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Joe V. Chakkalakal, Ph.D.

Contact Information

Phone Numbers

Office: (585) 273-5631

Fax: (585) 273-2652

Research Labs

Faculty Appointments



Dr. Joe Chakkalakal is a Dean's Associate Professor in the Department of Pharmacology and Physiology affiliated with the Wilmot Cancer Center at the University Rochester Medical Center. His laboratory is interested in the contribution of stem cells to the maturation, regeneration, and lifelong maintenance of skeletal muscle in various contexts including juvenile growth, aging, and cancer survivorship.

Through the use of conditional genetic strategies Dr. Chakkalakal's lab has uncovered niche derived signals responsible for the age-related decline of skeletal muscle resident stem cells. More recently, the Chakkalakal lab has found resident stem cell loss or gain is associated with earlier onset or attenuation of age-related skeletal muscle decline respectively. Dr. Chakkalakal's lab is interested in building on these observations to:

1. Uncover how resident stem cell manipulation affects specific aspects of skeletal muscle biology in models of post-natal maturation, aging, accelerated aging and cancer survivorship

2. Identify therapies that promote resident stem cell maintenance and function



BSc | York University
Kinesiology and Health Sciences

PhD | University of Ottawa
Cellular and Molecular Medicine

Post-doctoral Training & Residency

2010 - 2012
Postdoctoral Fellow, Regenerative Medicine, Massachusetts General Hospital

2006 - 2009
Postdoctoral Fellow, Molecular and Cellular Biology, Harvard University


2018 - 2023
Dean's Associate Professorship
Sponsor: School of Medicine and Dentistry
Location: University of Rochester Medical Center

Award of Excellence PhD
Sponsor: Cellular and Molecular Medicine
Location: University of Ottawa

Tait McKenzie Honor Society
Sponsor: Kinesiology and Health Sciences
Location: York University

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Journal Articles

Pan C, Jaiswal Agrawal N, Zulia Y, Singh S, Sha K, Mohler JL, Eng KH, Chakkalakal J, Krolewski JJ, Nastiuk KL. "Prostate tumor-derived GDF11 accelerates androgen deprivation therapy-induced sarcopenia." JCI insight.. 2020 Feb 20; Epub 2020 Feb 20.

Yue L, Talukder MAH, Gurjar A, Lee JI, Noble M, Dirksen RT, Chakkalakal J, Elfar JC. "4-Aminopyridine attenuates muscle atrophy after sciatic nerve crush injury in mice." Muscle & nerve.. 2019 May 15; Epub 2019 May 15.

Bell DR, Wu E, Rudmann C, Forney M, Kaiser C, Wood R, Chakkalakal J, Paris N, Klose A, Xiao GQ, Rangel-Moreno J, Garcia-Hernandez M, Ritchlin C, Schwarz E, Rahimi H. "Selective sexual dimorphism in musculoskeletal-cardiopulmonary pathologies and mortality in the TNF-transgenic mouse model of rheumatoid arthritis." Arthritis & rheumatology.. 2019 Apr 10; Epub 2019 Apr 10.