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Sarah L. Kerns, Ph.D., M.P.H.

Contact Information

Phone Numbers

Office: (585) 275-2229

Faculty Appointments

Biography

Research

My research focus is on an area termed 'Radiogenomics', which is the study of genetic factors that are associated with increased risk of developing late effects from radiotherapy used in treatment of cancer. The long term goal of this work is to develop a single nucleotide polymorphism (SNP) - based signature that can identify individual cancer patients who are at high risk of developing various normal tissue effects from their radiation treatment. Several genome-wide association studies are underway among prostate cancer cohorts in which patients are treated with radiotherapy and followed-up for several years to monitor for development of late urinary, rectal and sexual effects. The goal of these studies is to identify SNPs associated with each of these types of late radiotherapy effects and then develop risk models using these SNPs. Such models could be incorporated into clinical trials aiming to personalize radiotherapy to an individual's risk of normal tissue effects.

Credentials

Education

2002
BS | University of Wisconsin-Madison
Biochemistry

2007
PhD | Northwestern University The Feinberg School of Medicine
Cancer Biology

2008
MPH | Johns Hopkins Bloomberg School of Public Health
Public Health

Post-doctoral Training & Residency

07/2011 - 09/2013
Postdoctoral Fellow, Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, NY

07/2009 - 07/2011
Postdoctoral Fellow, Human Genetics Program, New York University Langone Medical Center, New York, NY

Awards

2017 - 2019
NCI Clinical Loan Repayment Program Award
Sponsor: NIH/NCI

2015 - 2020
NCI K07 Career Development Award
Sponsor: NIH/NCI

2010
Annual Meeting Award
Sponsor: American Society for Radiation Oncology (ASTRO)

2008
MPH Field Experience Fund-Group Award
Sponsor: Johns Hopkins Bloomberg School of Public Health

2004 - 2005
Chicago Baseball Cancer Charities Fellowship
Sponsor: Northwestern Univ. Robert H. Lurie Comprehensive Cancer Center

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Publications

Journal Articles

5/1/2018
Lee S, Kerns S, Ostrer H, Rosenstein B, Deasy JO, Oh JH. "Machine Learning on a Genome-wide Association Study to Predict Late Genitourinary Toxicity After Prostate Radiation Therapy." International journal of radiation oncology, biology, physics.. 2018 May 1; 101(1):128-135. Epub 2018 Jan 31.

4/4/2018
Kerns SL, Fung C, Monahan PO, Ardeshir-Rouhani-Fard S, Abu Zaid MI, Williams AM, Stump TE, Sesso HD, Feldman DR, Hamilton RJ, Vaughn DJ, Beard C, Huddart RA, Kim J, Kollmannsberger C, Sahasrabudhe DM, Cook R, Fossa SD, Einhorn LH, Travis LB, . "Cumulative Burden of Morbidity Among Testicular Cancer Survivors After Standard Cisplatin-Based Chemotherapy: A Multi-Institutional Study." Journal of clinical oncology : official journal of the American Society of Clinical Oncology.. 2018 Apr 4; :JCO2017770735. Epub 2018 Apr 04.

8/1/2017
El Naqa I, Kerns SL, Coates J, Luo Y, Speers C, West CML, Rosenstein BS, Ten Haken RK. "Radiogenomics and radiotherapy response modeling." Physics in medicine and biology.. 2017 Aug 1; 62(16):R179-R206. Epub 2017 Aug 01.

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