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Douglas M. Anderson, Ph.D.

Douglas M. Anderson, Ph.D.

Research Lab

Anderson Lab

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About Me

Faculty Appointments

Assistant Professor - Department of Medicine, Aab Cardiovascular Research Institute (SMD)

Assistant Professor - Department of Pharmacology and Physiology (SMD) - Joint

Credentials

Post-doctoral Training & Residency

Postdoctoral Fellow, Laboratory of Eric N. Olson, Ph.D.,
UT Southwestern Medical Center, Dallas, TX 2013 - 2016

Education

PhD | Arizona State University. Molecular & Cellular Biology. 2010

BS | Arizona State University. Biology. 2003

Postdoctoral Fellow | UT Southwestern Medical Center, Dallas, Texas. Biology. 2003

Awards

Award for Excellence in Postdoctoral Research at UT Southwestern. 2014 - 2015

Research

Our lab investigates the regulatory pathways that control striated muscle development and function, and how defects in those pathways can give rise to human disease. The development of striated muscle is controlled by conserved networks of regulatory proteins and noncoding RNAs that coordinate the e...
Our lab investigates the regulatory pathways that control striated muscle development and function, and how defects in those pathways can give rise to human disease. The development of striated muscle is controlled by conserved networks of regulatory proteins and noncoding RNAs that coordinate the expression of genes involved in muscle growth, morphogenesis, differentiation and contractility. Our research focuses on the role of muscle-enriched RNA-binding proteins and long noncoding RNAs (lncRNAs) as novel regulators of muscle development and disease. Unexpectedly, we've found that many annotated lncRNAs, in fact, encode small functional proteins, called micropeptides, which play important roles in regulating intracellular signaling. By investigating the function of these regulatory proteins and noncoding RNAs, we aim to uncover novel insights into the regulatory mechanisms important for muscle biology. Our lab utilizes and generates a variety of biochemical and cell-based assays and both gain- and loss-of-function mouse models.

Publications

Journal Articles

LncRNAs at the heart of development and disease

Anderson KM; Anderson DM.

2022; .

A myocardin-adjacent lncRNA balances SRF-dependent gene transcription in the heart.

Anderson DM; Anderson KM; Nelson BR; McAnally JR; Bezprozvannaya S; Shelton JM; Bassel-Duby R; Olson EN.

Genes & Development. 2021; 35: 835-840.

Widespread control of calcium signaling by a family of SERCA-inhibiting micropeptides

Anderson KM; Anderson DM; McAnally JR; Shelton JM; Bassel-Duby R; Olson EN.

Science Signaling. 2016; 9(457): pp. ra119.

Transcription of the non-coding RNA upperhand controls Hand2 expression and heart development

Anderson KM; Anderson DM; McAnally JR; Shelton JM; Bassel-Duby R; Olson EN.

Nature. 2016; 539: 433-436.

A micropeptide encoded by a transcript annotated as long noncoding RNA enhances SERCA activity in muscle.

Nelson BR*; Makarewich CA*; Anderson DM; Winders BR; Troupes CD; Wu F; Reese AL; McAnally J; Chen X; Kavalali ET; Cannon SC; Houser SR; Bassel-Duby R; Olson EN.

Science. 2016; 351: 271-275.

Anderson DM*; Cannavino J*; Li H, Anderson KM; Nelson BR; McAnally JR; Bezprozvannaya S; Liu Y; Lin W; Liu N, Bassel-Duby R; Olson EN.

Severe muscle wasting and denervation

A micropeptide encoded by a putative long noncoding RNA regulates muscle performance

Anderson DM; Anderson KM; Chang CL; Makarewich CA; Nelson BR; McAnally JR; Kasaragod P; Shelton JM,; Liou J; Bassel-Duby R; Olson EN.

Cell. 2015; 160: 595-606.

A mouse model for adult cardiac-specific gene deletion with CRISPR/Cas9

Carroll KJ; Makarewich CA; McAnally J; Anderson DM; Zentilin L; Liu N; Giacca M; Bassel-Duby R; Olson EN.

Proceedings of the National Academy of Sciences USA. 2015; 113: 338-343.

Small open reading frames pack a big punch in cardiac calcium regulation

Nelson BR; Anderson DM; Olson EN.

Circulation Research. 2014; 114: 18-20.

Skeletal muscle-specific T-tubule protein STAC3 mediates voltage-induced Ca2+ release and contractility

Nelson BR; Wu F; Liu Y; Anderson DM; McAnally J; Lin W; Cannon SC; Bassel-Duby R; Olson EN.

Proceedings of the National Academy of Sciences USA. 2013; 110: 11881-6.

Regulation of mesenchymal-to-epithelial transition by PARAXIS during somitogenesis

Rowton M; Ramos P; Anderson DM; Rhee JM; Cunliffe HE; Rawls A.

Developmental Dynamics. 2013; 242: 1332-44.

Characterization of the DNA-binding properties of the Mohawk homeobox transcription factor

Anderson DM; George R; Noyes MB; Rowton M; Liu W; Jiang R; Wolfe SA; Wilson-Rawls J; Rawls A.

Journal of Biological Chemistry. 2012; 287: 35351-9.

Mouse sperm exhibit chemotaxis to allurin, a truncated member of the cysteine-rich secretory protein family

Burnett LA; Anderson DM; Rawls A; Bieber AL; Chandler DE.

Developmental Biology. 2011; 360: 318-328.

The homeobox gene Mohawk represses transcription by recruiting the Sin3A/HDAC co-repressor complex

Anderson DM; Beres BJ,; Wilson-Rawls J; Rawls A.

Developmental Dynamics. 2009; 238: 572-580.

Book chapter: Development of Muscle and Somites. In: Inborn Errors of Development: The Molecular Basis of Clinical Disorders of Morphogenesis.

Anderson, DM (Author); Rawls, JA (Author) ; Rhee, JM (Author).

Oxford University Press ISBN: 9780195306910. 2008; .

Identification of oscillatory genes in somitogenesis from functional genomic analysis of a human mesenchymal stem cell model.

William DA; Saitta B; Gibson JD; Traas J; Markov V; Gonzalez DM; Sewell W; Anderson DM; Pratt SC; Rappaport EF; Kusumi K.

Developmental Biology. 2007; 305: 172-86.

Mohawk is a novel homeobox gene expressed in the developing mouse embryo

Anderson DM; Arredondo J; Hahn K; Valente G; Martin JF; Wilson-Rawls J; Rawls A.

Developmental Dynamics. 2006; 235: 792-801.