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Patrick J. Murphy, Ph.D.

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Research Labs

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Locations

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 633
Rochester, NY 14642

Faculty Appointments

Biography

Research

The Murphy lab investigates the mechanisms that activate or silence genes as cells transition from one state to another. In very early embryos, stem cells begin to divide and change. Through this process, called differentiation, tissues start to form, and all the cell types of the organism begin to arise. Differentiation relies on a highly coordinated series of gene activation and silencing events. As cells divide during differentiation, changes in gene expression provide each cell type with a specific identity and function. In a similar sense, when the gene expression patterns of normal adult cells change inappropriately, the cell identity also changes, and this can lead to carcinogenesis. Presently, it is unknown what molecular machinery allows a cell to transition from one gene expression state to another.

Publications

Journal Articles

12/16/2022
 , Higgins AM, Berry LR, Lorenzi E, Murthy S, McQuilten Z, Mouncey PR, Al-Beidh F, Annane D, Arabi YM, Beane A, van Bentum-Puijk W, Bhimani Z, Bonten MJM, Bradbury CA, Brunkhorst FM, Burrell A, Buzgau A, Buxton M, Charles WN, Cove M, Detry MA, Estcourt LJ, Fagbodun EO, Fitzgerald M, Girard TD, Goligher EC, Goossens H, Haniffa R, Hills T, Horvat CM, Huang DT, Ichihara N, Lamontagne F, Marshall JC, McAuley DF, McGlothlin A, McGuinness SP, McVerry BJ, Neal MD, Nichol AD, Parke RL, Parker JC, Parry-Billings K, Peters SEC, Reyes LF, Rowan KM, Saito H, Santos MS, Saunders CT, Serpa-Neto A, Seymour CW, Shankar-Hari M, Stronach LM, Turgeon AF, Turner AM, van de Veerdonk FL, Zarychanski R, Green C, Lewis RJ, Angus DC, McArthur CJ, Berry S, Derde LPG, Gordon AC, Webb SA, Lawler PR. "Long-term (180-Day) Outcomes in Critically Ill Patients With COVID-19 in the REMAP-CAP Randomized Clinical Trial." JAMA.. 2022 Dec 16; Epub 2022 Dec 16.

7/12/2022
Chen S, Rosin LF, Pegoraro G, Moshkovich N, Murphy PJ, Yu G, Lei EP. "NURF301 contributes to gypsy chromatin insulator-mediated nuclear organization." Nucleic acids research.. 2022 Jul 12; Epub 2022 Jul 12.

1/4/2022
Hickey GJ, Wike CL, Nie X, Guo Y, Tan M, Murphy PJ, Cairns BR. "Establishment of developmental gene silencing by ordered polycomb complex recruitment in early zebrafish embryos." eLife.. 2022 Jan 4; 11Epub 2022 Jan 04.

Books & Chapters

2014
Chapter Title: Epigenetic Changes in the Paternal Germline
Book Title: Transgenerational Epigenetics : Evidence and Debate
Author List: Murphy KE, Murphy PJ, and Carrell DT
Edited By: T. Tollefsbol
Published By: Oxford: Academic Press 2014

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