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Andrew N. McDavid, Ph.D.

Andrew N. McDavid, Ph.D.

Contact

Office (585) 275-5983

Research Lab

Link to professional webpage

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About Me

Professional Background

I received my PhD in Statistics in June, 2016 from the University of Washington. From 2006-2011, I worked as a systems analyst in a genomics lab at Fred Hutchinson Cancer Research Center, where I experienced the dawn and sunset of array-based genome-wide association studies. Until I came to Roches...
I received my PhD in Statistics in June, 2016 from the University of Washington. From 2006-2011, I worked as a systems analyst in a genomics lab at Fred Hutchinson Cancer Research Center, where I experienced the dawn and sunset of array-based genome-wide association studies. Until I came to Rochester, I had only known the west coast, growing up in the suburbs of Seattle, then attending Pomona College in southern California to receive my BA in mathematics in 2006.

Faculty Appointments

Adjunct Assistant Professor - Department of Biostatistics and Computational Biology (SMD)

Research

I am interested in methods and applications of single cell gene expression assays. There is great hope, for good reason, that measuring expression profiles in single cells will aid in immunological and cancer research, and provide new insight in cellular biology (though it still only provides a cros...
I am interested in methods and applications of single cell gene expression assays. There is great hope, for good reason, that measuring expression profiles in single cells will aid in immunological and cancer research, and provide new insight in cellular biology (though it still only provides a cross-sectional sample of cells at various points in their lifespan and cell cycle.) However, the biochemical, computational and statistical challenges are sizable.

I am focusing on the combinations of all three. Through the use of unique molecular identifiers, it may be possible to better understand the biases and sources of variability current protocols introduce. I write R software to allow easier manipulation of single-cell data sets (which are sometimes almost as "tall" as they are "wide"). I develop statistical methods that accommodate the bimodality of single cell data, which yield more sensitive and better calibrated tests.

Statistical questions I am currently interested in include:
Graphical modeling and gene-gene interaction networks
Clustering and distance measures for zero-inflated data
Gene-enrichment analysis
Borrowing strength and regularizing vector generalized linear models through empirical Bayes' procedures
2nd-order univariate phenomena, such as exceptional stability or heterogeneity of expression (and how this can be identified given differing levels of technical variability).

Publications

Journal Articles

Targeting synovial lymphatic function as a novel therapeutic intervention for age-related osteoarthritis in mice.

Lin X, Bell RD, Catheline SE, Takano T, McDavid A, Jonason JH, Schwarz EM, Xing L

Arthritis & rheumatology.. 2023 January 10 Epub 01/10/2023.

Molecular signatures distinguish senescent cells from inflammatory cells in aged mouse callus stromal cells.

Liu J, Lin X, McDavid A, Yang Y, Zhang H, Boyce BF, Xing L

Frontiers in endocrinology.. 2023 14 :1090049. Epub 02/16/2023.

Granzyme K CD8 T cells form a core population in inflamed human tissue.

Jonsson AH, Zhang F, Dunlap G, Gomez-Rivas E, Watts GFM, Faust HJ, Rupani KV, Mears JR, Meednu N, Wang R, Keras G, Coblyn JS, Massarotti EM, Todd DJ, Anolik JH, McDavid A, , Wei K, Rao DA, Raychaudhuri S, Brenner MB

Science translational medicine.. 2022 June 1514 (649):eabo0686. Epub 06/15/2022.

Dynamic spectrum of ectopic lymphoid B cell activation and hypermutation in the RA synovium characterized by NR4A nuclear receptor expression.

Meednu N, Rangel-Moreno J, Zhang F, Escalera-Rivera K, Corsiero E, Prediletto E, DiCarlo E, Goodman S, Donlin LT, Raychauduri S, Bombardieri M, Pitzalis C, Orange DE, , McDavid A, Anolik JH

Cell reports.. 2022 May 339 (5):110766. Epub 1900 01 01.

Aberrant newborn T cell and microbiota developmental trajectories predict respiratory compromise during infancy.

McDavid A, Laniewski N, Grier A, Gill AL, Kessler HA, Huyck H, Carbonell E, Holden-Wiltse J, Bandyopadhyay S, Carnahan J, Dylag AM, Topham DJ, Falsey AR, Caserta MT, Pryhuber GS, Gill SR, Scheible KM

iScience.. 2022 April 1525 (4):104007. Epub 03/01/2022.

Neonatal Hyperoxia Activates ATF4 to Stimulate Folate Metabolism and AT2 Cell Proliferation.

Yee M, McDavid AN, Cohen ED, Huyck HL, Poole C, Altman BJ, Maniscalco WM, Deutsch GH, Pryhuber GS, O'Reilly MA

American journal of respiratory cell and molecular biology.. 2022 January 19 Epub 01/19/2022.

The Complex Relationship Between Cooling Parameters and Neuroprotection in a Model of Selective Hypothermia.

Mattingly TK, McDavid A, Wolf A, Lieber G, Solar R, Lee D, Lownie SP

Frontiers in neurology. 2022 13 :874701. Epub 04/25/2022.

B Cell Activation and Plasma Cell Differentiation Are Promoted by IFN-? in Systemic Lupus Erythematosus.

Barnas JL, Albrecht J, Meednu N, Alzamareh DF, Baker C, McDavid A, Looney RJ, Anolik JH

The Journal of immunology : official journal of the American Association of Immunologists.. 2021 October 27 Epub 10/27/2021.

The E3 ubiquitin ligase Itch limits the progression of post-traumatic osteoarthritis in mice by inhibiting macrophage polarization.

Lin X, Wang W, McDavid A, Xu H, Boyce BF, Xing L

Osteoarthritis and cartilage. 2021 April 30 Epub 04/30/2021.

"If the glove fits": Hospital-wide universal gloving is associated with improved hand hygiene and may reduce infection.

Prasad P, Brown L, Ma S, McDavid A, Rudmann A, Lent D, Reagan-Webster P, Valcin EK, Graman P, Apostolakos M

Infection control and hospital epidemiology.. 2021 April 23 :1-5. Epub 04/23/2021.

Neonatal hyperoxia inhibits proliferation and survival of atrial cardiomyocytes by suppressing fatty acid synthesis.

Cohen ED, Yee M, Porter GA, Ritzer EE, McDavid AN, Brookes PS, Pryhuber GS, O'Reilly MA

JCI insight.. 2021 January 28 Epub 01/28/2021.

Eight practices for data management to enable team data science.

McDavid A, Corbett AM, Dutra JL, Straw AG, Topham DJ, Pryhuber GS, Caserta MT, Gill SR, Scheible KM, Holden-Wiltse J

Journal of clinical and translational science.. 2020 June 235 (1):e14. Epub 06/23/2020.

IFN signaling inhibits osteogenesis in human SLE bone marrow.

Gao L, Liesveld J, Anolik J, Mcdavid A, Looney RJ

Lupus.. 2020 June 9 :961203320930088. Epub 06/09/2020.

Intrinsic mitotic activity supports the human salivary gland acinar cell population.

Ingalls MH, Hollomon AJ, Newlands SD, McDavid AN, Ovitt CE

FEBS letters.. 2019 September 20 Epub 09/20/2019.

Measuring the Severity of Respiratory Illness in the First 2 Years of Life in Preterm and Term Infants.

Caserta MT, Yang H, Bandyopadhyay S, Qiu X, Gill SR, Java J, McDavid A, Falsey AR, Topham DJ, Holden-Wiltse J, Scheible K, Pryhuber G

The Journal of pediatrics.. 2019 July 31 Epub 07/31/2019.

GRAPHICAL MODELS FOR ZERO-INFLATED SINGLE CELL GENE EXPRESSION.

McDavid A, Gottardo R, Simon N, Drton M

The annals of applied statistics.. 2019 June 13 (2):848-873. Epub 06/17/2019.

Bone marrow mesenchymal stem cells from patients with SLE maintain an interferon signature during in vitro culture.

Gao L, OConnell M, Allen M, Liesveld J, McDavid A, Anolik JH, Looney RJ

Cytokine.. 2019 May 29 :154725. Epub 05/29/2019.

Aged marrow macrophages expand platelet-biased hematopoietic stem cells via Interleukin1B.

Frisch BJ, Hoffman CM, Latchney SE, LaMere MW, Myers J, Ashton J, Li AJ, Saunders J, Palis J, Perkins AS, McCabe A, Smith JN, McGrath KE, Rivera-Escalera F, McDavid A, Liesveld JL, Korshunov VA, Elliott MR, MacNamara KC, Becker MW, Calvi LM

JCI insight.. 2019 April 185 Epub 04/18/2019.

Cell Senescence in Lupus.

Gao L, Slack M, McDavid A, Anolik J, Looney RJ

Current rheumatology reports.. 2019 January 1421 (2):1. Epub 01/14/2019.

T Cell-Dependent Affinity Maturation and Innate Immune Pathways Differentially Drive Autoreactive B Cell Responses in Rheumatoid Arthritis.

Lu DR, McDavid AN, Kongpachith S, Lingampalli N, Glanville J, Ju CH, Gottardo R, Robinson WH

Arthritis & rheumatology.. 2018 November 70 (11):1732-1744. Epub 09/24/2018.

Neonatal gut and respiratory microbiota: coordinated development through time and space.

Grier A, McDavid A, Wang B, Qiu X, Java J, Bandyopadhyay S, Yang H, Holden-Wiltse J, Kessler HA, Gill AL, Huyck H, Falsey AR, Topham DJ, Scheible KM, Caserta MT, Pryhuber GS, Gill SR

Microbiome.. 2018 October 266 (1):193. Epub 10/26/2018.

Neonatal hyperoxia depletes pulmonary vein cardiomyocytes in adult mice via mitochondrial oxidation.

Yee M, Cohen ED, Domm W, Porter GA, McDavid AN, O'Reilly MA

American journal of physiology. Lung cellular and molecular physiology.. 2018 May 1314 (5):L846-L859. Epub 01/18/2018.

The contribution of cell cycle to heterogeneity in single-cell RNA-seq data.

McDavid A, Finak G, Gottardo R

Nature biotechnology.. 2016 June 934 (6):591-3. Epub 1900 01 01.

Distinct activation thresholds of human conventional and innate-like memory T cells.

Slichter CK, McDavid A, Miller HW, Finak G, Seymour BJ, McNevin JP, Diaz G, Czartoski JL, McElrath MJ, Gottardo R, Prlic M

JCI insight.. 2016 June 21 (8)Epub 1900 01 01.

Inflammatory signals control human MAIT cell effector function

Slichter, Chloe K; McDavid, Andrew; Miller, Hannah; Finak, Greg; Seymour, Brenda; McNevin, John; Diaz, Gabriela; Czartoski, Julie; McElrath, Margaret J; Gottardo, Raphael;.

The Journal of Immunology. 2016; 196(1): 204-208.

Impact of Building Height and Volume on Cardiac Arrest Response Time.

Conway AB, McDavid A, Emert JM, Kudenchuk PJ, Stubbs BA, Rea TD, Yin L, Olsufka M, McCoy AM, Sayre MR

Prehospital emergency care.. 2016 20 (2):212-9. Epub 09/23/2015.

MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data.

Finak G, McDavid A, Yajima M, Deng J, Gersuk V, Shalek AK, Slichter CK, Miller HW, McElrath MJ, Prlic M, Linsley PS, Gottardo R

Genome biology.. 2015 December 1016 :278. Epub 12/10/2015.

Rarity of the Alzheimer disease-protective APP A673T variant in the United States.

Wang L, Naj AC, Graham RR, Crane PK, Kunkle BW, Cruchaga C, Murcia JD, Cannon-Albright L, Baldwin CT, Zetterberg H, Blennow K, Kukull WA, Faber KM, Schupf N, Norton MC, Tschanz JT, Munger RG, Corcoran CD, Rogaeva E, Lin C, Dombroski BA, Cantwell LB, Partch A, Valladares O, Hakonarson H, St George-Hyslop P, Green RC, Goate AM, Foroud TM, Carney RM, Larson EB, Behrens TW, Kauwe JS, Haines JL, Farrer LA, Pericak-Vance MA, Mayeux R, Schellenberg GD, , , Albert MS, Albin RL, Apostolova LG, Arnold SE, Barber R, Barmada MM, Barnes LL, Beach TG, Becker JT, Beecham GW, Beekly D, Bennett DA, Bigio EH, Bird TD, Blacker D, Boeve BF, Bowen JD, Boxer A, Burke JR, Buxbaum JD, Cairns NJ, Cao C, Carlson CS, Carroll SL, Chui HC, Clark DG, Cribbs DH, Crocco EA, DeCarli C, DeKosky ST, Demirci FY, Dick M, Dickson DW, Duara R, Ertekin-Taner N, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Glass JD, Graff-Radford NR, Growdon JH, Hamilton RL, Hamilton-Nelson KL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jarvik GP, Jicha GA, Jin L, Jun G, Kamboh MI, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Kramer JH, Kramer P, LaFerla FM, Lah JJ, Leverenz JB, Levey AI, Li G, Lieberman AP, Lopez OL, Lunetta KL, Lyketsos CG, Mack WJ, Marson DC, Martin ER, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam MM, Miller BL, Miller CA, Miller JW, Montine TJ, Morris JC, Murrell JR, Olichney JM, Parisi JE, Perry W, Peskind E, Petersen RC, Pierce A, Poon WW, Potter H, Quinn JF, Raj A, Raskind M, Reiman EM, Reisberg B, Reitz C, Ringman JM, Roberson ED, Rosen HJ, Rosenberg RN, Sano M, Saykin AJ, Schneider JA, Schneider LS, Seeley WW, Smith AG, Sonnen JA, Spina S, Stern RA, Tanzi RE, Thornton-Wells TA, Trojanowski JQ, Troncoso JC, Tsuang DW, Van Deerlin VM, Van Eldik LJ, Vardarajan BN, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Wishnek S, Woltjer RL, Wright CB, Younkin SG, Yu C, Yu L

JAMA neurology.. 2015 February 72 (2):209-16. Epub 1900 01 01.

Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study.

Naj AC, Jun G, Reitz C, Kunkle BW, Perry W, Park YS, Beecham GW, Rajbhandary RA, Hamilton-Nelson KL, Wang LS, Kauwe JS, Huentelman MJ, Myers AJ, Bird TD, Boeve BF, Baldwin CT, Jarvik GP, Crane PK, Rogaeva E, Barmada MM, Demirci FY, Cruchaga C, Kramer PL, Ertekin-Taner N, Hardy J, Graff-Radford NR, Green RC, Larson EB, St George-Hyslop PH, Buxbaum JD, Evans DA, Schneider JA, Lunetta KL, Kamboh MI, Saykin AJ, Reiman EM, De Jager PL, Bennett DA, Morris JC, Montine TJ, Goate AM, Blacker D, Tsuang DW, Hakonarson H, Kukull WA, Foroud TM, Martin ER, Haines JL, Mayeux RP, Farrer LA, Schellenberg GD, Pericak-Vance MA, , Albert MS, Albin RL, Apostolova LG, Arnold SE, Barber R, Barnes LL, Beach TG, Becker JT, Beekly D, Bigio EH, Bowen JD, Boxer A, Burke JR, Cairns NJ, Cantwell LB, Cao C, Carlson CS, Carney RM, Carrasquillo MM, Carroll SL, Chui HC, Clark DG, Corneveaux J, Cribbs DH, Crocco EA, DeCarli C, DeKosky ST, Dick M, Dickson DW, Duara R, Faber KM, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Glass JD, Growdon JH, Hamilton RL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jicha GA, Jin LW, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Kramer JH, LaFerla FM, Lah JJ, Leverenz JB, Levey AI, Li G, Lieberman AP, Lin CF, Lopez OL, Lyketsos CG, Mack WJ, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Murrell JR, Olichney JM, Pankratz VS, Parisi JE, Paulson HL, Peskind E, Petersen RC, Pierce A, Poon WW, Potter H, Quinn JF, Raj A, Raskind M, Reisberg B, Ringman JM, Roberson ED, Rosen HJ, Rosenberg RN, Sano M, Schneider LS, Seeley WW, Smith AG, Sonnen JA, Spina S, Stern RA, Tanzi RE, Thornton-Wells TA, Trojanowski JQ, Troncoso JC, Valladares O, Van Deerlin VM, Van Eldik LJ, Vardarajan BN, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Wishnek S, Woltjer RL, Wright CB, Younkin SG, Yu CE, Yu L

JAMA neurology.. 2014 November 71 (11):1394-404. Epub 1900 01 01.

Modeling bi-modality improves characterization of cell cycle on gene expression in single cells.

McDavid A, Dennis L, Danaher P, Finak G, Krouse M, Wang A, Webster P, Beechem J, Gottardo R

PLoS computational biology.. 2014 July 10 (7):e1003696. Epub 07/17/2014.

Mixture models for single-cell assays with applications to vaccine studies.

Finak G, McDavid A, Chattopadhyay P, Dominguez M, De Rosa S, Roederer M, Gottardo R

Biostatistics.. 2014 January 15 (1):87-101. Epub 07/24/2013.

Highly multiplexed quantitation of gene expression on single cells.

Dominguez MH, Chattopadhyay PK, Ma S, Lamoreaux L, McDavid A, Finak G, Gottardo R, Koup RA, Roederer M

Journal of immunological methods.. 2013 May 31391 (1-2):133-45. Epub 03/13/2013.

Genetic variation associated with circulating monocyte count in the eMERGE Network.

Crosslin DR, McDavid A, Weston N, Zheng X, Hart E, de Andrade M, Kullo IJ, McCarty CA, Doheny KF, Pugh E, Kho A, Hayes MG, Ritchie MD, Saip A, Crawford DC, Crane PK, Newton K, Carrell DS, Gallego CJ, Nalls MA, Li R, Mirel DB, Crenshaw A, Couper DJ, Tanaka T, van Rooij FJ, Chen MH, Smith AV, Zakai NA, Yango Q, Garcia M, Liu Y, Lumley T, Folsom AR, Reiner AP, Felix JF, Dehghan A, Wilson JG, Bis JC, Fox CS, Glazer NL, Cupples LA, Coresh J, Eiriksdottir G, Gudnason V, Bandinelli S, Frayling TM, Chakravarti A, van Duijn CM, Melzer D, Levy D, Boerwinkle E, Singleton AB, Hernandez DG, Longo DL, Witteman JC, Psaty BM, Ferrucci L, Harris TB, O'Donnell CJ, Ganesh SK, , Larson EB, Carlson CS, Jarvik GP,

Human molecular genetics.. 2013 May 1522 (10):2119-27. Epub 01/12/2013.

Efficient identification of rare variants in large populations: deep re-sequencing the CRP locus in the CARDIA study.

Chen CT, McDavid AN, Kahsai OJ, Zebari AS, Carlson CS

Nucleic acids research.. 2013 April 41 (7):e85. Epub 02/13/2013.

Data exploration, quality control and testing in single-cell qPCR-based gene expression experiments.

McDavid A, Finak G, Chattopadyay PK, Dominguez M, Lamoreaux L, Ma SS, Roederer M, Gottardo R

Bioinformatics.. 2013 February 1529 (4):461-7. Epub 12/24/2012.

Confirmation of the reported association of clonal chromosomal mosaicism with an increased risk of incident hematologic cancer.

Schick UM, McDavid A, Crane PK, Weston N, Ehrlich K, Newton KM, Wallace R, Bookman E, Harrison T, Aragaki A, Crosslin DR, Wang SS, Reiner AP, Jackson RD, Peters U, Larson EB, Jarvik GP, Carlson CS

PloS one.. 2013 8 (3):e59823. Epub 03/22/2013.

Enhancing the power of genetic association studies through the use of silver standard cases derived from electronic medical records.

McDavid A, Crane PK, Newton KM, Crosslin DR, McCormick W, Weston N, Ehrlich K, Hart E, Harrison R, Kukull WA, Rottscheit C, Peissig P, Stefanski E, McCarty CA, Zuvich RL, Ritchie MD, Haines JL, Denny JC, Schellenberg GD, de Andrade M, Kullo I, Li R, Mirel D, Crenshaw A, Bowen JD, Li G, Tsuang D, McCurry S, Teri L, Larson EB, Jarvik GP, Carlson CS

PloS one.. 2013 8 (6):e63481. Epub 06/10/2013.

Novel late-onset Alzheimer disease loci variants associate with brain gene expression.

Allen M, Zou F, Chai HS, Younkin CS, Crook J, Pankratz VS, Carrasquillo MM, Rowley CN, Nair AA, Middha S, Maharjan S, Nguyen T, Ma L, Malphrus KG, Palusak R, Lincoln S, Bisceglio G, Georgescu C, Schultz D, Rakhshan F, Kolbert CP, Jen J, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Schellenberg GD, Petersen RC, Graff-Radford NR, Dickson DW, Younkin SG, Ertekin-Taner N, , Apostolova LG, Arnold SE, Baldwin CT, Barber R, Barmada MM, Beach T, Beecham GW, Beekly D, Bennett DA, Bigio EH, Bird TD, Blacker D, Boeve BF, Bowen JD, Boxer A, Burke JR, Buros J, Buxbaum JD, Cairns NJ, Cantwell LB, Cao C, Carlson CS, Carney RM, Carroll SL, Chui HC, Clark DG, Corneveaux J, Cotman CW, Crane PK, Cruchaga C, Cummings JL, De Jager PL, DeCarli C, DeKosky ST, Demirci FY, Diaz-Arrastia R, Dick M, Dombroski BA, Duara R, Ellis WD, Evans D, Faber KM, Fallon KB, Farlow MR, Ferris S, Foroud TM, Frosch M, Galasko DR, Gallins PJ, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Gilman S, Giordani B, Glass JD, Goate AM, Green RC, Growdon JH, Hakonarson H, Hamilton RL, Hardy J, Harrell LE, Head E, Honig LS, Huentelman MJ, Hulette CM, Hyman BT, Jarvik GP, Jicha GA, Jin LW, Jun G, Kamboh MI, Karlawish J, Karydas A, Kauwe JS, Kaye JA, Kennedy N, Kim R, Koo EH, Kowall NW, Kramer P, Kukull WA, Lah JJ, Larson EB, Levey AI, Lieberman AP, Lopez OL, Lunetta KL, Mack WJ, Marson DC, Martin ER, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Montine TJ, Morris JC, Myers AJ, Naj AC, Nowotny P, Parisi JE, Perl DP, Peskind E, Poon WW, Potter H, Quinn JF, Raj A, Rajbhandary RA, Raskind M, Reiman EM, Reisberg B, Reitz C, Ringman JM, Roberson ED, Rogaeva E, Rosenberg RN, Sano M, Saykin AJ, Schneider JA, Schneider LS, Seeley W, Shelanski ML, Slifer MA, Smith CD, Sonnen JA, Spina S, St George-Hyslop P, Stern RA, Tanzi RE, Trojanowski JQ, Troncoso JC, Tsuang DW, Van Deerlin VM, Vardarajan BN, Vinters HV, Vonsattel JP, Wang LS, Weintraub S, Welsh-Bohmer KA, Williamson J, Woltjer RL

Neurology.. 2012 July 1779 (3):221-8. Epub 06/20/2012.

Examination of ancestral informative markers and self-reported race with tumor characteristics of breast cancer among Black and White women.

Reding KW, Carlson CS, Kahsai O, Chen CC, McDavid A, Doody DR, Chen C, Ornelas I, Lowe K, Bernstein L, Weiss L, McDonald JA, Simon MS, Strom B, Marchbanks PA, Burkman R, Spirtas R, Liff JM, Malone KE

Breast cancer research and treatment.. 2012 July 134 (2):801-9. Epub 05/31/2012.

Detectable clonal mosaicism from birth to old age and its relationship to cancer.

Laurie CC, Laurie CA, Rice K, Doheny KF, Zelnick LR, McHugh CP, Ling H, Hetrick KN, Pugh EW, Amos C, Wei Q, Wang LE, Lee JE, Barnes KC, Hansel NN, Mathias R, Daley D, Beaty TH, Scott AF, Ruczinski I, Scharpf RB, Bierut LJ, Hartz SM, Landi MT, Freedman ND, Goldin LR, Ginsburg D, Li J, Desch KC, Strom SS, Blot WJ, Signorello LB, Ingles SA, Chanock SJ, Berndt SI, Le Marchand L, Henderson BE, Monroe KR, Heit JA, de Andrade M, Armasu SM, Regnier C, Lowe WL, Hayes MG, Marazita ML, Feingold E, Murray JC, Melbye M, Feenstra B, Kang JH, Wiggs JL, Jarvik GP, McDavid AN, Seshan VE, Mirel DB, Crenshaw A, Sharopova N, Wise A, Shen J, Crosslin DR, Levine DM, Zheng X, Udren JI, Bennett S, Nelson SC, Gogarten SM, Conomos MP, Heagerty P, Manolio T, Pasquale LR, Haiman CA, Caporaso N, Weir BS

Nature genetics.. 2012 May 644 (6):642-50. Epub 05/06/2012.

Genetic variants associated with the white blood cell count in 13,923 subjects in the eMERGE Network.

Crosslin DR, McDavid A, Weston N, Nelson SC, Zheng X, Hart E, de Andrade M, Kullo IJ, McCarty CA, Doheny KF, Pugh E, Kho A, Hayes MG, Pretel S, Saip A, Ritchie MD, Crawford DC, Crane PK, Newton K, Li R, Mirel DB, Crenshaw A, Larson EB, Carlson CS, Jarvik GP,

Human genetics.. 2012 April 131 (4):639-52. Epub 10/30/2011.

Pitfalls of merging GWAS data: lessons learned in the eMERGE network and quality control procedures to maintain high data quality.

Zuvich RL, Armstrong LL, Bielinski SJ, Bradford Y, Carlson CS, Crawford DC, Crenshaw AT, de Andrade M, Doheny KF, Haines JL, Hayes MG, Jarvik GP, Jiang L, Kullo IJ, Li R, Ling H, Manolio TA, Matsumoto ME, McCarty CA, McDavid AN, Mirel DB, Olson LM, Paschall JE, Pugh EW, Rasmussen LV, Rasmussen-Torvik LJ, Turner SD, Wilke RA, Ritchie MD

Genetic epidemiology.. 2011 December 35 (8):887-98. Epub 1900 01 01.

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.

Naj AC, Jun G, Beecham GW, Wang LS, Vardarajan BN, Buros J, Gallins PJ, Buxbaum JD, Jarvik GP, Crane PK, Larson EB, Bird TD, Boeve BF, Graff-Radford NR, De Jager PL, Evans D, Schneider JA, Carrasquillo MM, Ertekin-Taner N, Younkin SG, Cruchaga C, Kauwe JS, Nowotny P, Kramer P, Hardy J, Huentelman MJ, Myers AJ, Barmada MM, Demirci FY, Baldwin CT, Green RC, Rogaeva E, St George-Hyslop P, Arnold SE, Barber R, Beach T, Bigio EH, Bowen JD, Boxer A, Burke JR, Cairns NJ, Carlson CS, Carney RM, Carroll SL, Chui HC, Clark DG, Corneveaux J, Cotman CW, Cummings JL, DeCarli C, DeKosky ST, Diaz-Arrastia R, Dick M, Dickson DW, Ellis WG, Faber KM, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Gilman S, Giordani B, Glass JD, Growdon JH, Hamilton RL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jicha GA, Jin LW, Johnson N, Karlawish J, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Lah JJ, Levey AI, Lieberman AP, Lopez OL, Mack WJ, Marson DC, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Parisi JE, Perl DP, Peskind E, Petersen RC, Poon WW, Quinn JF, Rajbhandary RA, Raskind M, Reisberg B, Ringman JM, Roberson ED, Rosenberg RN, Sano M, Schneider LS, Seeley W, Shelanski ML, Slifer MA, Smith CD, Sonnen JA, Spina S, Stern RA, Tanzi RE, Trojanowski JQ, Troncoso JC, Van Deerlin VM, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Woltjer RL, Cantwell LB, Dombroski BA, Beekly D, Lunetta KL, Martin ER, Kamboh MI, Saykin AJ, Reiman EM, Bennett DA, Morris JC, Montine TJ, Goate AM, Blacker D, Tsuang DW, Hakonarson H, Kukull WA, Foroud TM, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Schellenberg GD

Nature genetics.. 2011 May 43 (5):436-41. Epub 04/03/2011.

Quality control procedures for genome-wide association studies.

Turner S, Armstrong LL, Bradford Y, Carlson CS, Crawford DC, Crenshaw AT, de Andrade M, Doheny KF, Haines JL, Hayes G, Jarvik G, Jiang L, Kullo IJ, Li R, Ling H, Manolio TA, Matsumoto M, McCarty CA, McDavid AN, Mirel DB, Paschall JE, Pugh EW, Rasmussen LV, Wilke RA, Zuvich RL, Ritchie MD

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