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Sarah L. Kerns, Ph.D., M.P.H.

Contact Information

Phone Numbers

Office: (585) 275-2229

Biography

Research

My research focus is on an area termed 'Radiogenomics', which is the study of genetic factors that are associated with increased risk of developing late effects from radiotherapy used in treatment of cancer. The long term goal of this work is to develop a single nucleotide polymorphism (SNP) - based signature that can identify individual cancer patients who are at high risk of developing various normal tissue effects from their radiation treatment. Several genome-wide association studies are underway among prostate cancer cohorts in which patients are treated with radiotherapy and followed-up for several years to monitor for development of late urinary, rectal and sexual effects. The goal of these studies is to identify SNPs associated with each of these types of late radiotherapy effects and then develop risk models using these SNPs. Such models could be incorporated into clinical trials aiming to personalize radiotherapy to an individual's risk of normal tissue effects.

Credentials

Faculty Appointments

Education

2002
BS | University of Wisconsin-Madison
Biochemistry

2007
PhD | Northwestern University The Feinberg School of Medicine
Cancer Biology

2008
MPH | Johns Hopkins Bloomberg School of Public Health
Public Health

Awards

2017 - 2019
NCI Clinical Loan Repayment Program Award
Sponsor: NIH/NCI

2015 - 2020
NCI K07 Career Development Award
Sponsor: NIH/NCI

2010
Annual Meeting Award
Sponsor: American Society for Radiation Oncology (ASTRO)

2008
MPH Field Experience Fund-Group Award
Sponsor: Johns Hopkins Bloomberg School of Public Health

2004 - 2005
Chicago Baseball Cancer Charities Fellowship
Sponsor: Northwestern Univ. Robert H. Lurie Comprehensive Cancer Center

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Publications

Journal Articles

8/1/2017
El Naqa I, Kerns SL, Coates J, Luo Y, Speers C, West CML, Rosenstein BS, Ten Haken RK. "Radiogenomics and radiotherapy response modeling." Physics in medicine and biology.. 2017 Aug 1; 62(16):R179-R206. Epub 2017 Aug 01.

4/10/2017
Fung C, Sesso HD, Williams AM, Kerns SL, Monahan P, Abu Zaid M, Feldman DR, Hamilton RJ, Vaughn DJ, Beard CJ, Kollmannsberger CK, Cook R, Althouse S, Ardeshir-Rouhani-Fard S, Lipshultz SE, Einhorn LH, Fossa SD, Travis LB, . "Multi-Institutional Assessment of Adverse Health Outcomes Among North American Testicular Cancer Survivors After Modern Cisplatin-Based Chemotherapy." Journal of clinical oncology : official journal of the American Society of Clinical Oncology.. 2017 Apr 10; 35(11):1211-1222. Epub 2017 Feb 27.

2/24/2017
Oh JH, Kerns S, Ostrer H, Powell SN, Rosenstein B, Deasy JO. "Computational methods using genome-wide association studies to predict radiotherapy complications and to identify correlative molecular processes." Scientific reports.. 2017 Feb 24; 7:43381. Epub 2017 Feb 24.

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