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Jian Zhu, Ph.D.

Contact Information

Phone Numbers

Administrative: (585) 275-3402

Fax: (585) 473-9573

Office: (585) 275-6916

Research Labs

Biography

Research

Virus and host are equivalent opponents and have been playing a dynamic and "never-ending" match for a long time. Virus highly depends on host cellular machineries to replicate, while host cells develop multi-layered antiviral mechanisms to control or prevent viral invasion. Short-term acute or long-term chronic viral infection might yield different yet complicated consequences in host cells. Our lab studies the host-virus interactions, particularly for HIV and herpesviruses, by using recently developed, "state-of-the-art", multidisciplinary systematic approaches. We work at the interface of virology, immunology, cellular and molecular biology, proteomics, and functional genomics. The goal is to not only pinpoint key genes that play a role in viral replication or mediate the consequences of viral infection for further dissection of their mechanistic functions using classic cell and/or animal models, but also construct a global landscape of gene network modulating viral infection from the massive data generated by integrative multiple systematic approaches at a higher resolution with the aid of powerful bioinformatic analyses. Currently, one of our major directions is to identify key host factors that regulate viral latency and reactivation for HIV and herpesviruses, by combining the genome-wide RNA interference (RNAi) screening together with various modern proteomic approaches including our recently developed PLATO (ParalleL Analysis of Translated ORFs) synthetic display method. Meanwhile, we're also interested in improving current systematic approaches or developing new ones to facilitate the study of host-virus interactions at various (genetic, biochemical and serological) levels, as well as to improve such study at a more quantitative, dynamic, and in vivo setting. Continuing to improve systematic approaches will increase their reliability and accuracy for better applications reaching a greater scope and depth of current host-virus studies. With more advanced systematic tools we will be led towards a complete understanding of viral pathogenesis, antiviral defense mechanisms, and their consequences in critical diseases such as cancer and autoimmunity.

Credentials

Faculty Appointments

Education

2009
PhD | The Johns Hopkins University School of Medicine
Pharmacology

2000
BS (summa cum laude) | Health Science Center, Peking University
Pharmacology

2013
Postdoc (with Stephen Elledge) | Harvard Medical School (HHMI)
Genetics

Awards

2014
the 18th Annual Centers for AIDS Research (CFAR) National Meeting Junior Faculty Award
Sponsor: NIH/CFAR
Location: Providence, RI, United States

2012 - 2013
National Research Service Award (NRSA) F32 Individual Postdoctoral Fellowship Award
Sponsor: NIH/NIAID

2011
The 19th Conference on Retroviruses and Opportunistic Infections (CROI) Young Investigator Award
Location: Boston, MA, United States

2007 - 2009
American Heart Association (AHA) Predoctoral Fellowship Award
Sponsor: American Heart Association
Location: Dallas, TX, United States

2000
Undergraduate Thesis Presentation Award
Sponsor: Peking University
Location: Beijing, P.R. China

1997 - 2000
Annual University Fellowship Award for Excellent Undergraduates
Sponsor: Peking University
Location: Beijing, P.R. China

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Publications

Journal Articles

4/1/2017
Jean MJ, Power D, Kong W, Huang H, Santoso N, Zhu J. "Identification of HIV-1 Tat-Associated Proteins Contributing to HIV-1 Transcription and Latency." Viruses. 2017 Apr 1; 9(4)Epub 2017 Apr 01.

3/14/2017
Liu K, Xie F, Gao A, Zhang R, Zhang L, Xiao Z, Hu Q, Huang W, Huang Q, Lin B, Zhu J, Wang H, Que J, Lan X. "SOX2 regulates multiple malignant processes of breast cancer development through the SOX2/miR-181a-5p, miR-30e-5p/TUSC3 axis." Molecular cancer. 2017 Mar 14; 16(1):62. Epub 2017 Mar 14.

11/6/2015
Huang H, Santoso N, Power D, Simpson S, Dieringer M, Miao H, Gurova K, Giam CZ, Elledge S, Zhu J. "FACT Proteins, SUPT16H and SSRP1, Are Transcriptional Suppressors of HIV-1 and HTLV-1 That Facilitate Viral Latency." The Journal of biological chemistry.. 2015 Nov 6; 290(45):27297-310. Epub 2015 Sep 16.

Books & Chapters

2005
Chapter Title: Pluronic Block Copolymers for Drug and Gene Delivery
Book Title: Polymeric Drug Delivery Systems
Author List: Kabanov AV and Zhu J.
Edited By: G. Kwon
Published By: Informa Healthcare2005 in London, United Kingdom

2005
Chapter Title: Pluronic Block Copolymers for Gene Delivery
Book Title: Adv Genet
Author List: 1. Kabanov A, Zhu J, Alakhov V.
Published By: Elsevier Inc.2005

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