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Joe V. Chakkalakal, Ph.D.

Contact Information

Phone Numbers

Office: (585) 273-5631

Fax: (585) 273-2652

Research Labs

Faculty Appointments

Biography

Research

Dr. Joe Chakkalakal is a Dean's Associate Professor in the Department of Pharmacology and Physiology affiliated with the Wilmot Cancer Center at the University Rochester Medical Center. His laboratory is interested in the contribution of stem cells to the maturation, regeneration, and lifelong maintenance of skeletal muscle in various contexts including juvenile growth, aging, and cancer survivorship.

Through the use of conditional genetic strategies Dr. Chakkalakal's lab has uncovered niche derived signals responsible for the age-related decline of skeletal muscle resident stem cells. More recently, the Chakkalakal lab has found resident stem cell loss or gain is associated with earlier onset or attenuation of age-related skeletal muscle decline respectively. Dr. Chakkalakal's lab is interested in building on these observations to:

1. Uncover how resident stem cell manipulation affects specific aspects of skeletal muscle biology in models of post-natal maturation, aging, accelerated aging and cancer survivorship

2. Identify therapies that promote resident stem cell maintenance and function

Credentials

Education

2000
BSc | York University
Kinesiology and Health Sciences

2006
PhD | University of Ottawa
Cellular and Molecular Medicine

Post-doctoral Training & Residency

2010 - 2012
Postdoctoral Fellow, Regenerative Medicine, Massachusetts General Hospital

2006 - 2009
Postdoctoral Fellow, Molecular and Cellular Biology, Harvard University

Awards

2018 - 2023
Dean's Associate Professorship
Sponsor: School of Medicine and Dentistry
Location: University of Rochester Medical Center

2005
Award of Excellence PhD
Sponsor: Cellular and Molecular Medicine
Location: University of Ottawa

2000
Tait McKenzie Honor Society
Sponsor: Kinesiology and Health Sciences
Location: York University

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Publications

Journal Articles

7/29/2021
Larouche J, Mohiuddin M, Choi JJ, Ulintz PJ, Fraczek PM, Sabin K, Pitchiaya S, Kurpiers SJ, Castor-Macias J, Liu W, Hastings RL, Brown LA, Markworth JF, De Silva K, Levi BD, Merajver SD, Valdez G, Chakkalakal JV, Jang Y, Brooks S, Aguilar CA. "Murine muscle stem cell response to perturbations of the neuromuscular junction are attenuated with aging." eLife.. 2021 Jul 29; 10Epub 2021 Jul 29.

5/7/2021
Cole CL, Bachman JF, Ye J, Murphy J, Gerber SA, Beck CA, Boyce BF, Muthukrishnan G, Chakkalakal JV, Schwarz EM, Linehan D. "Increased myocellular lipid and IGFBP-3 expression in a pre-clinical model of pancreatic cancer-related skeletal muscle wasting." Journal of cachexia, sarcopenia and muscle.. 2021 May 7; Epub 2021 May 07.

4/2/2021
Bachman JF, Chakkalakal JV. "Insights into muscle stem cell dynamics during postnatal development." The FEBS journal.. 2021 Apr 2; Epub 2021 Apr 02.

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