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Cheryl Ackert-Bicknell, Ph.D.

Publications

Showing all 55 journal articles & 2 books available

Journal Articles

7/25/2017
Medina-Gomez C, Kemp JP, Dimou NL, Kreiner E, Chesi A, Zemel BS, Bønnelykke K, Boer CG, Ahluwalia TS, Bisgaard H, Evangelou E, Heppe DHM, Bonewald LF, Gorski JP, Ghanbari M, Demissie S, Duque G, Maurano MT, Kiel DP, Hsu YH, C J van der Eerden B, Ackert-Bicknell C, Reppe S, Gautvik KM, Raastad T, Karasik D, van de Peppel J, Jaddoe VWV, Uitterlinden AG, Tobias JH, Grant SFA, Bagos PG, Evans DM, Rivadeneira F. "Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1/TOM1L2 locus." Nature communications. 2017 Jul 25; 8(1):121. Epub 2017 Jul 25.

12/2016
Nielson CM, Liu CT, Smith AV, Ackert-Bicknell CL, Reppe S, Johanna J, Wassel C, Register TC, Oei L, Alonso Lopez N, Oei EH, Parimi N, Samelson EJ, Nalls MA, Zmuda J, Lang T, Bouxsein M, Latourelle J, Claussnitzer M, Siggeirsdottir K, Srikanth P, Lorentzen E, Vandenput L, Langefeld C, Raffield L, Terry G, Cox AJ, Allison MA, Criqui MH, Bowden D, Ikram MA, Mellström D, Karlsson MK, Carr J, Budoff M, Phillips C, Cupples LA, Chou WC, Myers RH, Ralston SH, Gautvik KM, Cawthon PM, Cummings S, Karasik D, Rivadeneira F, Gudnason V, Orwoll ES, Harris TB, Ohlsson C, Kiel DP, Hsu YH. "Novel Genetic Variants Associated With Increased Vertebral Volumetric BMD, Reduced Vertebral Fracture Risk, and Increased Expression of SLC1A3 and EPHB2." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2016 Dec 0; 31(12):2085-2097. Epub 2016 Sep 06.

9/14/2016
Dyment NA, Jiang X, Chen L, Hong SH, Adams DJ, Ackert-Bicknell C, Shin DG, Rowe DW. "High-Throughput, Multi-Image Cryohistology of Mineralized Tissues." Journal of visualized experiments : JoVE.. 2016 Sep 14; (115)Epub 2016 Sep 14.

8/2016
Adams DJ, Rowe DW, Ackert-Bicknell CL. "Genetics of aging bone." Mammalian genome : official journal of the International Mammalian Genome Society.. 2016 Aug 0; 27(7-8):367-80. Epub 2016 Jun 06.

8/2016
Parker CC, Gopalakrishnan S, Carbonetto P, Gonzales NM, Leung E, Park YJ, Aryee E, Davis J, Blizard DA, Ackert-Bicknell CL, Lionikas A, Pritchard JK, Palmer AA. "Genome-wide association study of behavioral, physiological and gene expression traits in outbred CFW mice." Nature genetics.. 2016 Aug 0; 48(8):919-26. Epub 2016 Jul 04.

2/2016
Bogue MA, Peters LL, Paigen B, Korstanje R, Yuan R, Ackert-Bicknell C, Grubb SC, Churchill GA, Chesler EJ. "Accessing Data Resources in the Mouse Phenome Database for Genetic Analysis of Murine Life Span and Health Span." The journals of gerontology. Series A, Biological sciences and medical sciences.. 2016 Feb 0; 71(2):170-7. Epub 2014 Dec 22.

2/2016
Berndt A, Ackert-Bicknell C, Silva KA, Kennedy VE, Sundberg BA, Cates JM, Schofield PN, Sundberg JP. "Genetic determinants of fibro-osseous lesions in aged inbred mice." Experimental and molecular pathology.. 2016 Feb 0; 100(1):92-100. Epub 2015 Nov 14.

2/2016
Ackert-Bicknell CL, Rosen CJ. "Passenger Gene Mutations: Unwanted Guests in Genetically Modified Mice." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2016 Feb 0; 31(2):270-3. Epub 2016 Jan 19.

1/2016
Kates SL, Ackert-Bicknell CL. "How do bisphosphonates affect fracture healing?" Injury.. 2016 Jan 0; 47 Suppl 1:S65-8.

11/2015
Pallares LF, Carbonetto P, Gopalakrishnan S, Parker CC, Ackert-Bicknell CL, Palmer AA, Tautz D. "Mapping of Craniofacial Traits in Outbred Mice Identifies Major Developmental Genes Involved in Shape Determination." PLoS genetics.. 2015 Nov 0; 11(11):e1005607. Epub 2015 Nov 02.

10/1/2015
Zheng HF, Forgetta V, Hsu YH, Estrada K, Rosello-Diez A, Leo PJ, Dahia CL, Park-Min KH, Tobias JH, Kooperberg C, Kleinman A, Styrkarsdottir U, Liu CT, Uggla C, Evans DS, Nielson CM, Walter K, Pettersson-Kymmer U, McCarthy S, Eriksson J, Kwan T, Jhamai M, Trajanoska K, Memari Y, Min J, Huang J, Danecek P, Wilmot B, Li R, Chou WC, Mokry LE, Moayyeri A, Claussnitzer M, Cheng CH, Cheung W, Medina-Gómez C, Ge B, Chen SH, Choi K, Oei L, Fraser J, Kraaij R, Hibbs MA, Gregson CL, Paquette D, Hofman A, Wibom C, Tranah GJ, Marshall M, Gardiner BB, Cremin K, Auer P, Hsu L, Ring S, Tung JY, Thorleifsson G, Enneman AW, van Schoor NM, de Groot LC, van der Velde N, Melin B, Kemp JP, Christiansen C, Sayers A, Zhou Y, Calderari S, van Rooij J, Carlson C, Peters U, Berlivet S, Dostie J, Uitterlinden AG, Williams SR, Farber C, Grinberg D, LaCroix AZ, Haessler J, Chasman DI, Giulianini F, Rose LM, Ridker PM, Eisman JA, Nguyen TV, Center JR, Nogues X, Garcia-Giralt N, Launer LL, Gudnason V, Mellström D, Vandenput L, Amin N, van Duijn CM, Karlsson MK, Ljunggren Ö, Svensson O, Hallmans G, Rousseau F, Giroux S, Bussière J, Arp PP, Koromani F, Prince RL, Lewis JR, Langdahl BL, Pernille Hermann A, Jensen JB, Kaptoge S, Khaw KT, Reeve J, Formosa MM, Xuereb-Anastasi A, Åkesson K, McGuigan FE, Garg G, Olmos JM, Zarrabeitia MT, Riancho JA, Ralston SH, Alonso N, Jiang X, Goltzman D, Pastinen T, Grundberg E, Gauguier D, Orwoll ES, Karasik D, Davey-Smith G, , Smith AV, Siggeirsdottir K, Harris TB, Carola Zillikens M, van Meurs JB, Thorsteinsdottir U, Maurano MT, Timpson NJ, Soranzo N, Durbin R, Wilson SG, Ntzani EE, Brown MA, Stefansson K, Hinds DA, Spector T, Adrienne Cupples L, Ohlsson C, Greenwood CM, , Jackson RD, Rowe DW, Loomis CA, Evans DM, Ackert-Bicknell CL, Joyner AL, Duncan EL, Kiel DP, Rivadeneira F, Richards JB. "Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture." Nature.. 2015 Oct 1; 526(7571):112-7. Epub 2015 Sep 14.

7/2015
Hagiwara Y, Dyment NA, Jiang X, Huang J, Ackert-Bicknell C, Adams DJ, Rowe DW. "Fixation stability dictates the differentiation pathway of periosteal progenitor cells in fracture repair." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2015 Jul 0; 33(7):948-56. Epub 2015 May 13.

6/1/2015
Ackert-Bicknell CL, Anderson LC, Sheehan S, Hill WG, Chang B, Churchill GA, Chesler EJ, Korstanje R, Peters LL. "Aging Research Using Mouse Models." Current protocols in mouse biology. 2015 Jun 1; 5(2):95-133. Epub 2015 Jun 01.

2015
Adams DJ, Ackert-Bicknell CL. "Genetic regulation of bone strength: a review of animal model studies." BoneKEy reports. 2015 4:714. Epub 2015 Jul 08.

6/1/2014
Yu W, Ackert-Bicknell C, Larigakis JD, MacIver B, Steers WD, Churchill GA, Hill WG, Zeidel ML. "Spontaneous voiding by mice reveals strain-specific lower urinary tract function to be a quantitative genetic trait." American journal of physiology. Renal physiology.. 2014 Jun 1; 306(11):F1296-307. Epub 2014 Apr 09.

6/2014
Kemp JP, Medina-Gomez C, Estrada K, St Pourcain B, Heppe DH, Warrington NM, Oei L, Ring SM, Kruithof CJ, Timpson NJ, Wolber LE, Reppe S, Gautvik K, Grundberg E, Ge B, van der Eerden B, van de Peppel J, Hibbs MA, Ackert-Bicknell CL, Choi K, Koller DL, Econs MJ, Williams FM, Foroud T, Zillikens MC, Ohlsson C, Hofman A, Uitterlinden AG, Davey Smith G, Jaddoe VW, Tobias JH, Rivadeneira F, Evans DM. "Phenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment." PLoS genetics.. 2014 Jun 0; 10(6):e1004423. Epub 2014 Jun 19.

9/2013
Ackert-Bicknell CL, Karasik D. "Impact of the environment on the skeleton: is it modulated by genetic factors?" Current osteoporosis reports.. 2013 Sep 0; 11(3):219-28.

8/2013
Hochrath K, Ehnert S, Ackert-Bicknell CL, Lau Y, Schmid A, Krawczyk M, Hengstler JG, Dunn J, Hiththetiya K, Rathkolb B, Micklich K, Hans W, Fuchs H, Gailus-Durner V, Wolf E, de Angelis MH, Dooley S, Paigen B, Wildemann B, Lammert F, Nüssler AK. "Modeling hepatic osteodystrophy in Abcb4 deficient mice." Bone.. 2013 Aug 0; 55(2):501-11. Epub 2013 Mar 29.

4/2013
Ackert-Bicknell C, Paigen B, Korstanje R. "Recalculation of 23 mouse HDL QTL datasets improves accuracy and allows for better candidate gene analysis." Journal of lipid research.. 2013 Apr 0; 54(4):984-94. Epub 2013 Feb 07.

5/2012
Ackert-Bicknell CL, Demissie S, Tsaih SW, Beamer WG, Cupples LA, Paigen BJ, Hsu YH, Kiel DP, Karasik D. "Genetic variation in TRPS1 may regulate hip geometry as well as bone mineral density." Bone.. 2012 May 0; 50(5):1188-95. Epub 2012 Jan 28.

2/2012
Ackert-Bicknell CL. "HDL cholesterol and bone mineral density: is there a genetic link?" Bone.. 2012 Feb 0; 50(2):525-33.

2012
Gu T, Buaas FW, Simons AK, Ackert-Bicknell CL, Braun RE, Hibbs MA. "Canonical A-to-I and C-to-U RNA editing is enriched at 3'UTRs and microRNA target sites in multiple mouse tissues." PloS one. 2012 7(3):e33720. Epub 2012 Mar 20.

2012
Ackert-Bicknell CL, Hibbs MA. "The need for mouse models in osteoporosis genetics research." BoneKEy reports. 2012 1:98. Epub 2012 Jun 13.

8/2011
Philip VM, Sokoloff G, Ackert-Bicknell CL, Striz M, Branstetter L, Beckmann MA, Spence JS, Jackson BL, Galloway LD, Barker P, Wymore AM, Hunsicker PR, Durtschi DC, Shaw GS, Shinpock S, Manly KF, Miller DR, Donohue KD, Culiat CT, Churchill GA, Lariviere WR, Palmer AA, O'Hara BF, Voy BH, Chesler EJ. "Genetic analysis in the Collaborative Cross breeding population." Genome research.. 2011 Aug 0; 21(8):1223-38. Epub 2011 Jul 06.

1/2011
Beamer WG, Shultz KL, Coombs HF, DeMambro VE, Reinholdt LG, Ackert-Bicknell CL, Canalis E, Rosen CJ, Donahue LR. "BMD regulation on mouse distal chromosome 1, candidate genes, and response to ovariectomy or dietary fat." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2011 Jan 0; 26(1):88-99.

11/11/2010
Guan Y, Ackert-Bicknell CL, Kell B, Troyanskaya OG, Hibbs MA. "Functional genomics complements quantitative genetics in identifying disease-gene associations." PLoS computational biology.. 2010 Nov 11; 6(11):e1000991. Epub 2010 Nov 11.

8/2010
Ackert-Bicknell CL, Karasik D, Li Q, Smith RV, Hsu YH, Churchill GA, Paigen BJ, Tsaih SW. "Mouse BMD quantitative trait loci show improved concordance with human genome-wide association loci when recalculated on a new, common mouse genetic map." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2010 Aug 0; 25(8):1808-20.

6/8/2010
Kawai M, Green CB, Lecka-Czernik B, Douris N, Gilbert MR, Kojima S, Ackert-Bicknell C, Garg N, Horowitz MC, Adamo ML, Clemmons DR, Rosen CJ. "A circadian-regulated gene, Nocturnin, promotes adipogenesis by stimulating PPAR-gamma nuclear translocation." Proceedings of the National Academy of Sciences of the United States of America.. 2010 Jun 8; 107(23):10508-13. Epub 2010 May 24.

3/2010
Kawai M, Green CB, Horowitz M, Ackert-Bicknell C, Lecka-Czernik B, Rosen CJ. "Nocturnin: a circadian target of Pparg-induced adipogenesis." Annals of the New York Academy of Sciences.. 2010 Mar 0; 1192:131-8.

8/2009
Cox A, Ackert-Bicknell CL, Dumont BL, Ding Y, Bell JT, Brockmann GA, Wergedal JE, Bult C, Paigen B, Flint J, Tsaih SW, Churchill GA, Broman KW. "A new standard genetic map for the laboratory mouse." Genetics.. 2009 Aug 0; 182(4):1335-44. Epub 2009 Jun 17.

3/2009
Ackert-Bicknell CL, Shockley KR, Horton LG, Lecka-Czernik B, Churchill GA, Rosen CJ. "Strain-specific effects of rosiglitazone on bone mass, body composition, and serum insulin-like growth factor-I." Endocrinology.. 2009 Mar 0; 150(3):1330-40. Epub 2008 Oct 23.

2009
Rosen CJ, Ackert-Bicknell C, Rodriguez JP, Pino AM. "Marrow fat and the bone microenvironment: developmental, functional, and pathological implications." Critical reviews in eukaryotic gene expression.. 2009 19(2):109-24.

9/2008
Ackert-Bicknell CL, Demissie S, Marín de Evsikova C, Hsu YH, DeMambro VE, Karasik D, Cupples LA, Ordovas JM, Tucker KL, Cho K, Canalis E, Paigen B, Churchill GA, Forejt J, Beamer WG, Ferrari S, Bouxsein ML, Kiel DP, Rosen CJ. "PPARG by dietary fat interaction influences bone mass in mice and humans." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2008 Sep 0; 23(9):1398-408.

11/2007
Ackert-Bicknell CL, Salisbury JL, Horowitz M, DeMambro VE, Horton LG, Shultz KL, Lecka-Czernik B, Rosen CJ. "A chromosomal inversion within a quantitative trait locus has a major effect on adipogenesis and osteoblastogenesis." Annals of the New York Academy of Sciences.. 2007 Nov 0; 1116:291-305. Epub 2007 Jun 21.

8/2007
Beamer WG, Shultz KL, Ackert-Bicknell CL, Horton LG, Delahunty KM, Coombs HF, Donahue LR, Canalis E, Rosen CJ. "Genetic dissection of mouse distal chromosome 1 reveals three linked BMD QTLs with sex-dependent regulation of bone phenotypes." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2007 Aug 0; 22(8):1187-96.

8/2007
Wergedal JE, Ackert-Bicknell CL, Beamer WG, Mohan S, Baylink DJ, Srivastava AK. "Mapping genetic loci that regulate lipid levels in a NZB/B1NJxRF/J intercross and a combined intercross involving NZB/B1NJ, RF/J, MRL/MpJ, and SJL/J mouse strains." Journal of lipid research.. 2007 Aug 0; 48(8):1724-34. Epub 2007 May 13.

2/2007
Lecka-Czernik B, Ackert-Bicknell C, Adamo ML, Marmolejos V, Churchill GA, Shockley KR, Reid IR, Grey A, Rosen CJ. "Activation of peroxisome proliferator-activated receptor gamma (PPARgamma) by rosiglitazone suppresses components of the insulin-like growth factor regulatory system in vitro and in vivo." Endocrinology.. 2007 Feb 0; 148(2):903-11. Epub 2006 Nov 22.

8/2006
Delahunty KM, Shultz KL, Gronowicz GA, Koczon-Jaremko B, Adamo ML, Horton LG, Lorenzo J, Donahue LR, Ackert-Bicknell C, Kream BE, Beamer WG, Rosen CJ. "Congenic mice provide in vivo evidence for a genetic locus that modulates serum insulin-like growth factor-I and bone acquisition." Endocrinology.. 2006 Aug 0; 147(8):3915-23. Epub 2006 May 04.

8/2006
Wergedal JE, Ackert-Bicknell CL, Tsaih SW, Sheng MH, Li R, Mohan S, Beamer WG, Churchill GA, Baylink DJ. "Femur mechanical properties in the F2 progeny of an NZB/B1NJ x RF/J cross are regulated predominantly by genetic loci that regulate bone geometry." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2006 Aug 0; 21(8):1256-66.

6/2006
Adamo ML, Ma X, Ackert-Bicknell CL, Donahue LR, Beamer WG, Rosen CJ. "Genetic increase in serum insulin-like growth factor-I (IGF-I) in C3H/HeJ compared with C57BL/6J mice is associated with increased transcription from the IGF-I exon 2 promoter." Endocrinology.. 2006 Jun 0; 147(6):2944-55. Epub 2006 Mar 09.

2/2006
Akeson EC, Donahue LR, Beamer WG, Shultz KL, Ackert-Bicknell C, Rosen CJ, Corrigan J, Davisson MT. "Chromosomal inversion discovered in C3H/HeJ mice." Genomics.. 2006 Feb 0; 87(2):311-3. Epub 2005 Nov 23.

1/2006
Mikaelian I, Hovick M, Silva KA, Burzenski LM, Shultz LD, Ackert-Bicknell CL, Cox GA, Sundberg JP. "Expression of terminal differentiation proteins defines stages of mouse mammary gland development." Veterinary pathology.. 2006 Jan 0; 43(1):36-49.

2006
Ackert-Bicknell C, Rosen C. "The Genetics of PPARG and the Skeleton." PPAR research. 2006 2006:93258.

9/2005
Iida K, Rosen CJ, Ackert-Bicknell C, Thorner MO. "Genetic differences in the IGF-I gene among inbred strains of mice with different serum IGF-I levels." The Journal of endocrinology.. 2005 Sep 0; 186(3):481-9.

3/2005
Rosen CJ, Ackert-Bicknell C, Beamer WG, Nelson T, Adamo M, Cohen P, Bouxsein ML, Horowitz MC. "Allelic differences in a quantitative trait locus affecting insulin-like growth factor-I impact skeletal acquisition and body composition." Pediatric nephrology : journal of the International Pediatric Nephrology Association.. 2005 Mar 0; 20(3):255-60. Epub 2004 Nov 10.

1/2005
Wergedal JE, Sheng MH, Ackert-Bicknell CL, Beamer WG, Baylink DJ. "Genetic variation in femur extrinsic strength in 29 different inbred strains of mice is dependent on variations in femur cross-sectional geometry and bone density." Bone.. 2005 Jan 0; 36(1):111-22. Epub 2004 Nov 24.

11/2004
Rosen CJ, Ackert-Bicknell CL, Adamo ML, Shultz KL, Rubin J, Donahue LR, Horton LG, Delahunty KM, Beamer WG, Sipos J, Clemmons D, Nelson T, Bouxsein ML, Horowitz M. "Congenic mice with low serum IGF-I have increased body fat, reduced bone mineral density, and an altered osteoblast differentiation program." Bone.. 2004 Nov 0; 35(5):1046-58.

2/2004
Fan X, Roy E, Zhu L, Murphy TC, Ackert-Bicknell C, Hart CM, Rosen C, Nanes MS, Rubin J. "Nitric oxide regulates receptor activator of nuclear factor-kappaB ligand and osteoprotegerin expression in bone marrow stromal cells." Endocrinology.. 2004 Feb 0; 145(2):751-9. Epub 2003 Oct 16.

12/1/2003
Dorward AM, Shultz KL, Ackert-Bicknell CL, Eicher EM, Beamer WG. "High-resolution genetic map of X-linked juvenile-type granulosa cell tumor susceptibility genes in mouse." Cancer research.. 2003 Dec 1; 63(23):8197-202.

12/2002
Wergedal JE, Sheng MH, Ackert-Bicknell CL, Beamer WG, Baylink DJ. "Mouse genetic model for bone strength and size phenotypes: NZB/B1NJ and RF/J inbred strains." Bone.. 2002 Dec 0; 31(6):670-4.

9/2002
Rubin J, Ackert-Bicknell CL, Zhu L, Fan X, Murphy TC, Nanes MS, Marcus R, Holloway L, Beamer WG, Rosen CJ. "IGF-I regulates osteoprotegerin (OPG) and receptor activator of nuclear factor-kappaB ligand in vitro and OPG in vivo." The Journal of clinical endocrinology and metabolism.. 2002 Sep 0; 87(9):4273-9.

9/2002
Yakar S, Rosen CJ, Beamer WG, Ackert-Bicknell CL, Wu Y, Liu JL, Ooi GT, Setser J, Frystyk J, Boisclair YR, LeRoith D. "Circulating levels of IGF-1 directly regulate bone growth and density." The Journal of clinical investigation.. 2002 Sep 0; 110(6):771-81.

4/2002
Bouxsein ML, Rosen CJ, Turner CH, Ackert CL, Shultz KL, Donahue LR, Churchill G, Adamo ML, Powell DR, Turner RT, Muller R, Beamer WG. "Generation of a new congenic mouse strain to test the relationships among serum insulin-like growth factor I, bone mineral density, and skeletal morphology in vivo." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2002 Apr 0; 17(4):570-9.

5/15/2001
Ackert CL, Gittens JE, O'Brien MJ, Eppig JJ, Kidder GM. "Intercellular communication via connexin43 gap junctions is required for ovarian folliculogenesis in the mouse." Developmental biology.. 2001 May 15; 233(2):258-70.

10/2000
Rosen CJ, Churchill GA, Donahue LR, Shultz KL, Burgess JK, Powell DR, Ackert C, Beamer WG. "Mapping quantitative trait loci for serum insulin-like growth factor-1 levels in mice." Bone.. 2000 Oct 0; 27(4):521-8.

Books & Chapters

2012
Chapter Title: Development and Disease of the mouse muscular and Skeletal Systems
Book Title: The Laboratory Mouse
Author List: Sher RB, Cox GA and Ackert-Bicknell C
Published By: Elsevier Ltd2012

2004
Chapter Title: N-Acetyl Cysteine Supplementation of Growing mice: Effects on skeletal size, bone mineral density and serum IGF-I
Book Title: Nutritional Aspects of Osteoporosis
Author List: Ackert-Bicknell CL, Beamer WG, Rosen CJ
Edited By: Burckhardt P. et al
Published By: Academic Press2004