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Zoltan N. Oltvai, M.D.

Zoltan N. Oltvai, M.D.

UR Medicine Labs

UR Medicine Faculty The University of Rochester Medical Faculty Group (URMFG) consists of over 900 specialist and primary care providers spanning 19 departments. URMFG is certified by the National Committee for Quality Assurance.
Accountable Health Partner Accountable Health Partners (AHP) is a network of over 2,000 community and UR medical faculty and a dozen leading hospitals throughout the region. AHP offers a full range of care.
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Contact

Office (585) 275-7574

About Me

Certified Specialties

Pathology, Clinical Pathology/Laboratory Medicine - American Board of Pathology

Faculty Appointments

Professor - Department of Pathology and Laboratory Medicine (SMD)

Credentials

Residency & Fellowship

Fellowship, Molecular Genetic Pathology, University of Minnesota Medical School. 2018 - 2019

Residency, Pathology - Clinical, Washington University in St. Louis. 1989 - 1994

Fellowship, Yale University School of Medicine. 1985 - 1989

Education

MD | Semmelweis University (Hungary). 1984

Research

My overall collaborative research interest is on using computational modeling and system biology-based approaches to gain insight into the principles of cellular functions, and develop improved diagnostic and therapeutic approaches for disease pathologies with a main focus on the molecular pathology...
My overall collaborative research interest is on using computational modeling and system biology-based approaches to gain insight into the principles of cellular functions, and develop improved diagnostic and therapeutic approaches for disease pathologies with a main focus on the molecular pathology of cancer. Currently active research projects are described below.

Research Lab

Publications

Journal Articles

Repurposing of the Cardiovascular Drug Statin for the Treatment of Cancers: Efficacy of Statin-Dipyridamole Combination Treatment in Melanoma Cell Lines.

Irie N, Mizoguchi K, Warita T, Nakano M, Sasaki K, Tashiro J, Osaki T, Ishikawa T, Oltvai ZN, Warita K

Biomedicines.. 2024 March 2112 (3)Epub 03/21/2024.

Clinicopathologic and Molecular Characterization of Anorectal Neuroendocrine Carcinomas Reveals Human Papillomavirus, p53 and c-Myc as Alternative Mechanisms of Carcinogenesis.

Cox AJ, Crowe WE, Yang Q, Zhang B, Oltvai ZN, Liao X

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.. 2023 July 28 :100295. Epub 07/28/2023.

Efficient Lung Cancer Molecular Diagnostics by Combining Next Generation Sequencing with Reflex Idylla Genefusion Assay Testing.

Nkosi D, George GV, Liu H, Buldo M, Velez MJ, Oltvai ZN

Genes.. 2023 July 2814 (8)Epub 07/28/2023.

HMG-CoA reductase degrader, SR-12813, counteracts statin-induced upregulation of HMG-CoA reductase and augments the anticancer effect of atorvastatin.

Zhou Y, Tashiro J, Kamatani S, Irie N, Suzuki A, Ishikawa T, Warita K, Oltvai ZN, Warita T

Biochemical and biophysical research communications.. 2023 July 27677 :13-19. Epub 07/27/2023.

Expression of housekeeping genes varies depending on mevalonate pathway inhibition in cancer cells.

Irie N, Warita K, Tashiro J, Zhou Y, Ishikawa T, Oltvai ZN, Warita T

Heliyon.. 2023 July 9 (7):e18017. Epub 07/08/2023.

Clonal cytopenia of undetermined significance (CCUS)-associated reversion of donor-derived, transient ?? T-cell large granular clonal lymphocytosis, emerging post-transplant in a patient with a history of ?? T-cell large granular lymphocytic leukemia.

El Hussein S, Evans AG, Fitzsimmons JM, Leong N, Buldo M, Segal JP, Jajosky AN, Rothberg PG, Liesveld JL, Oltvai ZN

Cold Spring Harbor molecular case studies.. 2023 April 9 (2)Epub 05/09/2023.

Alterations in the omics profiles in mevalonate pathway-inhibited cancer cells.

Warita T, Irie N, Zhou Y, Tashiro J, Sugiura A, Oltvai ZN, Warita K

Life sciences.. 2022 November 28 :121249. Epub 11/28/2022.

Incidental discovery of acute myeloid leukemia during liquid biopsy of a lung cancer patient.

Nkosi D, Miller CA, Jajosky AN, Oltvai ZN

Cold Spring Harbor molecular case studies.. 2022 June 8 (4)Epub 06/22/2022.

Utility of Select Gene Mutation Detection in Tumors by the Idylla Rapid Multiplex PCR Platform in Comparison to Next-Generation Sequencing.

Nkosi D, Casler VL, Syposs CR, Oltvai ZN

Genes.. 2022 April 2913 (5)Epub 04/29/2022.

Concomitant attenuation of HMGCR expression and activity enhances the growth inhibitory effect of atorvastatin on TGF-β-treated epithelial cancer cells.

Warita K, Ishikawa T, Sugiura A, Tashiro J, Shimakura H, Hosaka YZ, Ohta KI, Warita T, Oltvai ZN

Scientific reports.. 2021 June 1711 (1):12763. Epub 06/17/2021.

Assessing acquired resistance to IDH1 inhibitor therapy by full-exon sequencing and structural modeling.

Oltvai ZN, Harley SE, Koes D, Michel S, Warlick ED, Nelson AC, Yohe S, Mroz P

Cold Spring Harbor molecular case studies.. 2021 April 7 (2)Epub 04/08/2021.

Neonatal respiratory failure due to novel compound heterozygous mutations in the ABCA3 lipid transporter.

Oltvai ZN, Smith EA, Wiens K, Nogee LM, Luquette M, Nelson AC, Wikenheiser-Brokamp KA

Cold Spring Harbor molecular case studies.. 2020 June 6 (3)Epub 06/12/2020.

Rhapsody: predicting the pathogenicity of human missense variants.

Ponzoni L, Peñaherrera DA, Oltvai ZN, Bahar I

Bioinformatics.. 2020 May 136 (10):3084-3092. Epub 1900 01 01.

Adjustment in tumbling rates improves bacterial chemotaxis on obstacle-laden terrains.

Rashid S, Long Z, Singh S, Kohram M, Vashistha H, Navlakha S, Salman H, Oltvai ZN, Bar-Joseph Z

Proceedings of the National Academy of Sciences of the United States of America.. 2019 June 11116 (24):11770-11775. Epub 05/24/2019.

Statin drugs to reduce breast cancer recurrence and mortality.

Beckwitt CH, Brufsky A, Oltvai ZN, Wells A

Breast cancer research : BCR.. 2018 November 2020 (1):144. Epub 11/20/2018.

Statins attenuate outgrowth of breast cancer metastases.

Beckwitt CH, Clark AM, Ma B, Whaley D, Oltvai ZN, Wells A

British journal of cancer.. 2018 October 119 (9):1094-1105. Epub 11/07/2018.

Concomitant attenuation of HMG-CoA reductase expression potentiates the cancer cell growth-inhibitory effect of statins and expands their efficacy in tumor cells with epithelial characteristics.

Ishikawa T, Hosaka YZ, Beckwitt C, Wells A, Oltvai ZN, Warita K

Oncotarget.. 2018 June 299 (50):29304-29315. Epub 06/29/2018.

Shift from stochastic to spatially-ordered expression of serine-glycine synthesis enzymes in 3D microtumors.

Singh M, Warita K, Warita T, Faeder JR, Lee REC, Sant S, Oltvai ZN

Scientific reports.. 2018 June 208 (1):9388. Epub 06/20/2018.

Biomarker identification for statin sensitivity of cancer cell lines.

Raghu VK, Beckwitt CH, Warita K, Wells A, Benos PV, Oltvai ZN

Biochemical and biophysical research communications.. 2018 January 1495 (1):659-665. Epub 11/14/2017.

Quantitative assessment of cell fate decision between autophagy and apoptosis.

Liu B, Oltvai ZN, Bay?r H, Silverman GA, Pak SC, Perlmutter DH, Bahar I

Scientific reports.. 2017 December 147 (1):17605. Epub 12/14/2017.

Cell-cell communication enhances bacterial chemotaxis toward external attractants.

Long Z, Quaife B, Salman H, Oltvai ZN

Scientific reports.. 2017 October 97 (1):12855. Epub 10/09/2017.

Macromolecular crowding explains overflow metabolism in cells.

Vazquez A, Oltvai ZN

Scientific reports.. 2016 August 36 :31007. Epub 08/03/2016.

BalestraWeb: efficient online evaluation of drug-target interactions.

Cobanoglu MC, Oltvai ZN, Taylor DL, Bahar I

Bioinformatics.. 2015 January 131 (1):131-3. Epub 09/05/2014.

Statin-induced mevalonate pathway inhibition attenuates the growth of mesenchymal-like cancer cells that lack functional E-cadherin mediated cell cohesion.

Warita K, Warita T, Beckwitt CH, Schurdak ME, Vazquez A, Wells A, Oltvai ZN

Scientific reports.. 2014 December 234 :7593. Epub 12/23/2014.

Significance of p53 dynamics in regulating apoptosis in response to ionizing radiation, and polypharmacological strategies.

Liu B, Bhatt D, Oltvai ZN, Greenberger JS, Bahar I

Scientific reports.. 2014 September 14 :6245. Epub 09/01/2014.

Predicting drug-target interactions using probabilistic matrix factorization.

Cobanoglu MC, Liu C, Hu F, Oltvai ZN, Bahar I

Journal of chemical information and modeling.. 2013 December 2353 (12):3399-409. Epub 12/10/2013.

Carbon catabolite repression correlates with the maintenance of near invariant molecular crowding in proliferating E. coli cells.

Zhou Y, Vazquez A, Wise A, Warita T, Warita K, Bar-Joseph Z, Oltvai ZN

BMC systems biology.. 2013 December 127 :138. Epub 12/12/2013.

The metabolic demands of cancer cells are coupled to their size and protein synthesis rates.

Dolfi SC, Chan LL, Qiu J, Tedeschi PM, Bertino JR, Hirshfield KM, Oltvai ZN, Vazquez A

Cancer & metabolism.. 2013 November 71 (1):20. Epub 11/07/2013.

Workflow organization in pathology.

Park S, Pantanowitz L, Parwani AV, Wells A, Oltvai ZN

Clinics in laboratory medicine.. 2012 December 32 (4):601-22. Epub 1900 01 01.

Ongoing technological revolution. Preface.

Wells A, Oltvai ZN

Clinics in laboratory medicine.. 2012 December 32 (4):ix-x. Epub 1900 01 01.

Matching experiments across species using expression values and textual information.

Wise A, Oltvai ZN, Bar-Joseph Z

Bioinformatics.. 2012 June 1528 (12):i258-64. Epub 1900 01 01.

Identification of motions in membrane proteins by elastic network models and their experimental validation.

Isin B, Tirupula KC, Oltvai ZN, Klein-Seetharaman J, Bahar I

Methods in molecular biology.. 2012 914 :285-317. Epub 1900 01 01.

Identifying ligand binding conformations of the ?2-adrenergic receptor by using its agonists as computational probes.

Isin B, Estiu G, Wiest O, Oltvai ZN

PloS one.. 2012 7 (12):e50186. Epub 12/31/2012.

Molecular crowding defines a common origin for the Warburg effect in proliferating cells and the lactate threshold in muscle physiology.

Vazquez A, Oltvai ZN

PloS one.. 2011 April 296 (4):e19538. Epub 04/29/2011.

Serine biosynthesis with one carbon catabolism and the glycine cleavage system represents a novel pathway for ATP generation.

Vazquez A, Markert EK, Oltvai ZN

PloS one.. 2011 6 (11):e25881. Epub 11/02/2011.

Cross-species queries of large gene expression databases.

Le HS, Oltvai ZN, Bar-Joseph Z

Bioinformatics.. 2010 October 126 (19):2416-23. Epub 08/11/2010.

Catabolic efficiency of aerobic glycolysis: the Warburg effect revisited.

Vazquez A, Liu J, Zhou Y, Oltvai ZN

BMC systems biology.. 2010 May 64 :58. Epub 05/06/2010.

Computational disease modeling - fact or fiction?

Tegnér JN, Compte A, Auffray C, An G, Cedersund G, Clermont G, Gutkin B, Oltvai ZN, Stephan KE, Thomas R, Villoslada P

BMC systems biology.. 2009 June 43 :56. Epub 06/04/2009.

Comparative genome-scale metabolic reconstruction and flux balance analysis of multiple Staphylococcus aureus genomes identify novel antimicrobial drug targets.

Lee DS, Burd H, Liu J, Almaas E, Wiest O, Barabási AL, Oltvai ZN, Kapatral V

Journal of bacteriology.. 2009 June 191 (12):4015-24. Epub 04/17/2009.

Impact of limited solvent capacity on metabolic rate, enzyme activities, and metabolite concentrations of S. cerevisiae glycolysis.

Vazquez A, de Menezes MA, Barabási AL, Oltvai ZN

PLoS computational biology.. 2008 October 4 (10):e1000195. Epub 10/10/2008.

A semi-supervised method for predicting transcription factor-gene interactions in Escherichia coli.

Ernst J, Beg QK, Kay KA, Balázsi G, Oltvai ZN, Bar-Joseph Z

PLoS computational biology.. 2008 March 284 (3):e1000044. Epub 03/28/2008.

Impact of the solvent capacity constraint on E. coli metabolism.

Vazquez A, Beg QK, Demenezes MA, Ernst J, Bar-Joseph Z, Barabási AL, Boros LG, Oltvai ZN

BMC systems biology.. 2008 January 232 :7. Epub 01/23/2008.

Shaping specificity in signaling networks.

Albert R, Oltvai ZN

Nature genetics.. 2007 March 39 (3):286-7. Epub 1900 01 01.

A pitfall in series of microarrays: the position of probes affects the cross-correlation of gene expression profiles.

Balázsi G, Oltvai ZN

Methods in molecular biology.. 2007 377 :153-62. Epub 1900 01 01.

Topological basis of signal integration in the transcriptional-regulatory network of the yeast, Saccharomyces cerevisiae.

Farkas IJ, Wu C, Chennubhotla C, Bahar I, Oltvai ZN

BMC bioinformatics.. 2006 October 287 :478. Epub 10/28/2006.

Exploring transcriptional regulatory networks in the worm.

Farkas IJ, Beg QK, Oltvai ZN

Cell.. 2006 June 16125 (6):1032-4. Epub 1900 01 01.

The activity reaction core and plasticity of metabolic networks.

Almaas E, Oltvai ZN, Barabási AL

PLoS computational biology.. 2005 December 1 (7):e68. Epub 12/16/2005.

Sensing your surroundings: how transcription-regulatory networks of the cell discern environmental signals.

Balázsi G, Oltvai ZN

Science's STKE : signal transduction knowledge environment. 2005 May 32005 (282):pe20. Epub 05/03/2005.

Genome-scale identification of conditionally essential genes in E. coli by DNA microarrays.

Tong X, Campbell JW, Balázsi G, Kay KA, Wanner BL, Gerdes SY, Oltvai ZN

Biochemical and biophysical research communications.. 2004 September 10322 (1):347-54. Epub 1900 01 01.

Functional and topological characterization of protein interaction networks.

Yook SH, Oltvai ZN, Barabási AL

Proteomics.. 2004 April 4 (4):928-42. Epub 1900 01 01.

Network biology: understanding the cell's functional organization.

Barabási AL, Oltvai ZN

Nature reviews. Genetics.. 2004 February 5 (2):101-13. Epub 1900 01 01.

Aggregation of topological motifs in the Escherichia coli transcriptional regulatory network.

Dobrin R, Beg QK, Barabási AL, Oltvai ZN

BMC bioinformatics.. 2004 January 305 :10. Epub 01/30/2004.

Bioinformatics analysis of experimentally determined protein complexes in the yeast Saccharomyces cerevisiae.

Dezso Z, Oltvai ZN, Barabási AL

Genome research.. 2003 November 13 (11):2450-4. Epub 10/14/2003.

Spurious spatial periodicity of co-expression in microarray data due to printing design.

Balázsi G, Kay KA, Barabási AL, Oltvai ZN

Nucleic acids research.. 2003 August 131 (15):4425-33. Epub 1900 01 01.

Bcl-2 promotes premature senescence induced by oncogenic Ras.

Tombor B, Rundell K, Oltvai ZN

Biochemical and biophysical research communications.. 2003 April 11303 (3):800-7. Epub 1900 01 01.

Systems biology. Life's complexity pyramid.

Oltvai ZN, Barabási AL

Science.. 2002 October 25298 (5594):763-4. Epub 1900 01 01.