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Isaac Kirubakaran Sundar, Ph.D.

Publications

Showing all 51 journal articles & 0 books available

Journal Articles

9/2018
Sundar IK, Rashid K, Gerloff J, Rangel-Moreno J, Li D, Rahman I. "Genetic ablation of histone deacetylase 2 leads to lung cellular senescence and lymphoid follicle formation in COPD/emphysema." FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2018 Sep 0; 32(9):4955-4971. Epub 2018 Apr 09.

8/2018
Sundar IK, Rashid K, Gerloff J, Li D, Rahman I. "Genetic Ablation of p16 Does Not Protect against Cellular Senescence in Mouse Models of Chronic Obstructive Pulmonary Disease/Emphysema." American journal of respiratory cell and molecular biology.. 2018 Aug 0; 59(2):189-199.

6/13/2018
Rashid K, Sundar IK, Gerloff J, Li D, Rahman I. "Lung cellular senescence is independent of aging in a mouse model of COPD/emphysema." Scientific reports.. 2018 Jun 13; 8(1):9023. Epub 2018 Jun 13.

5/1/2018
Sundar IK, Sellix MT, Rahman I. "Redox regulation of circadian molecular clock in chronic airway diseases." Free radical biology & medicine.. 2018 May 1; 119:121-128. Epub 2017 Oct 31.

2/2018
Khan NA, Sundar IK, Rahman I. "Strain- and sex-dependent pulmonary toxicity of waterpipe smoke in mouse." Physiological reports.. 2018 Feb 0; 6(3)

11/2017
Javed F, Kellesarian SV, Sundar IK, Romanos GE, Rahman I. "Recent updates on electronic cigarette aerosol and inhaled nicotine effects on periodontal and pulmonary tissues." Oral diseases.. 2017 Nov 0; 23(8):1052-1057. Epub 2017 Mar 30.

9/2017
Rahman I, De Cunto G, Sundar IK, Lungarella G. "Vulnerability and Genetic Susceptibility to Cigarette Smoke-Induced Emphysema in Mice." American journal of respiratory cell and molecular biology.. 2017 Sep 0; 57(3):270-271.

5/2017
Lee H, Park JR, Kim WJ, Sundar IK, Rahman I, Park SM, Yang SR. "Blockade of RAGE ameliorates elastase-induced emphysema development and progression RAGE-DAMP signaling." FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2017 May 0; 31(5):2076-2089. Epub 2017 Feb 01.

3/3/2017
Lei W, Lerner C, Sundar IK, Rahman I. "Myofibroblast differentiation and its functional properties are inhibited by nicotine and e-cigarette via mitochondrial OXPHOS complex III." Scientific reports.. 2017 Mar 3; 7:43213. Epub 2017 Mar 03.

3/1/2017
Gerloff J, Sundar IK, Freter R, Sekera ER, Friedman AE, Robinson R, Pagano T, Rahman I. "Inflammatory Response and Barrier Dysfunction by Different e-Cigarette Flavoring Chemicals Identified by Gas Chromatography-Mass Spectrometry in e-Liquids and e-Vapors on Human Lung Epithelial Cells and Fibroblasts." Applied in vitro toxicology.. 2017 Mar 1; 3(1):28-40.

2017
Muthumalage T, Prinz M, Ansah KO, Gerloff J, Sundar IK, Rahman I. "Inflammatory and Oxidative Responses Induced by Exposure to Commonly Used e-Cigarette Flavoring Chemicals and Flavored e-Liquids without Nicotine." Frontiers in physiology.. 2017 8:1130. Epub 2018 Jan 11.

12/1/2016
Sundar IK, Rahman I. "Gene expression profiling of epigenetic chromatin modification enzymes and histone marks by cigarette smoke: implications for COPD and lung cancer." American journal of physiology. Lung cellular and molecular physiology.. 2016 Dec 1; 311(6):L1245-L1258. Epub 2016 Oct 28.

11/22/2016
Sundar IK, Javed F, Romanos GE, Rahman I. "E-cigarettes and flavorings induce inflammatory and pro-senescence responses in oral epithelial cells and periodontal fibroblasts." Oncotarget.. 2016 Nov 22; 7(47):77196-77204.

9/2/2016
Lerner CA, Rutagarama P, Ahmad T, Sundar IK, Elder A, Rahman I. "Electronic cigarette aerosols and copper nanoparticles induce mitochondrial stress and promote DNA fragmentation in lung fibroblasts." Biochemical and biophysical research communications.. 2016 Sep 2; 477(4):620-625. Epub 2016 Jun 23.

2016
Lerner CA, Lei W, Sundar IK, Rahman I. "Genetic Ablation of CXCR2 Protects against Cigarette Smoke-Induced Lung Inflammation and Injury." Frontiers in pharmacology.. 2016 7:391. Epub 2016 Oct 25.

12/2015
Yao H, Sundar IK, Huang Y, Gerloff J, Sellix MT, Sime PJ, Rahman I. "Disruption of Sirtuin 1-Mediated Control of Circadian Molecular Clock and Inflammation in Chronic Obstructive Pulmonary Disease." American journal of respiratory cell and molecular biology.. 2015 Dec 0; 53(6):782-92.

11/15/2015
Sundar IK, Yao H, Sellix MT, Rahman I. "Circadian molecular clock in lung pathophysiology." American journal of physiology. Lung cellular and molecular physiology.. 2015 Nov 15; 309(10):L1056-75. Epub 2015 Sep 11.

9/2015
Sundar IK, Yao H, Sellix MT, Rahman I. "Circadian clock-coupled lung cellular and molecular functions in chronic airway diseases." American journal of respiratory cell and molecular biology.. 2015 Sep 0; 53(3):285-90.

7/2015
Ahmad T, Sundar IK, Lerner CA, Gerloff J, Tormos AM, Yao H, Rahman I. "Impaired mitophagy leads to cigarette smoke stress-induced cellular senescence: implications for chronic obstructive pulmonary disease." FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2015 Jul 0; 29(7):2912-29. Epub 2015 Mar 19.

4/29/2015
Sundar IK, Ahmad T, Yao H, Hwang JW, Gerloff J, Lawrence BP, Sellix MT, Rahman I. "Influenza A virus-dependent remodeling of pulmonary clock function in a mouse model of COPD." Scientific reports.. 2015 Apr 29; 4:9927. Epub 2015 Apr 29.

3/2015
Lerner CA, Sundar IK, Watson RM, Elder A, Jones R, Done D, Kurtzman R, Ossip DJ, Robinson R, McIntosh S, Rahman I. "Environmental health hazards of e-cigarettes and their components: Oxidants and copper in e-cigarette aerosols." Environmental pollution.. 2015 Mar 0; 198:100-7. Epub 2015 Jan 09.

2015
Lerner CA, Sundar IK, Yao H, Gerloff J, Ossip DJ, McIntosh S, Robinson R, Rahman I. "Vapors produced by electronic cigarettes and e-juices with flavorings induce toxicity, oxidative stress, and inflammatory response in lung epithelial cells and in mouse lung." PloS one.. 2015 10(2):e0116732. Epub 2015 Feb 06.

5/1/2014
Yao H, Sundar IK, Ahmad T, Lerner C, Gerloff J, Friedman AE, Phipps RP, Sime PJ, McBurney MW, Guarente LP, Rahman I. "SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism." American journal of physiology. Lung cellular and molecular physiology.. 2014 May 1; 306(9):L816-28. Epub 2014 Mar 14.

2/7/2014
Rahman I, Sundar IK, Nevid MZ, Friedman AE. "Cigarette smoke induces distinct histone modifications in lung cells: implications for the pathogenesis of COPD and lung cancer." Journal of proteome research.. 2014 Feb 7; 13(2):982-96. Epub 2013 Dec 13.

1/2014
Hwang JW, Sundar IK, Yao H, Sellix MT, Rahman I. "Circadian clock function is disrupted by environmental tobacco/cigarette smoke, leading to lung inflammation and injury via a SIRT1-BMAL1 pathway." FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2014 Jan 0; 28(1):176-94. Epub 2013 Sep 11.

2014
Sundar IK, Yao H, Huang Y, Lyda E, Sime PJ, Sellix MT, Rahman I. "Serotonin and corticosterone rhythms in mice exposed to cigarette smoke and in patients with COPD: implication for COPD-associated neuropathogenesis." PloS one.. 2014 9(2):e87999. Epub 2014 Feb 10.

11/1/2013
Yao H, Hwang JW, Sundar IK, Friedman AE, McBurney MW, Guarente LP, Gu W, Kinnula VL, Rahman I. "SIRT1 redresses the imbalance of tissue inhibitor of matrix metalloproteinase-1 and matrix metalloproteinase-9 in the development of mouse emphysema and human COPD." American journal of physiology. Lung cellular and molecular physiology.. 2013 Nov 1; 305(9):L615-24. Epub 2013 Sep 13.

8/2013
Hwang JW, Yao H, Caito S, Sundar IK, Rahman I. "Redox regulation of SIRT1 in inflammation and cellular senescence." Free radical biology & medicine.. 2013 Aug 0; 61:95-110. Epub 2013 Mar 27.

5/20/2013
Sundar IK, Yao H, Rahman I. "Oxidative stress and chromatin remodeling in chronic obstructive pulmonary disease and smoking-related diseases." Antioxidants & redox signaling.. 2013 May 20; 18(15):1956-71. Epub 2012 Nov 06.

2013
Yao H, Sundar IK, Gorbunova V, Rahman I. "P21-PARP-1 pathway is involved in cigarette smoke-induced lung DNA damage and cellular senescence." PloS one.. 2013 8(11):e80007. Epub 2013 Nov 11.

11/15/2012
Agarwal AR, Zhao L, Sancheti H, Sundar IK, Rahman I, Cadenas E. "Short-term cigarette smoke exposure induces reversible changes in energy metabolism and cellular redox status independent of inflammatory responses in mouse lungs." American journal of physiology. Lung cellular and molecular physiology.. 2012 Nov 15; 303(10):L889-98. Epub 2012 Oct 12.

6/2012
Yao H, Chung S, Hwang JW, Rajendrasozhan S, Sundar IK, Dean DA, McBurney MW, Guarente L, Gu W, Rönty M, Kinnula VL, Rahman I. "SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice." The Journal of clinical investigation.. 2012 Jun 0; 122(6):2032-45. Epub 2012 May 01.

2012
Sundar IK, Chung S, Hwang JW, Lapek JD, Bulger M, Friedman AE, Yao H, Davie JR, Rahman I. "Mitogen- and stress-activated kinase 1 (MSK1) regulates cigarette smoke-induced histone modifications on NF-?B-dependent genes." PloS one.. 2012 7(2):e31378. Epub 2012 Feb 01.

7/15/2011
Hwang JW, Rajendrasozhan S, Yao H, Chung S, Sundar IK, Huyck HL, Pryhuber GS, Kinnula VL, Rahman I. "FOXO3 deficiency leads to increased susceptibility to cigarette smoke-induced inflammation, airspace enlargement, and chronic obstructive pulmonary disease." The Journal of immunology : official journal of the American Association of Immunologists.. 2011 Jul 15; 187(2):987-98. Epub 2011 Jun 20.

7/2011
Sundar IK, Mullapudi N, Yao H, Spivack SD, Rahman I. "Lung cancer and its association with chronic obstructive pulmonary disease: update on nexus of epigenetics." Current opinion in pulmonary medicine.. 2011 Jul 0; 17(4):279-85.

5/2011
Londhe VA, Sundar IK, Lopez B, Maisonet TM, Yu Y, Aghai ZH, Rahman I. "Hyperoxia impairs alveolar formation and induces senescence through decreased histone deacetylase activity and up-regulation of p21 in neonatal mouse lung." Pediatric research.. 2011 May 0; 69(5 Pt 1):371-7.

3/4/2011
Sundar IK, Hwang JW, Wu S, Sun J, Rahman I. "Deletion of vitamin D receptor leads to premature emphysema/COPD by increased matrix metalloproteinases and lymphoid aggregates formation." Biochemical and biophysical research communications.. 2011 Mar 4; 406(1):127-33. Epub 2011 Feb 12.

2011
Chung S, Sundar IK, Hwang JW, Yull FE, Blackwell TS, Kinnula VL, Bulger M, Yao H, Rahman I. "NF-?B inducing kinase, NIK mediates cigarette smoke/TNF?-induced histone acetylation and inflammation through differential activation of IKKs." PloS one.. 2011 6(8):e23488. Epub 2011 Aug 24.

2011
Sundar IK, Rahman I. "Vitamin d and susceptibility of chronic lung diseases: role of epigenetics." Frontiers in pharmacology.. 2011 2:50. Epub 2011 Aug 30.

12/17/2010
Adenuga D, Caito S, Yao H, Sundar IK, Hwang JW, Chung S, Rahman I. "Nrf2 deficiency influences susceptibility to steroid resistance via HDAC2 reduction." Biochemical and biophysical research communications.. 2010 Dec 17; 403(3-4):452-6. Epub 2010 Nov 19.

10/2010
Sundar IK, Chung S, Hwang JW, Arunachalam G, Cook S, Yao H, Mazur W, Kinnula VL, Fisher AB, Rahman I. "Peroxiredoxin 6 differentially regulates acute and chronic cigarette smoke–mediated lung inflammatory response and injury." Experimental lung research.. 2010 Oct 0; 36(8):451-62.

8/31/2010
Yao H, Arunachalam G, Hwang JW, Chung S, Sundar IK, Kinnula VL, Crapo JD, Rahman I. "Extracellular superoxide dismutase protects against pulmonary emphysema by attenuating oxidative fragmentation of ECM." Proceedings of the National Academy of Sciences of the United States of America.. 2010 Aug 31; 107(35):15571-6. Epub 2010 Aug 16.

8/15/2010
Hwang JW, Chung S, Sundar IK, Yao H, Arunachalam G, McBurney MW, Rahman I. "Cigarette smoke-induced autophagy is regulated by SIRT1-PARP-1-dependent mechanism: implication in pathogenesis of COPD." Archives of biochemistry and biophysics.. 2010 Aug 15; 500(2):203-9. Epub 2010 May 20.

8/2010
Chung S, Sundar IK, Yao H, Ho YS, Rahman I. "Glutaredoxin 1 regulates cigarette smoke-mediated lung inflammation through differential modulation of I{kappa}B kinases in mice: impact on histone acetylation." American journal of physiology. Lung cellular and molecular physiology.. 2010 Aug 0; 299(2):L192-203. Epub 2010 May 14.

7/22/2010
Arunachalam G, Sundar IK, Hwang JW, Yao H, Rahman I. "Emphysema is associated with increased inflammation in lungs of atherosclerosis-prone mice by cigarette smoke: implications in comorbidities of COPD." Journal of inflammation (London, England). 2010 Jul 22; 7:34. Epub 2010 Jul 22.

2/26/2010
Arunachalam G, Yao H, Sundar IK, Caito S, Rahman I. "SIRT1 regulates oxidant- and cigarette smoke-induced eNOS acetylation in endothelial cells: Role of resveratrol." Biochemical and biophysical research communications.. 2010 Feb 26; 393(1):66-72. Epub 2010 Jan 25.

2/12/2010
Caito S, Hwang JW, Chung S, Yao H, Sundar IK, Rahman I. "PARP-1 inhibition does not restore oxidant-mediated reduction in SIRT1 activity." Biochemical and biophysical research communications.. 2010 Feb 12; 392(3):264-70. Epub 2010 Jan 10.

2/2010
Rajendrasozhan S, Chung S, Sundar IK, Yao H, Rahman I. "Targeted disruption of NF-{kappa}B1 (p50) augments cigarette smoke-induced lung inflammation and emphysema in mice: a critical role of p50 in chromatin remodeling." American journal of physiology. Lung cellular and molecular physiology.. 2010 Feb 0; 298(2):L197-209. Epub 2009 Dec 04.

2010
Sundar IK, Caito S, Yao H, Rahman I. "Oxidative stress, thiol redox signaling methods in epigenetics." Methods in enzymology.. 2010 474:213-44. Epub 2010 Jun 20.

11/1/2008
Sundar IK, Sakthivel N. "Advances in selectable marker genes for plant transformation." Journal of plant physiology.. 2008 Nov 1; 165(16):1698-716. Epub 2008 Sep 11.

9/2008
Meja KK, Rajendrasozhan S, Adenuga D, Biswas SK, Sundar IK, Spooner G, Marwick JA, Chakravarty P, Fletcher D, Whittaker P, Megson IL, Kirkham PA, Rahman I. "Curcumin restores corticosteroid function in monocytes exposed to oxidants by maintaining HDAC2." American journal of respiratory cell and molecular biology.. 2008 Sep 0; 39(3):312-23. Epub 2008 Apr 17.