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Joe V. Chakkalakal, Ph.D.

Contact Information

Phone Numbers

Office: (585) 273-5631

Fax: (585) 273-2652

Research Labs

Faculty Appointments



Dr. Joe Chakkalakal is a Dean's Associate Professor in the Department of Pharmacology and Physiology affiliated with the Wilmot Cancer Center at the University Rochester Medical Center. His laboratory is interested in the contribution of stem cells to the maturation, regeneration, and lifelong maintenance of skeletal muscle in various contexts including juvenile growth, aging, and cancer survivorship.

Through the use of conditional genetic strategies Dr. Chakkalakal's lab has uncovered niche derived signals responsible for the age-related decline of skeletal muscle resident stem cells. More recently, the Chakkalakal lab has found resident stem cell loss or gain is associated with earlier onset or attenuation of age-related skeletal muscle decline respectively. Dr. Chakkalakal's lab is interested in building on these observations to:

1. Uncover how resident stem cell manipulation affects specific aspects of skeletal muscle biology in models of post-natal maturation, aging, accelerated aging and cancer survivorship

2. Identify therapies that promote resident stem cell maintenance and function



BSc | York University
Kinesiology and Health Sciences

PhD | University of Ottawa
Cellular and Molecular Medicine

Post-doctoral Training & Residency

2010 - 2012
Postdoctoral Fellow, Regenerative Medicine, Massachusetts General Hospital

2006 - 2009
Postdoctoral Fellow, Molecular and Cellular Biology, Harvard University


2018 - 2023
Dean's Associate Professorship
Sponsor: School of Medicine and Dentistry
Location: University of Rochester Medical Center

Award of Excellence PhD
Sponsor: Cellular and Molecular Medicine
Location: University of Ottawa

Tait McKenzie Honor Society
Sponsor: Kinesiology and Health Sciences
Location: York University

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Journal Articles

Bachman JF, Chakkalakal JV. "Insights into muscle stem cell dynamics during postnatal development." The FEBS journal.. 2021 Apr 2; Epub 2021 Apr 02.

Bachman JF, Blanc RS, Paris ND, Kallenbach JG, Johnston CJ, Hernady E, Williams JP, Chakkalakal JV. "Radiation-Induced Damage to Prepubertal Pax7+ Skeletal Muscle Stem Cells Drives Lifelong Deficits in Myofiber Size and Nuclear Number." iScience.. 2020 Nov 20; 23(11):101760. Epub 2020 Nov 02.

Paris ND, Kallenbach JG, Bachman JF, Blanc RS, Johnston CJ, Hernady E, Williams JP, Chakkalakal JV. "Chemoradiation impairs myofiber hypertrophic growth in a pediatric tumor model." Scientific reports.. 2020 Nov 11; 10(1):19501. Epub 2020 Nov 11.