CONTACT INFORMATIONCREDENTIALSPUBLICATIONSPatrick J. Murphy, Ph.D.Contact InformationResearch LabsVisit Lab WebsiteLocationsUniversity of Rochester Medical CenterSchool of Medicine and Dentistry601 Elmwood Ave, Box 633Rochester, NY 14642Faculty AppointmentsAssistant Professor - Department of Biomedical Genetics (SMD) Assistant Professor - Department of Biology RC (RC) - JointBiographyResearchThe Murphy lab investigates the mechanisms that activate or silence genes as cells transition from one state to another. In very early embryos, stem cells begin to divide and change. Through this process, called differentiation, tissues start to form, and all the cell types of the organism begin to arise. Differentiation relies on a highly coordinated series of gene activation and silencing events. As cells divide during differentiation, changes in gene expression provide each cell type with a specific identity and function. In a similar sense, when the gene expression patterns of normal adult cells change inappropriately, the cell identity also changes, and this can lead to carcinogenesis. Presently, it is unknown what molecular machinery allows a cell to transition from one gene expression state to another.PublicationsJournal Articles10/14/2021Akdogan-Ozdilek B, Duval KL, Meng FW, Murphy PJ, Goll MG. "Identification of chromatin states during zebrafish gastrulation using CUT&RUN and CUT&Tag." Developmental dynamics : an official publication of the American Association of Anatomists.. 2021 Oct 14; Epub 2021 Oct 14. 8/17/2021Stefanelli G, Makowski CE, Brimble MA, Hall M, Reda A, Creighton SD, Leonetti AM, McLean TAB, Zakaria JM, Baumbach J, Greer CB, Davidoff AM, Walters BJ, Murphy PJ, Zovkic IB. "The histone chaperone Anp32e regulates memory formation, transcription, and dendritic morphology by regulating steady-state H2A.Z binding in neurons." Cell reports.. 2021 Aug 17; 36(7):109551. 5/20/2021Meng FW, Murphy PJ. "Rolling uphill: in vivo reacquisition of pluripotency during cranial neural crest differentiation." Communications biology.. 2021 May 20; 4(1):626. Epub 2021 May 20. Books & Chapters2014 Chapter Title: Epigenetic Changes in the Paternal Germline Book Title: Transgenerational Epigenetics : Evidence and Debate Author List: Murphy KE, Murphy PJ, and Carrell DT Edited By: T. Tollefsbol Published By: Oxford: Academic Press 2014VIEW ALL PUBLICATIONSClose WindowSchedule an appointment with Patrick J. Murphy, Ph.D.Please answer the following questions to help us find the right appointment for you.Important: If you believe that you have a medical or psychiatric emergency, please call 911 or go to the nearest hospital. This website is not intended for emergency care.Have you seen this provider in the last 2 years?YesNoExisting Patient Schedule or request a follow up appointment online through MyChart. If you do not have a MyChart account, please close this window and call the appointment phone number. Patrick J. Murphy, Ph.D. is currently scheduling for the following appointment type(s): Our policy does not permit patients to establish care with multiple providers within the same practice or specialty without prior approval. If you choose a new provider in the same office, we will cancel the appointment. Please contact the office directly with questions on this policy.