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Joe V. Chakkalakal, Ph.D.

Publications

Showing all 39 journal articles & 0 books available

Journal Articles

7/29/2021
Larouche J, Mohiuddin M, Choi JJ, Ulintz PJ, Fraczek PM, Sabin K, Pitchiaya S, Kurpiers SJ, Castor-Macias J, Liu W, Hastings RL, Brown LA, Markworth JF, De Silva K, Levi BD, Merajver SD, Valdez G, Chakkalakal JV, Jang Y, Brooks S, Aguilar CA. "Murine muscle stem cell response to perturbations of the neuromuscular junction are attenuated with aging." eLife.. 2021 Jul 29; 10Epub 2021 Jul 29.

5/7/2021
Cole CL, Bachman JF, Ye J, Murphy J, Gerber SA, Beck CA, Boyce BF, Muthukrishnan G, Chakkalakal JV, Schwarz EM, Linehan D. "Increased myocellular lipid and IGFBP-3 expression in a pre-clinical model of pancreatic cancer-related skeletal muscle wasting." Journal of cachexia, sarcopenia and muscle.. 2021 May 7; Epub 2021 May 07.

4/2/2021
Bachman JF, Chakkalakal JV. "Insights into muscle stem cell dynamics during postnatal development." The FEBS journal.. 2021 Apr 2; Epub 2021 Apr 02.

11/20/2020
Bachman JF, Blanc RS, Paris ND, Kallenbach JG, Johnston CJ, Hernady E, Williams JP, Chakkalakal JV. "Radiation-Induced Damage to Prepubertal Pax7+ Skeletal Muscle Stem Cells Drives Lifelong Deficits in Myofiber Size and Nuclear Number." iScience.. 2020 Nov 20; 23(11):101760. Epub 2020 Nov 02.

11/11/2020
Paris ND, Kallenbach JG, Bachman JF, Blanc RS, Johnston CJ, Hernady E, Williams JP, Chakkalakal JV. "Chemoradiation impairs myofiber hypertrophic growth in a pediatric tumor model." Scientific reports.. 2020 Nov 11; 10(1):19501. Epub 2020 Nov 11.

8/20/2020
Blanc RS, Kallenbach JG, Bachman JF, Mitchell A, Paris ND, Chakkalakal JV. "Inhibition of inflammatory CCR2 signaling promotes aged muscle regeneration and strength recovery after injury." Nature communications.. 2020 Aug 20; 11(1):4167. Epub 2020 Aug 20.

4/8/2020
Li J, Yi X, Yao Z, Chakkalakal JV, Xing L, Boyce BF. "TNF Receptor-Associated Factor 6 Mediates TNF?-Induced Skeletal Muscle Atrophy in Mice During Aging." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2020 Apr 8; Epub 2020 Apr 08.

2/20/2020
Pan C, Jaiswal Agrawal N, Zulia Y, Singh S, Sha K, Mohler JL, Eng KH, Chakkalakal J, Krolewski JJ, Nastiuk KL. "Prostate tumor-derived GDF11 accelerates androgen deprivation therapy-induced sarcopenia." JCI insight.. 2020 Feb 20; Epub 2020 Feb 20.

5/15/2019
Yue L, Talukder MAH, Gurjar A, Lee JI, Noble M, Dirksen RT, Chakkalakal J, Elfar JC. "4-Aminopyridine attenuates muscle atrophy after sciatic nerve crush injury in mice." Muscle & nerve.. 2019 May 15; Epub 2019 May 15.

4/10/2019
Bell DR, Wu E, Rudmann C, Forney M, Kaiser C, Wood R, Chakkalakal J, Paris N, Klose A, Xiao GQ, Rangel-Moreno J, Garcia-Hernandez M, Ritchlin C, Schwarz E, Rahimi H. "Selective sexual dimorphism in musculoskeletal-cardiopulmonary pathologies and mortality in the TNF-transgenic mouse model of rheumatoid arthritis." Arthritis & rheumatology.. 2019 Apr 10; Epub 2019 Apr 10.

2019
Richard D Bell; Emily K Wu; Christopher A Rudmann; Megan Forney; Claire R W Kaiser; Ronald W Wood; Joe V Chakkalakal; Nicole D Paris; Alanna Klose; Guang-Qian Xiao; Javier Rangel-Moreno; Maria L Garcia-Hernandez; Christopher T Ritchlin; Edward M Schwarz; Homaira Rahimi. "Selective sexual dimorphism in musculoskeletal-cardiopulmonary pathologies and mortality in the TNF Transgenic mouse model of rheumatoid arthritis". Arthritis & Rheumatology. 2019; .

10/25/2018
Bachman JF, Klose A, Liu W, Paris ND, Blanc RS, Schmalz M, Knapp E, Chakkalakal JV. "Prepubertal skeletal muscle growth requires Pax7-expressing satellite cell-derived myonuclear contribution." Development.. 2018 Oct 25; 145(20)Epub 2018 Oct 25.

2018
Liu W, Chakkalakal JV. "The Composition, Development, and Regeneration of Neuromuscular Junctions." Current topics in developmental biology.. 2018 126:99-124. Epub 2017 Nov 10.

2018
Klose A, Liu W, Paris ND, Forman S, Krolewski JJ, Nastiuk KL, Chakkalakal JV. "Castration induces satellite cell activation that contributes to skeletal muscle maintenance." JCSM rapid communications.. 2018 1(1)

12/2017
Dunne RF, Mustian KM, Garcia JM, Dale W, Hayward R, Roussel B, Buschmann MM, Caan BJ, Cole CL, Fleming FJ, Chakkalakal JV, Linehan DC, Hezel AF, Mohile SG. "Research priorities in cancer cachexia: The University of Rochester Cancer Center NCI Community Oncology Research Program Research Base Symposium on Cancer Cachexia and Sarcopenia." Current opinion in supportive and palliative care.. 2017 Dec 0; 11(4):278-286.

6/6/2017
Liu W, Klose A, Forman S, Paris ND, Wei-LaPierre L, Cortés-Lopéz M, Tan A, Flaherty M, Miura P, Dirksen RT, Chakkalakal JV. "Loss of adult skeletal muscle stem cells drives age-related neuromuscular junction degeneration." eLife.. 2017 Jun 6; 6Epub 2017 Jun 06.

11/18/2016
Paris ND, Soroka A, Klose A, Liu W, Chakkalakal JV. "Smad4 restricts differentiation to promote expansion of satellite cell derived progenitors during skeletal muscle regeneration." eLife.. 2016 Nov 18; 5Epub 2016 Nov 18.

11/2016
Pan C, Singh S, Sahasrabudhe DM, Chakkalakal JV, Krolewski JJ, Nastiuk KL. "TGF? Superfamily Members Mediate Androgen Deprivation Therapy-Induced Obese Frailty in Male Mice." Endocrinology.. 2016 Nov 0; 157(11):4461-4472. Epub 2016 Sep 09.

7/2016
Williams JP, Calvi L, Chakkalakal JV, Finkelstein JN, O'Banion MK, Puzas E. "Addressing the Symptoms or Fixing the Problem? Developing Countermeasures against Normal Tissue Radiation Injury." Radiation research.. 2016 Jul 0; 186(1):1-16. Epub 2016 Jun 22.

8/27/2015
Liu W, Wei-LaPierre L, Klose A, Dirksen RT, Chakkalakal JV. "Inducible depletion of adult skeletal muscle stem cells impairs the regeneration of neuromuscular junctions." eLife.. 2015 Aug 27; 4Epub 2015 Aug 27.

4/2014
Chakkalakal JV, Christensen J, Xiang W, Tierney MT, Boscolo FS, Sacco A, Brack AS. "Early forming label-retaining muscle stem cells require p27kip1 for maintenance of the primitive state." Development.. 2014 Apr 0; 141(8):1649-59.

10/18/2012
Chakkalakal JV, Jones KM, Basson MA, Brack AS. "The aged niche disrupts muscle stem cell quiescence." Nature.. 2012 Oct 18; 490(7420):355-60. Epub 2012 Sep 26.

9/26/2012
Chakkalakal J, Brack A. "Extrinsic Regulation of Satellite Cell Function and Muscle Regeneration Capacity during Aging." Journal of stem cell research & therapy.. 2012 Sep 26; Suppl 11:001.

1/2012
Chakkalakal JV, Kuang S, Buffelli M, Lichtman JW, Sanes JR. "Mouse transgenic lines that selectively label Type I, Type IIA, and Types IIX+B skeletal muscle fibers." Genesis : the journal of genetics and development.. 2012 Jan 0; 50(1):50-8. Epub 2012 Jan 06.

10/2010
Chakkalakal JV, Nishimune H, Ruas JL, Spiegelman BM, Sanes JR. "Retrograde influence of muscle fibers on their innervation revealed by a novel marker for slow motoneurons." Development.. 2010 Oct 0; 137(20):3489-99. Epub 2010 Sep 15.

12/1/2009
Miura P, Chakkalakal JV, Boudreault L, Bélanger G, Hébert RL, Renaud JM, Jasmin BJ. "Pharmacological activation of PPARbeta/delta stimulates utrophin A expression in skeletal muscle fibers and restores sarcolemmal integrity in mature mdx mice." Human molecular genetics.. 2009 Dec 1; 18(23):4640-9. Epub 2009 Sep 10.

2/2008
Chakkalakal JV, Miura P, Bélanger G, Michel RN, Jasmin BJ. "Modulation of utrophin A mRNA stability in fast versus slow muscles via an AU-rich element and calcineurin signaling." Nucleic acids research.. 2008 Feb 0; 36(3):826-38. Epub 2007 Dec 15.

10/2007
Michel RN, Chin ER, Chakkalakal JV, Eibl JK, Jasmin BJ. "Ca2+/calmodulin-based signalling in the regulation of the muscle fibre phenotype and its therapeutic potential via modulation of utrophin A and myostatin expression." Applied physiology, nutrition, and metabolism = Physiologie appliquée, nutrition et métabolisme.. 2007 Oct 0; 32(5):921-9.

5/1/2006
Chakkalakal JV, Michel SA, Chin ER, Michel RN, Jasmin BJ. "Targeted inhibition of Ca2+ /calmodulin signaling exacerbates the dystrophic phenotype in mdx mouse muscle." Human molecular genetics.. 2006 May 1; 15(9):1423-35. Epub 2006 Mar 21.

10/2005
Angus LM, Chakkalakal JV, Méjat A, Eibl JK, Bélanger G, Megeney LA, Chin ER, Schaeffer L, Michel RN, Jasmin BJ. "Calcineurin-NFAT signaling, together with GABP and peroxisome PGC-1{alpha}, drives utrophin gene expression at the neuromuscular junction." American journal of physiology. Cell physiology.. 2005 Oct 0; 289(4):C908-17. Epub 2005 Jun 01.

9/23/2005
Miura P, Thompson J, Chakkalakal JV, Holcik M, Jasmin BJ. "The utrophin A 5'-untranslated region confers internal ribosome entry site-mediated translational control during regeneration of skeletal muscle fibers." The Journal of biological chemistry.. 2005 Sep 23; 280(38):32997-3005. Epub 2005 Aug 01.

6/2005
Stocksley MA, Chakkalakal JV, Bradford A, Miura P, De Repentigny Y, Kothary R, Jasmin BJ. "A 1.3 kb promoter fragment confers spatial and temporal expression of utrophin A mRNA in mouse skeletal muscle fibers." Neuromuscular disorders : NMD.. 2005 Jun 0; 15(6):437-49.

6/2005
Chakkalakal JV, Thompson J, Parks RJ, Jasmin BJ. "Molecular, cellular, and pharmacological therapies for Duchenne/Becker muscular dystrophies." FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2005 Jun 0; 19(8):880-91.

12/2004
St-Pierre SJ, Chakkalakal JV, Kolodziejczyk SM, Knudson JC, Jasmin BJ, Megeney LA. "Glucocorticoid treatment alleviates dystrophic myofiber pathology by activation of the calcineurin/NF-AT pathway." FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2004 Dec 0; 18(15):1937-9. Epub 2004 Sep 29.

2/15/2004
Chakkalakal JV, Harrison MA, Carbonetto S, Chin E, Michel RN, Jasmin BJ. "Stimulation of calcineurin signaling attenuates the dystrophic pathology in mdx mice." Human molecular genetics.. 2004 Feb 15; 13(4):379-88. Epub 2003 Dec 17.

6/24/2003
Chakkalakal JV, Stocksley MA, Harrison MA, Angus LM, Deschenes-Furry J, St-Pierre S, Megeney LA, Chin ER, Michel RN, Jasmin BJ. "Expression of utrophin A mRNA correlates with the oxidative capacity of skeletal muscle fiber types and is regulated by calcineurin/NFAT signaling." Proceedings of the National Academy of Sciences of the United States of America.. 2003 Jun 24; 100(13):7791-6. Epub 2003 Jun 13.

1/2003
Chakkalakal JV, Jasmin BJ. "Localizing synaptic mRNAs at the neuromuscular junction: it takes more than transcription." BioEssays : news and reviews in molecular, cellular and developmental biology.. 2003 Jan 0; 25(1):25-31.

2002
Jasmin BJ, Angus LM, Bélanger G, Chakkalakal JV, Gramolini AO, Lunde JA, Stocksley MA, Thompson J. "Multiple regulatory events controlling the expression and localization of utrophin in skeletal muscle fibers: insights into a therapeutic strategy for Duchenne muscular dystrophy." Journal of physiology, Paris.. 2002 96(1-2):31-42.

10/2001
Gramolini AO, Bélanger G, Thompson JM, Chakkalakal JV, Jasmin BJ. "Increased expression of utrophin in a slow vs. a fast muscle involves posttranscriptional events." American journal of physiology. Cell physiology.. 2001 Oct 0; 281(4):C1300-9.