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Ethan David Cohen, Ph.D.

Contact Information

Phone Numbers

Administrative: (585) 276-4994

Office: (585) 276-5898

Fax: (585) 275-1288

Biography

Professional Background

Dr. Cohen graduated cum laud from Lebanon Valley College before completing both his graduate and postdoctoral research at the University of Pennsylvania School of Medicine. Dr. Cohen's research is largely focused on understanding how intercellular signaling directs cardiac morphogenesis and how defect in this signaling contribute to human disease. Congenital heart defects are present in approximately 1% of newborn babies, 10% of stillborn fetuses and responsible for nearly 6% of deaths among children under one year of age. Furthermore heart disease is the leading cause of death among adults in the Western world. A better understanding of the mechanisms underlying cardiac development will aid in the discovery of new methods to detect and treat congenital heart defects. Moreover since aberrant signaling by embryonic pathways is often associated with disease, this same information will also aid in the discovery of novel treatments for adult cardiomyopathy. Many of these new treatments are likely to involve using stem/progenitor cells to replace damaged cardiac tissues. However our ability to differentiate multi-potent stem cells into functional cardiomyocytes is still limited and further insight into the molecular cues that guide cardiac development will be necessary to reach the full potential of regenerative medicine.

Research

Dr. Cohen graduated cum laud from Lebanon Valley College before completing both his graduate and postdoctoral research at the University of Pennsylvania School of Medicine. Dr. Cohen's research is largely focused on understanding how intercellular signaling directs cardiac morphogenesis and how defect in this signaling contribute to human disease. Congenital heart defects are present in approximately 1% of newborn babies, 10% of stillborn fetuses and responsible for nearly 6% of deaths among children under one year of age. Furthermore heart disease is the leading cause of death among adults in the Western world. A better understanding of the mechanisms underlying cardiac development will aid in the discovery of new methods to detect and treat congenital heart defects. Moreover since aberrant signaling by embryonic pathways is often associated with disease, this same information will also aid in the discovery of novel treatments for adult cardiomyopathy. Many of these new treatments are likely to involve using stem/progenitor cells to replace damaged cardiac tissues. However our ability to differentiate multi-potent stem cells into functional cardiomyocytes is still limited and further insight into the molecular cues that guide cardiac development will be necessary to reach the full potential of regenerative medicine.

Credentials

Faculty Appointments

Education

1997
BS | Lebanon Valley College
Biochemistry

2004
Ph.D. | University of Pennsylvania, School of Medicine
Biomedical Graduate Studies

2004
PhD | Univ Pennsylvania Sch Medicine
Cell and Molecular Biology

Awards

2015 - 2107
American Heart Association Grant-in-Aid Award

2008
Holtzer Prize for outstanding postdoctoral research in cell and developmental biology at the University of Prnnsylvaniea
Location: University of Pennsylvania

2002
The Susan Heyner Award for Excellence in Research

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Publications

Journal Articles

12/1/2015
Ajima R, Bisson JA, Jay-Christian Helt , Nakaya MA, Habas R, Tessarollo L, He X, Morrisey EE, Yamaguchi TP, Cohen ED. "DAAM1 and DAAM2 are co-required for myocardial maturation and sarcomere assembly." Developmental biology.. 2015 Dec 1; 408(1):126-39. Epub 2015 Oct 23.

2/1/2015
Bisson JA, Mills B, Paul Helt JC, Zwaka TP, Cohen ED. "Wnt5a and Wnt11 inhibit the canonical Wnt pathway and promote cardiac progenitor development via the Caspase-dependent degradation of AKT." Developmental biology.. 2015 Feb 1; 398(1):80-96. Epub 2014 Dec 05.

8/26/2014
Kadzik RS, Cohen ED, Morley MP, Stewart KM, Lu MM, Morrisey EE. "Wnt ligand/Frizzled 2 receptor signaling regulates tube shape and branch-point formation in the lung through control of epithelial cell shape." Proceedings of the National Academy of Sciences of the United States of America.. 2014 Aug 26; 111(34):12444-9. Epub 2014 Aug 11.

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