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Isaac Kirubakaran Sundar, Ph.D.


Showing all 58 journal articles & 0 books available

Journal Articles

Passi M, Shahid S, Chockalingam S, Sundar IK, Packirisamy G. "Conventional and Nanotechnology Based Approaches to Combat Chronic Obstructive Pulmonary Disease: Implications for Chronic Airway Diseases." International journal of nanomedicine.. 2020 15:3803-3826. Epub 2020 May 28.

Sundar IK, Maremanda KP, Rahman I. "Mitochondrial dysfunction is associated with Miro1 reduction in lung epithelial cells by cigarette smoke." Toxicology letters.. 2019 Dec 15; 317:92-101. Epub 2019 Oct 05.

Maremanda KP, Sundar IK, Rahman I. "Protective role of mesenchymal stem cells and mesenchymal stem cell-derived exosomes in cigarette smoke-induced mitochondrial dysfunction in mice." Toxicology and applied pharmacology.. 2019 Oct 30; :114788. Epub 2019 Oct 30.

Wang Q, Khan NA, Muthumalage T, Lawyer GR, McDonough SR, Chuang TD, Gong M, Sundar IK, Rehan VK, Rahman I. "Dysregulated repair and inflammatory responses by e-cigarette-derived inhaled nicotine and humectant propylene glycol in a sex-dependent manner in mouse lung." . 2019 Oct 0; 1(10):609-623. Epub 2019 Aug 23.

Li D, Sundar IK, McIntosh S, Ossip DJ, Goniewicz ML, O'Connor RJ, Rahman I. "Association of smoking and electronic cigarette use with wheezing and related respiratory symptoms in adults: cross-sectional results from the Population Assessment of Tobacco and Health (PATH) study, wave 2." Tobacco control.. 2019 Feb 13; Epub 2019 Feb 13.

Khan NA, Yogeswaran S, Wang Q, Muthumalage T, Sundar IK, Rahman I. "Waterpipe smoke and e-cigarette vapor differentially affect circadian molecular clock gene expression in mouse lungs." PloS one.. 2019 14(2):e0211645. Epub 2019 Feb 27.

Sundar IK, Li D, Rahman I. "Small RNA-sequence analysis of plasma-derived extracellular vesicle miRNAs in smokers and patients with chronic obstructive pulmonary disease as circulating biomarkers." . 2019 8(1):1684816. Epub 2019 Nov 07.

Sundar IK, Rashid K, Gerloff J, Rangel-Moreno J, Li D, Rahman I. "Genetic ablation of histone deacetylase 2 leads to lung cellular senescence and lymphoid follicle formation in COPD/emphysema." FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2018 Sep 0; 32(9):4955-4971. Epub 2018 Apr 09.

Sundar IK, Rashid K, Gerloff J, Li D, Rahman I. "Genetic Ablation of p16 Does Not Protect against Cellular Senescence in Mouse Models of Chronic Obstructive Pulmonary Disease/Emphysema." American journal of respiratory cell and molecular biology.. 2018 Aug 0; 59(2):189-199.

Rashid K, Sundar IK, Gerloff J, Li D, Rahman I. "Lung cellular senescence is independent of aging in a mouse model of COPD/emphysema." Scientific reports.. 2018 Jun 13; 8(1):9023. Epub 2018 Jun 13.

Sundar IK, Sellix MT, Rahman I. "Redox regulation of circadian molecular clock in chronic airway diseases." Free radical biology & medicine.. 2018 May 1; 119:121-128. Epub 2017 Oct 31.

Khan NA, Sundar IK, Rahman I. "Strain- and sex-dependent pulmonary toxicity of waterpipe smoke in mouse." Physiological reports.. 2018 Feb 0; 6(3)

Javed F, Kellesarian SV, Sundar IK, Romanos GE, Rahman I. "Recent updates on electronic cigarette aerosol and inhaled nicotine effects on periodontal and pulmonary tissues." Oral diseases.. 2017 Nov 0; 23(8):1052-1057. Epub 2017 Mar 30.

Rahman I, De Cunto G, Sundar IK, Lungarella G. "Vulnerability and Genetic Susceptibility to Cigarette Smoke-Induced Emphysema in Mice." American journal of respiratory cell and molecular biology.. 2017 Sep 0; 57(3):270-271.

Lee H, Park JR, Kim WJ, Sundar IK, Rahman I, Park SM, Yang SR. "Blockade of RAGE ameliorates elastase-induced emphysema development and progression RAGE-DAMP signaling." FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2017 May 0; 31(5):2076-2089. Epub 2017 Feb 01.

Lei W, Lerner C, Sundar IK, Rahman I. "Myofibroblast differentiation and its functional properties are inhibited by nicotine and e-cigarette via mitochondrial OXPHOS complex III." Scientific reports.. 2017 Mar 3; 7:43213. Epub 2017 Mar 03.

Gerloff J, Sundar IK, Freter R, Sekera ER, Friedman AE, Robinson R, Pagano T, Rahman I. "Inflammatory Response and Barrier Dysfunction by Different e-Cigarette Flavoring Chemicals Identified by Gas Chromatography-Mass Spectrometry in e-Liquids and e-Vapors on Human Lung Epithelial Cells and Fibroblasts." Applied in vitro toxicology.. 2017 Mar 1; 3(1):28-40.

Muthumalage T, Prinz M, Ansah KO, Gerloff J, Sundar IK, Rahman I. "Inflammatory and Oxidative Responses Induced by Exposure to Commonly Used e-Cigarette Flavoring Chemicals and Flavored e-Liquids without Nicotine." Frontiers in physiology.. 2017 8:1130. Epub 2018 Jan 11.

Sundar IK, Rahman I. "Gene expression profiling of epigenetic chromatin modification enzymes and histone marks by cigarette smoke: implications for COPD and lung cancer." American journal of physiology. Lung cellular and molecular physiology.. 2016 Dec 1; 311(6):L1245-L1258. Epub 2016 Oct 28.

Sundar IK, Javed F, Romanos GE, Rahman I. "E-cigarettes and flavorings induce inflammatory and pro-senescence responses in oral epithelial cells and periodontal fibroblasts." Oncotarget.. 2016 Nov 22; 7(47):77196-77204.

Lerner CA, Rutagarama P, Ahmad T, Sundar IK, Elder A, Rahman I. "Electronic cigarette aerosols and copper nanoparticles induce mitochondrial stress and promote DNA fragmentation in lung fibroblasts." Biochemical and biophysical research communications.. 2016 Sep 2; 477(4):620-625. Epub 2016 Jun 23.

Lerner CA, Lei W, Sundar IK, Rahman I. "Genetic Ablation of CXCR2 Protects against Cigarette Smoke-Induced Lung Inflammation and Injury." Frontiers in pharmacology.. 2016 7:391. Epub 2016 Oct 25.

Yao H, Sundar IK, Huang Y, Gerloff J, Sellix MT, Sime PJ, Rahman I. "Disruption of Sirtuin 1-Mediated Control of Circadian Molecular Clock and Inflammation in Chronic Obstructive Pulmonary Disease." American journal of respiratory cell and molecular biology.. 2015 Dec 0; 53(6):782-92.

Sundar IK, Yao H, Sellix MT, Rahman I. "Circadian molecular clock in lung pathophysiology." American journal of physiology. Lung cellular and molecular physiology.. 2015 Nov 15; 309(10):L1056-75. Epub 2015 Sep 11.

Sundar IK, Yao H, Sellix MT, Rahman I. "Circadian clock-coupled lung cellular and molecular functions in chronic airway diseases." American journal of respiratory cell and molecular biology.. 2015 Sep 0; 53(3):285-90.

Ahmad T, Sundar IK, Lerner CA, Gerloff J, Tormos AM, Yao H, Rahman I. "Impaired mitophagy leads to cigarette smoke stress-induced cellular senescence: implications for chronic obstructive pulmonary disease." FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2015 Jul 0; 29(7):2912-29. Epub 2015 Mar 19.

Sundar IK, Ahmad T, Yao H, Hwang JW, Gerloff J, Lawrence BP, Sellix MT, Rahman I. "Influenza A virus-dependent remodeling of pulmonary clock function in a mouse model of COPD." Scientific reports.. 2015 Apr 29; 4:9927. Epub 2015 Apr 29.

Lerner CA, Sundar IK, Watson RM, Elder A, Jones R, Done D, Kurtzman R, Ossip DJ, Robinson R, McIntosh S, Rahman I. "Environmental health hazards of e-cigarettes and their components: Oxidants and copper in e-cigarette aerosols." Environmental pollution.. 2015 Mar 0; 198:100-7. Epub 2015 Jan 09.

Lerner CA, Sundar IK, Yao H, Gerloff J, Ossip DJ, McIntosh S, Robinson R, Rahman I. "Vapors produced by electronic cigarettes and e-juices with flavorings induce toxicity, oxidative stress, and inflammatory response in lung epithelial cells and in mouse lung." PloS one.. 2015 10(2):e0116732. Epub 2015 Feb 06.

Yao H, Sundar IK, Ahmad T, Lerner C, Gerloff J, Friedman AE, Phipps RP, Sime PJ, McBurney MW, Guarente LP, Rahman I. "SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism." American journal of physiology. Lung cellular and molecular physiology.. 2014 May 1; 306(9):L816-28. Epub 2014 Mar 14.

Rahman I, Sundar IK, Nevid MZ, Friedman AE. "Cigarette smoke induces distinct histone modifications in lung cells: implications for the pathogenesis of COPD and lung cancer." Journal of proteome research.. 2014 Feb 7; 13(2):982-96. Epub 2013 Dec 13.

Hwang JW, Sundar IK, Yao H, Sellix MT, Rahman I. "Circadian clock function is disrupted by environmental tobacco/cigarette smoke, leading to lung inflammation and injury via a SIRT1-BMAL1 pathway." FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2014 Jan 0; 28(1):176-94. Epub 2013 Sep 11.

Sundar IK, Yao H, Huang Y, Lyda E, Sime PJ, Sellix MT, Rahman I. "Serotonin and corticosterone rhythms in mice exposed to cigarette smoke and in patients with COPD: implication for COPD-associated neuropathogenesis." PloS one.. 2014 9(2):e87999. Epub 2014 Feb 10.

Yao H, Hwang JW, Sundar IK, Friedman AE, McBurney MW, Guarente LP, Gu W, Kinnula VL, Rahman I. "SIRT1 redresses the imbalance of tissue inhibitor of matrix metalloproteinase-1 and matrix metalloproteinase-9 in the development of mouse emphysema and human COPD." American journal of physiology. Lung cellular and molecular physiology.. 2013 Nov 1; 305(9):L615-24. Epub 2013 Sep 13.

Hwang JW, Yao H, Caito S, Sundar IK, Rahman I. "Redox regulation of SIRT1 in inflammation and cellular senescence." Free radical biology & medicine.. 2013 Aug 0; 61:95-110. Epub 2013 Mar 27.

Sundar IK, Yao H, Rahman I. "Oxidative stress and chromatin remodeling in chronic obstructive pulmonary disease and smoking-related diseases." Antioxidants & redox signaling.. 2013 May 20; 18(15):1956-71. Epub 2012 Nov 06.

Yao H, Sundar IK, Gorbunova V, Rahman I. "P21-PARP-1 pathway is involved in cigarette smoke-induced lung DNA damage and cellular senescence." PloS one.. 2013 8(11):e80007. Epub 2013 Nov 11.

Agarwal AR, Zhao L, Sancheti H, Sundar IK, Rahman I, Cadenas E. "Short-term cigarette smoke exposure induces reversible changes in energy metabolism and cellular redox status independent of inflammatory responses in mouse lungs." American journal of physiology. Lung cellular and molecular physiology.. 2012 Nov 15; 303(10):L889-98. Epub 2012 Oct 12.

Yao H, Chung S, Hwang JW, Rajendrasozhan S, Sundar IK, Dean DA, McBurney MW, Guarente L, Gu W, Rönty M, Kinnula VL, Rahman I. "SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice." The Journal of clinical investigation.. 2012 Jun 0; 122(6):2032-45. Epub 2012 May 01.

Sundar IK, Chung S, Hwang JW, Lapek JD, Bulger M, Friedman AE, Yao H, Davie JR, Rahman I. "Mitogen- and stress-activated kinase 1 (MSK1) regulates cigarette smoke-induced histone modifications on NF-?B-dependent genes." PloS one.. 2012 7(2):e31378. Epub 2012 Feb 01.

Hwang JW, Rajendrasozhan S, Yao H, Chung S, Sundar IK, Huyck HL, Pryhuber GS, Kinnula VL, Rahman I. "FOXO3 deficiency leads to increased susceptibility to cigarette smoke-induced inflammation, airspace enlargement, and chronic obstructive pulmonary disease." The Journal of immunology : official journal of the American Association of Immunologists.. 2011 Jul 15; 187(2):987-98. Epub 2011 Jun 20.

Sundar IK, Mullapudi N, Yao H, Spivack SD, Rahman I. "Lung cancer and its association with chronic obstructive pulmonary disease: update on nexus of epigenetics." Current opinion in pulmonary medicine.. 2011 Jul 0; 17(4):279-85.

Londhe VA, Sundar IK, Lopez B, Maisonet TM, Yu Y, Aghai ZH, Rahman I. "Hyperoxia impairs alveolar formation and induces senescence through decreased histone deacetylase activity and up-regulation of p21 in neonatal mouse lung." Pediatric research.. 2011 May 0; 69(5 Pt 1):371-7.

Sundar IK, Hwang JW, Wu S, Sun J, Rahman I. "Deletion of vitamin D receptor leads to premature emphysema/COPD by increased matrix metalloproteinases and lymphoid aggregates formation." Biochemical and biophysical research communications.. 2011 Mar 4; 406(1):127-33. Epub 2011 Feb 12.

Chung S, Sundar IK, Hwang JW, Yull FE, Blackwell TS, Kinnula VL, Bulger M, Yao H, Rahman I. "NF-?B inducing kinase, NIK mediates cigarette smoke/TNF?-induced histone acetylation and inflammation through differential activation of IKKs." PloS one.. 2011 6(8):e23488. Epub 2011 Aug 24.

Sundar IK, Rahman I. "Vitamin d and susceptibility of chronic lung diseases: role of epigenetics." Frontiers in pharmacology.. 2011 2:50. Epub 2011 Aug 30.

Adenuga D, Caito S, Yao H, Sundar IK, Hwang JW, Chung S, Rahman I. "Nrf2 deficiency influences susceptibility to steroid resistance via HDAC2 reduction." Biochemical and biophysical research communications.. 2010 Dec 17; 403(3-4):452-6. Epub 2010 Nov 19.

Sundar IK, Chung S, Hwang JW, Arunachalam G, Cook S, Yao H, Mazur W, Kinnula VL, Fisher AB, Rahman I. "Peroxiredoxin 6 differentially regulates acute and chronic cigarette smoke–mediated lung inflammatory response and injury." Experimental lung research.. 2010 Oct 0; 36(8):451-62.

Yao H, Arunachalam G, Hwang JW, Chung S, Sundar IK, Kinnula VL, Crapo JD, Rahman I. "Extracellular superoxide dismutase protects against pulmonary emphysema by attenuating oxidative fragmentation of ECM." Proceedings of the National Academy of Sciences of the United States of America.. 2010 Aug 31; 107(35):15571-6. Epub 2010 Aug 16.

Hwang JW, Chung S, Sundar IK, Yao H, Arunachalam G, McBurney MW, Rahman I. "Cigarette smoke-induced autophagy is regulated by SIRT1-PARP-1-dependent mechanism: implication in pathogenesis of COPD." Archives of biochemistry and biophysics.. 2010 Aug 15; 500(2):203-9. Epub 2010 May 20.

Chung S, Sundar IK, Yao H, Ho YS, Rahman I. "Glutaredoxin 1 regulates cigarette smoke-mediated lung inflammation through differential modulation of I{kappa}B kinases in mice: impact on histone acetylation." American journal of physiology. Lung cellular and molecular physiology.. 2010 Aug 0; 299(2):L192-203. Epub 2010 May 14.

Arunachalam G, Sundar IK, Hwang JW, Yao H, Rahman I. "Emphysema is associated with increased inflammation in lungs of atherosclerosis-prone mice by cigarette smoke: implications in comorbidities of COPD." Journal of inflammation (London, England). 2010 Jul 22; 7:34. Epub 2010 Jul 22.

Arunachalam G, Yao H, Sundar IK, Caito S, Rahman I. "SIRT1 regulates oxidant- and cigarette smoke-induced eNOS acetylation in endothelial cells: Role of resveratrol." Biochemical and biophysical research communications.. 2010 Feb 26; 393(1):66-72. Epub 2010 Jan 25.

Caito S, Hwang JW, Chung S, Yao H, Sundar IK, Rahman I. "PARP-1 inhibition does not restore oxidant-mediated reduction in SIRT1 activity." Biochemical and biophysical research communications.. 2010 Feb 12; 392(3):264-70. Epub 2010 Jan 10.

Rajendrasozhan S, Chung S, Sundar IK, Yao H, Rahman I. "Targeted disruption of NF-{kappa}B1 (p50) augments cigarette smoke-induced lung inflammation and emphysema in mice: a critical role of p50 in chromatin remodeling." American journal of physiology. Lung cellular and molecular physiology.. 2010 Feb 0; 298(2):L197-209. Epub 2009 Dec 04.

Sundar IK, Caito S, Yao H, Rahman I. "Oxidative stress, thiol redox signaling methods in epigenetics." Methods in enzymology.. 2010 474:213-44. Epub 2010 Jun 20.

Sundar IK, Sakthivel N. "Advances in selectable marker genes for plant transformation." Journal of plant physiology.. 2008 Nov 1; 165(16):1698-716. Epub 2008 Sep 11.

Meja KK, Rajendrasozhan S, Adenuga D, Biswas SK, Sundar IK, Spooner G, Marwick JA, Chakravarty P, Fletcher D, Whittaker P, Megson IL, Kirkham PA, Rahman I. "Curcumin restores corticosteroid function in monocytes exposed to oxidants by maintaining HDAC2." American journal of respiratory cell and molecular biology.. 2008 Sep 0; 39(3):312-23. Epub 2008 Apr 17.