Tyler's research interests overlap with her clinical practice and center around the treatment of patients with bone and soft tissue tumors and conditions that lead to osteolysis (bone destruction as a result of implant wear and loosening or presence of tumor). Her areas of on-going research at this time include: 1) Treatment of aggressive benign conditions, such as pigmented villonodular synovitis and giant cell tumor of bone. More specifically, the molecular and cellular signaling pathways of cells in these conditions and the genetic alterations that lead to such conditions. 2) Medical and surgical treatment of soft tissue sarcomas. 3) Inhibiting osteolysis in both benign and malignant bone conditions. 4) Allograft implantation for large bone defects. 5) Treatment of metastatic disease to bone from other organs systems.


Faculty Appointments


  • Orthopaedic Surgery - American Board of Orthopedic Surgery


MPH | Johns Hopkins University
Public Health

BA | Millersville State College

MD | Johns Hopkins University School of Medicine

Post-doctoral Training & Residency

06/01/2002 - 06/30/2003
Internship in Orthopaedic Surgery at Hospital for Special Surgery

06/01/2003 - 06/30/2007
Residency in Orthopaedic Surgery at Hospital for Special Surgery

08/01/2007 - 07/31/2009
Fellowship in at Memorial Sloan-Kettering Cancer Center

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American Orthopaedic Association Future Leaders in Orthopaedics recipient
Sponsor: American Orthopaedic Association

Joseph M. Lane, MD Resident Research Grant recipient

2002 - 2002
Phi Beta Kappa Honors Society Inductee
Sponsor: Johns Hopkins School of Hygiene and Public Health

Alpha Omega Alpha National Medical Honors Society Inductee

2001 - 2002
Monumental City Medical Society Scholarship Recipient

2000 - 2001
Johns Hopkins School of Hygiene and Public Health Watt-Hansel Scholarship recipient
Sponsor: Johns Hopkins School of Hygiene and Public Health

The Class of 1895 Award
Sponsor: Millersville University

The Fontes Health Professions Award in Pre-Med

The Cecil Upton Organic Chemistry Award

Summa Cum Laude, Department Honors and University Honors
Sponsor: Millersville University

1996 - 1997
Phi Kappa Phi Honors Society inductee
Sponsor: Millersville University

1993 - 1994
Scholar Athlete Award receipient in cross country, track and field
Sponsor: Millersville University

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Journal Articles

Lander ST, Coppola E, Tyler W, Elfar JC. "A Peculiar Primary Paraganglioma of the Distal Thumb." The Journal of hand surgery.. 2016 May 0; 41(5):e91-4. Epub 2016 Mar 09.

Xie C, Li Y, Li Q, Chen Y, Yao J, Yin G, Bi Q, O'Keefe RJ, Schwarz EM, Tyler W. "Increased Insulin mRNA Binding Protein-3 Expression Correlates with Vascular Enhancement of Renal Cell Carcinoma by Intravenous Contrast-CT and is Associated with Bone Metastasis." Journal of bone oncology. 2015 Sep 0; 4(3):69-76. Epub 2015 Sep 12.

Tyler WK, Mir HR, Zlotolow DA, Kroonen LT. "The AOA-JOA 2014 exchange traveling fellowship: Banzai and beyond." The Journal of bone and joint surgery. American volume.. 2015 Feb 18; 97(4):e22.

Books & Chapters

Chapter Title: The role of orthopedic surgery in the palliative care of patients with cancer
Book Title: Oxford's Text Book of Paliative Care
Author List: Tyler, W; Healey, JH
Published By: Oxford University Press2009