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Stephano Spano Mello, Ph.D.

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Faculty Appointments



The Mello lab is aimed at understanding how nuclear proteins and non-coding RNAs (ncRNAs) regulate gene transcription in pancreatic preneoplastic lesions, gaining knowledge of the process of cellular transformation and tumor initiation. To date, very little is known about the different processes and cell types that precede cancer. We are committed to describing and characterizing novel genes that play a role during early steps of tumor initiation.

We utilize physiologically relevant in vivo models and a systems biology approach, integrating multiple types of genomic data to delineate important cellular events in tumor initiation. Our research provide insights on early detection of malignant lesions, and in the development of novel strategies to treat pancreatic cancer, pancreatitis and diabetes.


Journal Articles

Bieging-Rolett KT, Kaiser AM, Morgens DW, Boutelle AM, Seoane JA, Van Nostrand EL, Zhu C, Houlihan SL, Mello SS, Yee BA, McClendon J, Pierce SE, Winters IP, Wang M, Connolly AJ, Lowe SW, Curtis C, Yeo GW, Winslow MM, Bassik MC, Attardi LD. "Zmat3 Is a Key Splicing Regulator in the p53 Tumor Suppression Program." Molecular cell.. 2020 Nov 5; 80(3):452-469.e9.

Valente LJ, Tarangelo A, Li AM, Naciri M, Raj N, Boutelle AM, Li Y, Mello SS, Bieging-Rolett K, DeBerardinis RJ, Ye J, Dixon SJ, Attardi LD. "p53 deficiency triggers dysregulation of diverse cellular processes in physiological oxygen." The Journal of cell biology.. 2020 Nov 2; 219(11)

Huang J, Sachdeva M, Xu E, Robinson TJ, Luo L, Ma Y, Williams N, Lopez O, Cervia LD, Yuan F, Qin X, Zhang D, Owzar K, Gokgoz N, Seto A, Okada T, Singer S, Andrulis IL, Wunder J, Lazar AJ, Rubin BP, Pipho K, Mello SS, Giudice J, Kirsch DG. "The long non-coding RNA NEAT1 promotes sarcoma metastasis by regulating RNA splicing pathways." Molecular cancer research : MCR.. 2020 Jun 19; Epub 2020 Jun 19.