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Tingting Yang, Ph.D.


Showing all 14 journal articles & 0 books available

Journal Articles

Ji C, Kittredge A, Hopiavuori A, Ward N, Chen S, Fukuda Y, Zhang Y, Yang T. "Dual Ca-dependent gates in human Bestrophin1 underlie disease-causing mechanisms of gain-of-function mutations." Communications biology.. 2019 2:240. Epub 2019 Jun 24.

Kittredge A, Ji C, Zhang Y, Yang T. "Differentiation, Maintenance, and Analysis of Human Retinal Pigment Epithelium Cells: A Disease-in-a-dish Model for BEST1 Mutations." Journal of visualized experiments : JoVE.. 2018 Aug 24; (138)Epub 2018 Aug 24.

Zhang Y, Kittredge A, Ward N, Ji C, Chen S, Yang T. "ATP activates bestrophin ion channels through direct interaction." Nature communications.. 2018 Aug 7; 9(1):3126. Epub 2018 Aug 07.

Kittredge A, Ward N, Hopiavuori A, Zhang Y, Yang T. "Expression and Purification of Mammalian Bestrophin Ion Channels." Journal of visualized experiments : JoVE.. 2018 Aug 2; (138)Epub 2018 Aug 02.

Li Y, Zhang Y, Xu Y, Kittredge A, Ward N, Chen S, Tsang SH, Yang T. "Patient-specific mutations impair BESTROPHIN1's essential role in mediating Ca-dependent Cl currents in human RPE." eLife.. 2017 Oct 24; 6Epub 2017 Oct 24.

Yang T, Colecraft HM. "Calmodulin regulation of TMEM16A and 16B Ca(2+)-activated chloride channels." Channels.. 2016 10(1):38-44. Epub 2015 Jun 17.

Yang T, Justus S, Li Y, Tsang SH. "BEST1: the Best Target for Gene and Cell Therapies." Molecular therapy : the journal of the American Society of Gene Therapy.. 2015 Dec 0; 23(12):1805-9. Epub 2015 Sep 21.

Yang T, Hendrickson WA, Colecraft HM. "Preassociated apocalmodulin mediates Ca2+-dependent sensitization of activation and inactivation of TMEM16A/16B Ca2+-gated Cl- channels." Proceedings of the National Academy of Sciences of the United States of America.. 2014 Dec 23; 111(51):18213-8. Epub 2014 Dec 08.

Yang T, Liu Q, Kloss B, Bruni R, Kalathur RC, Guo Y, Kloppmann E, Rost B, Colecraft HM, Hendrickson WA. "Structure and selectivity in bestrophin ion channels." Science.. 2014 Oct 17; 346(6207):355-9. Epub 2014 Sep 25.

Yang T, Colecraft HM. "Regulation of voltage-dependent calcium channels by RGK proteins." Biochimica et biophysica acta.. 2013 Jul 0; 1828(7):1644-54. Epub 2012 Oct 10.

Yang T, He LL, Chen M, Fang K, Colecraft HM. "Bio-inspired voltage-dependent calcium channel blockers." Nature communications.. 2013 4:2540.

Yang T, Puckerin A, Colecraft HM. "Distinct RGK GTPases differentially use ?1- and auxiliary ?-binding-dependent mechanisms to inhibit CaV1.2/CaV2.2 channels." PloS one.. 2012 7(5):e37079. Epub 2012 May 10.

Yang T, Xu X, Kernan T, Wu V, Colecraft HM. "Rem, a member of the RGK GTPases, inhibits recombinant CaV1.2 channels using multiple mechanisms that require distinct conformations of the GTPase." The Journal of physiology.. 2010 May 15; 588(Pt 10):1665-81. Epub 2010 Mar 22.

Yang T, Suhail Y, Dalton S, Kernan T, Colecraft HM. "Genetically encoded molecules for inducibly inactivating CaV channels." Nature chemical biology.. 2007 Dec 0; 3(12):795-804. Epub 2007 Oct 21.