Stephano Spano Mello, Ph.D.

Contact Information

Biography

Research

The Mello lab is aimed at understanding how nuclear proteins and non-coding RNAs (ncRNAs) regulate gene transcription in pancreatic preneoplastic lesions, gaining knowledge of the process of cellular transformation and tumor initiation. To date, very little is known about the different processes and cell types that precede cancer. We are committed to describing and characterizing novel genes that play a role during early steps of tumor initiation.

We utilize physiologically relevant in vivo models and a systems biology approach, integrating multiple types of genomic data to delineate important cellular events in tumor initiation. Our research provide insights on early detection of malignant lesions, and in the development of novel strategies to treat pancreatic cancer, pancreatitis and diabetes.

Credentials

Education

1998
BSc | Brazil - University of Sao Paulo
Biological Science

2002
MSc | Brazil-Fac Med Ribeirao Preto
Genetics

2006
PhD | Brazil-Fac Med Ribeirao Preto
Genetics

Post-doctoral Training & Residency

2009 - 2014
Postgraduate Research in Cancer Genetics, Stanford University, Stanford, CA

2007 - 2009
Postgraduate Research in Microbiology, University of Sao Paulo, Sao Paulo, Brazil

Awards

2023
Early Investigator Advancement Program (EIAP) scholar
Sponsor: NIH/ NCI

2017
J. Martin Brown Award for Excellence in Radiation Sciences
Sponsor: Stanford University, CA

2008
Individual Grant (support for meeting attendance), nº 07/59639-0
Sponsor: FAPESP, Brazil

2007
Young Scientist prize
Sponsor: EMS Society, Brazil

2005
Environmental Mutagen Society (EMS) Travel Award, 9th International EMS Conference
Sponsor: EMS

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Publications

Journal Articles

8/28/2023
Cazarin J, DeRollo RE, Shahidan SNABA, Burchett JB, Mwangi D, Krishnaiah S, Hsieh AL, Walton ZE, Brooks R, Mello SS, Weljie AM, Dang CV, Altman BJ. "MYC disrupts transcriptional and metabolic circadian oscillations in cancer and promotes enhanced biosynthesis." PLoS genetics.. 2023 Aug 28; 19(8):e1010904. Epub 2023 Aug 28.

7/6/2023
Liu X, Burke RM, Lighthouse JK, Baker CD, Dirkx RA, Kang B, Chakraborty Y, Mickelsen DM, Twardowski J, Mello SS, Ashton JM, Small EM. "P53 Regulates the Extent of Fibroblast Proliferation and Fibrosis in Left Ventricle Pressure Overload." Circulation research.. 2023 Jul 6; Epub 2023 Jul 06.

3/7/2023
Mello SS, Flowers BM, Mazur PK, Lee JJ, Müller F, Denny SK, Ferreira S, Hanson K, Kim SK, Greenleaf WJ, Wood LD, Attardi LD. "Multifaceted role for p53 in pancreatic cancer suppression." Proceedings of the National Academy of Sciences of the United States of America.. 2023 Mar 7; 120(10):e2211937120. Epub 2023 Feb 27.

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