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Cheryl Ackert-Bicknell, Ph.D.

Contact Information

Phone Numbers

Office: (585) 275-1335

Biography

Research

It is currently estimated that half of all Americans over the age of 50 either already have osteoporosis or are at serious risk for the development of this disease. Low bone mass is associated with increased osteoporotic fracture risk and up to 85% of the variance in peak bone mass is heritable. Genome wide association studies (GWAS) in humans have identified a number of loci for bone mineral density (BMD);however, only a small fraction of the variance in BMD can be collectively explained by the identified loci. It has been postulated that BMD is controlled by many small effect size loci, and that much of this missing variance would be captured if these loci could be conclusively mapped. However, bone is not insulated from nor is it without consequence on the rest of an organism's physiology. It is well established that cardiovascular disease (CVD) and osteoporosis share common etiologies. Diagnosis of CVD is associated with increased risk of hip fracture, and low bone mass in women is an independent predictor of CVD. Furthermore, patient behaviors that increase risk for CVD (i.e. lack of exercise, smoking) are also risk factors for development of low bone mass. My research program has two main focuses: 1) determining the genes required for proper osteoblast development and function and 2) elucidating the impact of dietary cholesterol on these genes to impact upon osteoblast development and function.

Osteoblasts are mononuclear cells that differentiate from mesenchymal stem cells (MSCs). They function to form the protein matrix of the osteoid and to mineralize this matrix to produce healthy bone tissue. Mineralization rate and level by the osteoblast varies significantly among the inbred mouse strains, emphasizing that activity by these cells is genetically regulated. Using a variety of strategies including high-throughput RNAseq, genetic mapping and in-depth phenotyping of transgenic mouse models, I am investigating the genetic underpinnings that control osteoblast function. Low levels of HDL cholesterol and BMD are risk factors for CVD and osteoporosis respectively. It is well understood that dietary fat intake affects serum HDL cholesterol levels in certain genetic contexts, and I have shown that dietary fat can interact with certain genes to influence bone mass. Further, I have determined that genetic loci for these two phenotypes co-map with high frequency and these co-mapping loci may interact with dietary fat intake. I am using mouse models as discovery tools to better define the genetic relationship between serum HDL and BMD, and to determine how dietary fat impacts osteoblast maturation and function in the context of differing genetic backgrounds.

Credentials

Faculty Appointments

Education

1997
BSc | Canada-University of Guelph, Ontario
Molecular Biology

2000
MSc | Canada-U Western Ontario, London
Physiology

2007
PhD | University of Maine-Orono
Biochemistry and Molecular Biology

Awards

2006
Young Investigator Award, American Society of Bone and Mineral Research

2005
Chair's Fund Travel Award to Attend the Gordon Research Conference on Insulin like Growth Factors in Physiology and Disease

1998
Journal of Cell Science Traveling Fellowship

1993
Ontario Scholar

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Publications

Journal Articles

25/2017
Medina-Gomez C, Kemp JP, Dimou NL, Kreiner E, Chesi A, Zemel BS, Bønnelykke K, Boer CG, Ahluwalia TS, Bisgaard H, Evangelou E, Heppe DHM, Bonewald LF, Gorski JP, Ghanbari M, Demissie S, Duque G, Maurano MT, Kiel DP, Hsu YH, C J van der Eerden B, Ackert-Bicknell C, Reppe S, Gautvik KM, Raastad T, Karasik D, van de Peppel J, Jaddoe VWV, Uitterlinden AG, Tobias JH, Grant SFA, Bagos PG, Evans DM, Rivadeneira F. "Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1/TOM1L2 locus." Nature communications. 2017 8(1):121. Epub 2017 Jul 25.

12/2016
Nielson CM, Liu CT, Smith AV, Ackert-Bicknell CL, Reppe S, Johanna J, Wassel C, Register TC, Oei L, Alonso Lopez N, Oei EH, Parimi N, Samelson EJ, Nalls MA, Zmuda J, Lang T, Bouxsein M, Latourelle J, Claussnitzer M, Siggeirsdottir K, Srikanth P, Lorentzen E, Vandenput L, Langefeld C, Raffield L, Terry G, Cox AJ, Allison MA, Criqui MH, Bowden D, Ikram MA, Mellström D, Karlsson MK, Carr J, Budoff M, Phillips C, Cupples LA, Chou WC, Myers RH, Ralston SH, Gautvik KM, Cawthon PM, Cummings S, Karasik D, Rivadeneira F, Gudnason V, Orwoll ES, Harris TB, Ohlsson C, Kiel DP, Hsu YH. "Novel Genetic Variants Associated With Increased Vertebral Volumetric BMD, Reduced Vertebral Fracture Risk, and Increased Expression of SLC1A3 and EPHB2." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2016 Dec 0; 31(12):2085-2097. Epub 2016 Sep 06.

9/14/2016
Dyment NA, Jiang X, Chen L, Hong SH, Adams DJ, Ackert-Bicknell C, Shin DG, Rowe DW. "High-Throughput, Multi-Image Cryohistology of Mineralized Tissues." Journal of visualized experiments : JoVE.. 2016 Sep 14; (115)Epub 2016 Sep 14.

Books & Chapters

2012
Chapter Title: Development and Disease of the mouse muscular and Skeletal Systems
Book Title: The Laboratory Mouse
Author List: Sher RB, Cox GA and Ackert-Bicknell C
Published By: Elsevier Ltd2012

2004
Chapter Title: N-Acetyl Cysteine Supplementation of Growing mice: Effects on skeletal size, bone mineral density and serum IGF-I
Book Title: Nutritional Aspects of Osteoporosis
Author List: Ackert-Bicknell CL, Beamer WG, Rosen CJ
Edited By: Burckhardt P. et al
Published By: Academic Press2004

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