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Patrick D. Brophy, M.D., M.H.C.D.S.

Contact Information

Faculty Appointments


Dr. Brophy's clinical interests include; Neonatal and congenital genetic renal anomalies, Acute Kidney Injury/Critical Care Nephrology, Lifecourse healthcare delivery, Healthcare Delivery Sciences as well as Technology use in improving healthcare access and reducing disparity.

Dr. Brophy is a member of the American Board Pediatrics (ABP) and the Association of Medicine School Pediatric Department Chairs (AMSPDC) and serves on the finance committee of the American Board of Medical Specialties (ABMS) and on the program planning committee for the Society for Pediatric Research (SPR).


Dr. Brophy has experience in basic, translational, clinical healthcare delivery research and has been part of the leadership team for the Integrated Special Populations component of the University of Iowa's CTSA and was part of the lifecourse research group at the CC-CHOC prior to its dissolution by the NIH. As an extension of improving clinical care access in the state of Iowa, he founded the Signal Center for Health Innovation and has developed a telehealth portfolio that can be used for teaching and research as well (

From a clinical research perspective he has had a strong track record of research collaboration with the ppCRRT and ppAKI consortia, which has resulted in multiple peer reviewed publications and significantly impacted on care management of patients requiring acute dialysis and those with Acute Kidney Injury (AKI). Dr. Brophy's basic sciences laboratory and research focuses on the molecular genetics and functional mechanisms of normal and abnormal development of the kidneys and genitourinary (GU) tract. His genetics lab utilizes predominantly murine animal models for this work.

He also has a translational interest in the field of metabolomics of neonatal acute kidney injury and is a part of an international collaborative group- The AWAKEN group. He established a collaborative group using metabolomics in the investigation of neonatal (premature infant) AKI and has also partnered with several other well-known Pediatric investigators in the area of the proteomics of Neonatal AKI as a Co-Investigator in the Recombinant Erythropoietin for Protection of Infant Renal Disease (REPaIReD) trial.

As a result of his long standing work in the area of renal development related to this work, he initiated and developed a collaborative genetics network ( in the area of renal agenesis which is a condition well known to the Pediatric Nephrology community and developmental biology community.



MD | Canada-U Saskatchewan Coll Med

Post-doctoral Training & Residency

07/01/1998 - 06/30/2001
Fellowship in Pediatric Nephrology at University of Michigan Medical School

07/01/1995 - 06/30/1998
Residency in Pediatrics at University of Manitoba (Canada)

07/01/1994 - 06/30/1995
Internship in Pediatrics at University of Manitoba (Canada)

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Runner up for Innovations in Clinical Care award (UI Healthcare) for UIeCare/UIeSalud- direct to consumer virtual care platform
Sponsor: University of Iowa Physicians
Location: University of Iowa

Parenting (Baby talk) Magazine "Health Care Hero" Award:One of 7 Pediatric care specialists recognized in the country for innova
Sponsor: American Academy of Pediatrics

University of Iowa Physicians: Innovations in Clinical Care award (UI Healthcare)
Sponsor: University of Iowa

Peregrine Charities Research Fund recipient
Sponsor: Peregrine Charities Research

Business Corridor Journal "Health Care Hero" Award
Sponsor: Business Corridor Journal

University of Iowa Children's Hospital, Department of Pediatrics program development award
Sponsor: University of Iowa Children's Hospital

Eleanor Sueppel Research Fund Recipient
Sponsor: Eleanor Sueppel Research Fund

2006 - 2007
Named to Marquis' Who's Who in Medicine

Elected to the "Society for Pediatric Research"

Runner up Mott Children's Hospital Clinical Service award
Sponsor: Mott Children's Hospital

Department of Pediatrics – Young Investigator for Basic Science Research Honorable Mention (Faculty Cate
Sponsor: University of Michigan
Location: University of Michigan

Wayne Jones Family Fund Award for Young Faculty Basic Science Research ($ 12,500 US)
Sponsor: University of Michigan from an Endowment
Location: University of Michigan

American Society of Nephrology Carl Gottschalk Award and grant for Basic Science
Sponsor: American Society of Nephrology

Recipient of the 1st Annual Elizabeth E. Kennedy Foundation Award for Young Faculty Basic Science Research ($ 10,000 US) present
Sponsor: from Endowment through the Elizabeth Kennedy Foundation
Location: University of Michigan

Top 10 Teachers in Pediatrics for Medical Students
Sponsor: University of Michigan

University of Michigan, Department of Pediatrics – Young Investigator for Basic Science Research Award (Faculty Category)
Sponsor: University of Michigan

Society for Pediatric Research – Outstanding Basic Science Research Award (Fellows Category)
Sponsor: Society for Pediatric Research

International Pediatric Transplant Association Travel Award
Sponsor: International Pediatric Transplant Association

American Society of Pediatric Nephrology Travel Grant
Sponsor: American Society of Pediatric Nephrology

American Society of Nephrology Professional Travel Grant
Sponsor: American Society of Nephrology Professional Development Seminar

American Society of Nephrology Basic Science Conference Travel Grant
Sponsor: American Society of Nephrology Basic Science Conference

Medical Research Council of Canada, Resident Research Award
Sponsor: Medical Research Council of Canada

Resident Research Foundation Award- for "The Expression of RHAMM and Alpha-Smooth Muscle Actin in Glomerulonephritis"

1988 - 1990
University of Saskatchewan-University Undergraduate Scholarship for Academic Excellence

Resident Research Foundation Award-for "Sequential expression of Alpha Smooth Muscle Actin and The Receptor for Hyaluronan Media

1987 - 1988
University of Regina-University Undergraduate Scholarship for Academic Excellence

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Journal Articles

Goldstein SL, Akcan-Arikan A, Alobaidi R, Askenazi DJ, Bagshaw SM, Barhight M, Barreto E, Bayrakci B, Bignall ONR, Bjornstad E, Brophy PD, Chanchlani R, Charlton JR, Conroy AL, Deep A, Devarajan P, Dolan K, Fuhrman DY, Gist KM, Gorga SM, Greenberg JH, Hasson D, Ulrich EH, Iyengar A, Jetton JG, Krawczeski C, Meigs L, Menon S, Morgan J, Morgan CJ, Mottes T, Neumayr TM, Ricci Z, Selewski D, Soranno DE, Starr M, Stanski NL, Sutherland SM, Symons J, Tavares MS, Vega MW, Zappitelli M, Ronco C, Mehta RL, Kellum J, Ostermann M, Basu RK, . "Consensus-Based Recommendations on Priority Activities to Address Acute Kidney Injury in Children: A Modified Delphi Consensus Statement." JAMA network open.. 2022 Sep 1; 5(9):e2229442. Epub 2022 Sep 01.

Weidemann DK, Ashoor IA, Soranno DE, Sheth R, Carter C, Brophy PD. "Moving the Needle Toward Fair Compensation in Pediatric Nephrology." Frontiers in pediatrics.. 2022 10:849826. Epub 2022 Mar 10.

van der Plas E, Solomon MA, Hopkins L, Koscik T, Schultz J, Brophy PD, Nopoulos PC, Harshman LA. "Global and regional white matter fractional anisotropy in children with chronic kidney disease." The Journal of pediatrics.. 2021 Nov 7; Epub 2021 Nov 07.

Books & Chapters

Book Title: Association Between Early Caffeine Citrate Administration and Risk of Acute Kidney Injury in Preterm Neonates: Results From the AWAKEN Study
Author List: Harer MW, Askenazi DJ, Boohaker LJ, Carmody JB, Griffin RL, Guillet R, Selewski DT, Swanson JR, Charlton JR; Neonatal Kidney Collaborative (NKC)
Published By: JAMA Pediatr 2018

Book Title: Incidence of neonatal hypertension from a large multicenter study [Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates-AWAKEN]
Author List: Kraut EJ, Boohaker LJ, Askenazi DJ, Fletcher J, Kent AL; Neonatal Kidney Collaborative (NKC)
Published By: Pediatric Res. 2018

Chapter Title: Creatinine Clearance in Pediatrics
Book Title: Encyclopedia of Intensive Care Medicine in Kellum
Author List: Nester C. and Brophy PD
Published By: Springer 2012