John J. Krolewski, M.D., Ph.D., is Professor of Pathology and Laboratory Medicine at the University of Rochester Medical Center. Dr. Krolewski is a physician-scientist whose academic interests include investigating the molecular mechanisms of cancer, and the application of clinical 'next-gen' sequencing. Dr. Krolewski received his undergraduate degree from M.I.T. and was an NIH MSTP fellow at New York University School of Medicine, receiving his M.D.-Ph.D. in 1984. He completed his pathology residency training at N.Y.U. in 1988.
Dr. Krolewski joined the faculty in the Pathology Department at Columbia University, College of P&S in 1990 and then moved to the University of California IRVINE School of Medicine in 1998, before coming to Rochester as Chair in July 2012.
He previously established Molecular Pathology clinical laboratories at both Columbia and UC Irvine and has had an NIH funded program in cancer biology since 1992. His clinical interests are focused on the application of clinical genotyping technologies, such as the use of next-generation sequencing, to assist physicians in diagnoses, and to tailor treatment to each patient's specific genotype or cancer defect. The current focus of his research program is on the mechanisms of prostate cancer cell death with a goal of translating this knowledge into novel pro-apoptotic therapies for prostate cancer.
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