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Patrick J. Murphy, Ph.D.

Contact Information

Research Labs

Faculty Appointments

Biography

Research

The Murphy lab investigates the mechanisms that activate or silence genes as cells transition from one state to another. In very early embryos, stem cells begin to divide and change. Through this process, called differentiation, tissues start to form, and all the cell types of the organism begin to arise. Differentiation relies on a highly coordinated series of gene activation and silencing events. As cells divide during differentiation, changes in gene expression provide each cell type with a specific identity and function. In a similar sense, when the gene expression patterns of normal adult cells change inappropriately, the cell identity also changes, and this can lead to carcinogenesis. Presently, it is unknown what molecular machinery allows a cell to transition from one gene expression state to another.

Publications

Journal Articles

10/14/2021
Akdogan-Ozdilek B, Duval KL, Meng FW, Murphy PJ, Goll MG. "Identification of chromatin states during zebrafish gastrulation using CUT&RUN and CUT&Tag." Developmental dynamics : an official publication of the American Association of Anatomists.. 2021 Oct 14; Epub 2021 Oct 14.

8/17/2021
Stefanelli G, Makowski CE, Brimble MA, Hall M, Reda A, Creighton SD, Leonetti AM, McLean TAB, Zakaria JM, Baumbach J, Greer CB, Davidoff AM, Walters BJ, Murphy PJ, Zovkic IB. "The histone chaperone Anp32e regulates memory formation, transcription, and dendritic morphology by regulating steady-state H2A.Z binding in neurons." Cell reports.. 2021 Aug 17; 36(7):109551.

5/20/2021
Meng FW, Murphy PJ. "Rolling uphill: in vivo reacquisition of pluripotency during cranial neural crest differentiation." Communications biology.. 2021 May 20; 4(1):626. Epub 2021 May 20.

Books & Chapters

2014
Chapter Title: Epigenetic Changes in the Paternal Germline
Book Title: Transgenerational Epigenetics : Evidence and Debate
Author List: Murphy KE, Murphy PJ, and Carrell DT
Edited By: T. Tollefsbol
Published By: Oxford: Academic Press 2014

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