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Stephano Spano Mello, Ph.D.

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The Mello lab is aimed at understanding how nuclear proteins and non-coding RNAs (ncRNAs) regulate gene transcription in pancreatic preneoplastic lesions, gaining knowledge of the process of cellular transformation and tumor initiation. To date, very little is known about the different processes and cell types that precede cancer. We are committed to describing and characterizing novel genes that play a role during early steps of tumor initiation.

We utilize physiologically relevant in vivo models and a systems biology approach, integrating multiple types of genomic data to delineate important cellular events in tumor initiation. Our research provide insights on early detection of malignant lesions, and in the development of novel strategies to treat pancreatic cancer, pancreatitis and diabetes.


Journal Articles

Mello SS, Attardi LD. "Deciphering p53 signaling in tumor suppression." Current opinion in cell biology.. 2018 Apr 0; 51:65-72. Epub 2017 Nov 28.

Mello SS, Attardi LD. "Neat-en-ing up our understanding of p53 pathways in tumor suppression." Cell cycle.. 2018 17(13):1527-1535. Epub 2018 Jul 31.

Mello SS, Valente LJ, Raj N, Seoane JA, Flowers BM, McClendon J, Bieging-Rolett KT, Lee J, Ivanochko D, Kozak MM, Chang DT, Longacre TA, Koong AC, Arrowsmith CH, Kim SK, Vogel H, Wood LD, Hruban RH, Curtis C, Attardi LD. "A p53 Super-tumor Suppressor Reveals a Tumor Suppressive p53-Ptpn14-Yap Axis in Pancreatic Cancer." Cancer cell.. 2017 Oct 9; 32(4):460-473.e6.