Skip to main content
Explore URMC
menu

Darren R. Carpizo, M.D., Ph.D.

Publications

Showing all 65 journal articles & 3 books available

Journal Articles

7/21/2021
Ciner AT, Hochster HS, August DA, Carpizo DR, Spencer KR. "Delayed cytokine release syndrome after neoadjuvant nivolumab: a case report and literature review." Immunotherapy.. 2021 Jul 21; Epub 2021 Jul 21.

2/4/2021
Gilleran JA, Yu X, Blayney AJ, Bencivenga AF, Na B, Augeri DJ, Blanden AR, Kimball SD, Loh SN, Roberge JY, Carpizo DR. "Benzothiazolyl and Benzoxazoyl Hydrazones Function as Zinc Metallochaperones to Reactivate Mutant p53." Journal of medicinal chemistry.. 2021 Feb 4; Epub 2021 Feb 04.

1/7/2021
Meltzer RS, Kooby DA, Switchenko JM, Datta J, Carpizo DR, Maithel SK, Shah MM. "ASO Visual Abstract: Does Major Pancreatic Surgery have Utility for Nonagenarians with Pancreas Cancer?" Annals of surgical oncology.. 2021 Jan 7; Epub 2021 Jan 07.

1/2021
Greco SH, August DA, Shah MM, Chen C, Moore DF, Masanam M, Turner AL, Jabbour SK, Javidian P, Grandhi MS, Kennedy TJ, Alexander HR, Carpizo DR, Langan RC. "Neoadjuvant therapy is associated with lower margin positivity rates after Pancreaticoduodenectomy in T1 and T2 pancreatic head cancers: An analysis of the National Cancer Database." . 2021 Jan 0; 3:22-28. Epub 2020 Dec 16.

12/2/2020
Blanden AR, Yu X, Blayney AJ, Demas C, Ha JH, Liu Y, Withers T, Carpizo DR, Loh SN. "Zinc shapes the folding landscape of p53 and establishes a pathway for reactivating structurally diverse cancer mutants." eLife.. 2020 Dec 2; 9Epub 2020 Dec 02.

11/3/2020
Meltzer RS, Kooby DA, Switchenko JM, Datta J, Carpizo DR, Maithel SK, Shah MM. "Does Major Pancreatic Surgery Have Utility in Nonagenarians with Pancreas Cancer?" Annals of surgical oncology.. 2020 Nov 3; Epub 2020 Nov 03.

10/23/2020
Muaddi H, D'Angelica M, Wiseman JT, Dillhoff M, Latchana N, Roke R, Ko YJ, Carpizo D, Spencer K, Fields RC, Williams G, Aucejo F, Acevedo-Moreno LA, Billingsley KG, Walker BS, Mayo SC, Karanicolas PJ. "Safety and feasibility of initiating a hepatic artery infusion pump chemotherapy program for unresectable colorectal liver metastases: A multicenter, retrospective cohort study." Journal of surgical oncology.. 2020 Oct 23; Epub 2020 Oct 23.

6/10/2020
Shah MM, Meyer BI, Rhee K, NeMoyer RE, Lin Y, Tzeng CD, Jabbour SK, Kennedy TJ, Nosher JL, Kooby DA, Maithel SK, Carpizo DR. "Conditional survival analysis of hepatocellular carcinoma." Journal of surgical oncology.. 2020 Jun 10; Epub 2020 Jun 10.

5/12/2020
Kangas-Dick A, Gall V, Hilden P, Turner A, Greenbaum A, Sesti J, Paul S, Carpizo D, Kennedy T, Sadaria Grandhi M, Alexander HR, Wang S, Geffner S, August D, Langan RC. "Disparities in utilization of services for racial and ethnic minorities with hepatocellular carcinoma associated with hepatitis C." Surgery.. 2020 May 12; Epub 2020 May 12.

4/21/2020
Park KU, Mamounas EP, Katz MHG, Unzeitig G, Carpizo D, You YN, Francescatti A, Hunt KK, Boughey JC. "Clinical Trials for the Surgical Oncologist: Opportunities and Hurdles." Annals of surgical oncology.. 2020 Apr 21; Epub 2020 Apr 21.

1/1/2020
Contractor T, Clausen R, Harris G, Rosenfeld J, Carpizo D, Tang L, Harris C. "IGF2 drives formation of ileal neuroendocrine tumors in patients and mice." Endocrine-related cancer.. 2020 Jan 1; Epub 2020 Jan 01.

2020
Shah MM, NeMoyer RE, Greco SH, Chen C, Moore DF, Grandhi MS, Langan RC, Kennedy TJ, Javidian P, Jabbour SK, Alexander HR, August DA, Carpizo DR. "Subcategorizing T1 Staging in Pancreatic Adenocarcinoma Predicts Survival in Patients Undergoing Resection: An Analysis of the National Cancer Database." . 2020 6(1):64-72. Epub 2020 Jul 14.

2020
Khullar K, Patel NM, Anderson C, Chundury A, Carpizo D, Feingold D, Grandhi M, Hochster H, Jani K, Kennedy T, Langan R, Spencer K, August D, Jabbour SK. "The Evolving Role of Radiotherapy in Locally Advanced Rectal Cancer and the Potential for Nonoperative Management." Oncology & hematology review.. 2020 16(1):43-51. Epub 2020 Apr 27.

12/2019
Chi A, Adams BE, Sesti J, Paul S, Turner AL, August D, Carpizo D, Kennedy T, Grandhi M, Alexander HR, Libutti SK, Geffner S, Langan RC. "Outcomes Following Major Oncologic Operations for Non-AIDS-Defining Cancers in the HIV Population: A Matched Comparison to the General Population." World journal of surgery.. 2019 Dec 0; 43(12):3019-3026.

8/2019
Zaman S, Yu X, Bencivenga AF, Blanden AR, Liu Y, Withers T, Na B, Blayney AJ, Gilleran J, Boothman DA, Loh SN, Kimball SD, Carpizo DR. "Combinatorial Therapy of Zinc Metallochaperones with Mutant p53 Reactivation and Diminished Copper Binding." Molecular cancer therapeutics.. 2019 Aug 0; 18(8):1355-1365. Epub 2019 Jun 13.

6/2019
Ali ND, Donohue K, Zandieh S, Chen C, Moore D, Poplin E, Shah MM, Nosher J, Gui B, Jabbour SK, Spencer K, Carpizo DR. "Conditional Survival Analysis of Metastatic Colorectal Cancer Patients Living ?24 Months: A Single Institutional Study." American journal of clinical oncology.. 2019 Jun 0; 42(6):512-518.

3/2019
Hasan O, Greco S, Kennedy T, Carpizo D, Kempf J, Nosher J. "Aberrant arc between the common hepatic artery and a replaced right hepatic artery resulting in misperfusion in a patient with a hepatic arterial infusion pump." Surgical and radiologic anatomy : SRA.. 2019 Mar 0; 41(3):355-358. Epub 2019 Jan 05.

2/22/2019
Dave YA, Gupta A, Shah MM, Carpizo D. "Liver haematoma as a presentation of peliosis hepatis." BMJ case reports.. 2019 Feb 22; 12(2)Epub 2019 Feb 22.

1/29/2019
Yu X, Carpizo DR. "Flipping the "switch" on mutant p53 by zinc metallochaperones: how a brief pulse of zinc can reactivate mutant p53 to kill cancer." Oncotarget.. 2019 Jan 29; 10(9):918-919. Epub 2019 Jan 29.

2019
Na B, Yu X, Withers T, Gilleran J, Yao M, Foo TK, Chen C, Moore D, Lin Y, Kimball SD, Xia B, Ganesan S, Carpizo DR. "Therapeutic targeting of and mutant breast cancer through mutant p53 reactivation." NPJ breast cancer.. 2019 5:14. Epub 2019 Apr 15.

2019
Sayan M, Yegya-Raman N, Greco SH, Gui B, Zhang A, Chundury A, Grandhi MS, Hochster HS, Kennedy TJ, Langan RC, Malhotra U, Rustgi VK, Shah MM, Spencer KR, Carpizo DR, Nosher JL, Jabbour SK. "Rethinking the Role of Radiation Therapy in the Treatment of Unresectable Hepatocellular Carcinoma: A Data Driven Treatment Algorithm for Optimizing Outcomes." Frontiers in oncology.. 2019 9:345. Epub 2019 Jun 18.

2019
Langan RC, Carpizo DR. "Modernizing the clinical risk score to more accurately predict survival following resection of colorectal liver metastases." . 2019 4:49. Epub 2019 Jun 26.

9/15/2018
Yu X, Kogan S, Chen Y, Tsang AT, Withers T, Lin H, Gilleran J, Buckley B, Moore D, Bertino J, Chan C, Kimball SD, Loh SN, Carpizo DR. "Zinc Metallochaperones Reactivate Mutant p53 Using an ON/OFF Switch Mechanism: A New Paradigm in Cancer Therapeutics." Clinical cancer research : an official journal of the American Association for Cancer Research.. 2018 Sep 15; 24(18):4505-4517. Epub 2018 Jun 18.

9/2018
Gui B, Weiner AA, Nosher J, Lu SE, Foltz GM, Hasan O, Kim SK, Gendel V, Mani NB, Carpizo DR, Saad NE, Kennedy TJ, Zuckerman DA, Olsen JR, Parikh PJ, Jabbour SK. "Assessment of the Albumin-Bilirubin (ALBI) Grade as a Prognostic Indicator for Hepatocellular Carcinoma Patients Treated With Radioembolization." American journal of clinical oncology.. 2018 Sep 0; 41(9):861-866.

8/2018
Weiner AA, Gui B, Newman NB, Nosher JL, Yousseff F, Lu SE, Foltz GM, Carpizo D, Lowenthal J, Zuckerman DA, Benson B, Olsen JR, Jabbour SK, Parikh PJ. "Predictors of Survival after Yttrium-90 Radioembolization for Colorectal Cancer Liver Metastases." Journal of vascular and interventional radiology : JVIR.. 2018 Aug 0; 29(8):1094-1100. Epub 2018 May 10.

8/2018
Yegya-Raman N, Shah MM, Grandhi MS, Poplin E, August DA, Kennedy TJ, Malhotra U, Spencer KR, Carpizo DR, Jabbour SK. "Adjuvant therapeutic strategies for resectable pancreatic adenocarcinoma." . 2018 Aug 0; 1Epub 2018 Aug 06.

6/17/2018
Casabianca AS, Shah MM, Carpizo D. "Accessory bile duct: a rare but important anatomical variant." BMJ case reports.. 2018 Jun 17; 2018Epub 2018 Jun 17.

5/29/2018
Kogan S, Carpizo DR. "Zinc Metallochaperones as Mutant p53 Reactivators: A New Paradigm in Cancer Therapeutics." Cancers.. 2018 May 29; 10(6)Epub 2018 May 29.

5/17/2018
Shimada K, Reznik E, Stokes ME, Krishnamoorthy L, Bos PH, Song Y, Quartararo CE, Pagano NC, Carpizo DR, deCarvalho AC, Lo DC, Stockwell BR. "Copper-Binding Small Molecule Induces Oxidative Stress and Cell-Cycle Arrest in Glioblastoma-Patient-Derived Cells." Cell chemical biology.. 2018 May 17; 25(5):585-594.e7. Epub 2018 Mar 22.

2018
NeMoyer RE, Shah MM, Hasan O, Nosher JL, Carpizo DR. "A novel combined interventional radiologic and hepatobiliary surgical approach to a complex traumatic hilar biliary stricture." International journal of surgery case reports.. 2018 44:185-190. Epub 2018 Mar 03.

8/2017
Tsang AT, Dudgeon C, Yi L, Yu X, Goraczniak R, Donohue K, Kogan S, Brenneman MA, Ho ES, Gunderson SI, Carpizo DR. "U1 Adaptors Suppress the Oncogenic Axis in Human Pancreatic Cancer Xenografts." Molecular cancer therapeutics.. 2017 Aug 0; 16(8):1445-1455. Epub 2017 Apr 04.

7/2017
Cercek A, Gendel V, Jabbour S, Moore D, Chen C, Nosher J, Capanu M, Chou JF, Boucher T, Kemeny N, Carpizo DR. "A Comparison of Yttrium-90 Microsphere Radioembolization to Hepatic Arterial Infusional Chemotherapy for Patients with Chemo-refractory Hepatic Colorectal Metastases." Current treatment options in oncology.. 2017 Jul 0; 18(7):42.

6/2017
Yu X, Blanden A, Tsang AT, Zaman S, Liu Y, Gilleran J, Bencivenga AF, Kimball SD, Loh SN, Carpizo DR. "Thiosemicarbazones Functioning as Zinc Metallochaperones to Reactivate Mutant p53." Molecular pharmacology.. 2017 Jun 0; 91(6):567-575. Epub 2017 Mar 20.

12/2016
Kogan S, Carpizo D. "Pharmacological targeting of mutant p53." . 2016 Dec 0; 5(6):698-706.

10/2016
Blanden AR, Yu X, Loh SN, Levine AJ, Carpizo DR. "Corrigendum to "Reactivating mutant p53 using small molecules as zinc metallochaperones: awakening a sleeping giant in cancer" [Drug Discov. Today 20 (11) (2015) 1391-1397]." Drug discovery today.. 2016 Oct 0; 21(10):1728. Epub 2016 Jul 29.

1/2016
Eng OS, Arlow RL, Moore D, Chen C, Langenfeld JE, August DA, Carpizo DR. "Fluid administration and morbidity in transhiatal esophagectomy." The Journal of surgical research.. 2016 Jan 0; 200(1):91-7. Epub 2015 Jul 16.

11/2015
Lin H, Yu X, Eng OS, Buckley B, Kong AN, Bertino JR, Carpizo DR, Gounder MK. "A sensitive liquid chromatography-mass spectrometry bioanalytical assay for a novel anticancer candidate--ZMC1." Biomedical chromatography : BMC.. 2015 Nov 0; 29(11):1708-14. Epub 2015 May 05.

11/2015
Blanden AR, Yu X, Loh SN, Levine AJ, Carpizo DR. "Reactivating mutant p53 using small molecules as zinc metallochaperones: awakening a sleeping giant in cancer." Drug discovery today.. 2015 Nov 0; 20(11):1391-7. Epub 2015 Jul 20.

8/28/2015
Yue W, Zheng X, Lin Y, Yang CS, Xu Q, Carpizo D, Huang H, DiPaola RS, Tan XL. "Metformin combined with aspirin significantly inhibit pancreatic cancer cell growth in vitro and in vivo by suppressing anti-apoptotic proteins Mcl-1 and Bcl-2." Oncotarget.. 2015 Aug 28; 6(25):21208-24.

7/15/2015
Chiou SH, Winters IP, Wang J, Naranjo S, Dudgeon C, Tamburini FB, Brady JJ, Yang D, Grüner BM, Chuang CH, Caswell DR, Zeng H, Chu P, Kim GE, Carpizo DR, Kim SK, Winslow MM. "Pancreatic cancer modeling using retrograde viral vector delivery and in vivo CRISPR/Cas9-mediated somatic genome editing." Genes & development.. 2015 Jul 15; 29(14):1576-85. Epub 2015 Jul 15.

6/2015
Newman NB, Jabbour SK, Hon JD, Berman JJ, Malik D, Carpizo D, Moss RA. "Hepatocellular Carcinoma Without Cirrhosis Presenting With Hypercalcemia: Case Report and Literature Review." . 2015 Jun 0; 5(2):163-6. Epub 2015 Apr 18.

6/2015
Patel AA, Nagarajan S, Scher ED, Schonewolf CA, Balasubramanian S, Poplin E, Moss R, August D, Carpizo D, Melstrom L, Jabbour SK. "Early vs. Late Chemoradiation Therapy and the Postoperative Interval to Adjuvant Therapy Do Not Correspond to Local Recurrence in Resected Pancreatic Cancer." . 2015 Jun 0; 5(2)Epub 2015 Apr 02.

5/2015
Blanden AR, Yu X, Wolfe AJ, Gilleran JA, Augeri DJ, O'Dell RS, Olson EC, Kimball SD, Emge TJ, Movileanu L, Carpizo DR, Loh SN. "Synthetic metallochaperone ZMC1 rescues mutant p53 conformation by transporting zinc into cells as an ionophore." Molecular pharmacology.. 2015 May 0; 87(5):825-31. Epub 2015 Feb 20.

3/15/2015
Eng OS, Tsang AT, Moore D, Chen C, Narayanan S, Gannon CJ, August DA, Carpizo DR, Melstrom LG. "Outcomes of microwave ablation for colorectal cancer liver metastases: a single center experience." Journal of surgical oncology.. 2015 Mar 15; 111(4):410-3. Epub 2014 Dec 29.

3/15/2015
Eng OS, Melstrom LG, Carpizo DR. "The relationship of perioperative fluid administration to outcomes in colorectal and pancreatic surgery: a review of the literature." Journal of surgical oncology.. 2015 Mar 15; 111(4):472-7. Epub 2015 Feb 02.

10/15/2014
Yu X, Blanden AR, Narayanan S, Jayakumar L, Lubin D, Augeri D, Kimball SD, Loh SN, Carpizo DR. "Small molecule restoration of wildtype structure and function of mutant p53 using a novel zinc-metallochaperone based mechanism." Oncotarget.. 2014 Oct 15; 5(19):8879-92.

7/2014
Yu X, Narayanan S, Vazquez A, Carpizo DR. "Small molecule compounds targeting the p53 pathway: are we finally making progress?" Apoptosis : an international journal on programmed cell death.. 2014 Jul 0; 19(7):1055-68.

2/2014
Carpizo DR, Gensure RH, Yu X, Gendel VM, Greene SJ, Moore DF, Jabbour SK, Nosher JL. "Pilot study of angiogenic response to yttrium-90 radioembolization with resin microspheres." Journal of vascular and interventional radiology : JVIR.. 2014 Feb 0; 25(2):297-306.e1. Epub 2013 Dec 20.

10/2013
Eng OS, Goswami J, Moore D, Chen C, Brumbaugh J, Gannon CJ, August DA, Carpizo DR. "Safety and efficacy of LigaSure usage in pancreaticoduodenectomy." HPB : the official journal of the International Hepato Pancreato Biliary Association.. 2013 Oct 0; 15(10):747-52. Epub 2013 Jun 19.

9/2013
Eng OS, Goswami J, Moore D, Chen C, Gannon CJ, August DA, Carpizo DR. "Intraoperative fluid administration is associated with perioperative outcomes in pancreaticoduodenectomy: a single center retrospective analysis." Journal of surgical oncology.. 2013 Sep 0; 108(4):242-7. Epub 2013 Aug 01.

2013
Shanker BA, Eng OS, Gendel V, Nosher J, Carpizo DR. "Repair of a post-hepatectomy posterior sectoral duct injury secondary to anomalous bile duct anatomy using a novel combined surgical-interventional radiologic approach." . 2013 2013:202315. Epub 2013 Sep 12.

10/2012
Gensure RH, Foran DJ, Lee VM, Gendel VM, Jabbour SK, Carpizo DR, Nosher JL, Yang L. "Evaluation of hepatic tumor response to yttrium-90 radioembolization therapy using texture signatures generated from contrast-enhanced CT images." Academic radiology.. 2012 Oct 0; 19(10):1201-7. Epub 2012 Jul 26.

5/15/2012
Yu X, Vazquez A, Levine AJ, Carpizo DR. "Allele-specific p53 mutant reactivation." Cancer cell.. 2012 May 15; 21(5):614-25.

2012
Tunceroglu A, Park JH, Balasubramanian S, Poppe M, Anker CJ, Poplin E, Moss RA, Yue NJ, Carpizo D, Gannon CJ, Haffty BG, Jabbour SK. "Dose-painted intensity modulated radiation therapy improves local control for locally advanced pancreas cancer." . 2012 2012:572342. Epub 2012 Oct 18.

9/2009
Carpizo DR, D'Angelica M. "Liver resection for metastatic colorectal cancer in the presence of extrahepatic disease." Annals of surgical oncology.. 2009 Sep 0; 16(9):2411-21. Epub 2009 Jun 25.

8/2009
Carpizo DR, Are C, Jarnagin W, Dematteo R, Fong Y, Gönen M, Blumgart L, D'Angelica M. "Liver resection for metastatic colorectal cancer in patients with concurrent extrahepatic disease: results in 127 patients treated at a single center." Annals of surgical oncology.. 2009 Aug 0; 16(8):2138-46. Epub 2009 Jun 03.

8/2009
Carpizo DR, D'Angelica M. "Liver resection for metastatic colorectal cancer in the presence of extrahepatic disease." The Lancet. Oncology.. 2009 Aug 0; 10(8):801-9.

4/2009
Rodríguez-Manzaneque JC, Carpizo D, Plaza-Calonge Mdel C, Torres-Collado AX, Thai SN, Simons M, Horowitz A, Iruela-Arispe ML. "Cleavage of syndecan-4 by ADAMTS1 provokes defects in adhesion." The international journal of biochemistry & cell biology.. 2009 Apr 0; 41(4):800-10. Epub 2008 Aug 15.

4/2009
Carpizo DR, D'Angelica M. "Management and extent of resection for intrahepatic cholangiocarcinoma." Surgical oncology clinics of North America.. 2009 Apr 0; 18(2):289-305, viii-ix.

10/2008
Carpizo DR, Allen PJ, Brennan MF. "Current management of cystic neoplasms of the pancreas." The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland.. 2008 Oct 0; 6(5):298-307.

5/23/2005
Lee S, Jilani SM, Nikolova GV, Carpizo D, Iruela-Arispe ML. "Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors." The Journal of cell biology.. 2005 May 23; 169(4):681-91.

6/27/2003
Luque A, Carpizo DR, Iruela-Arispe ML. "ADAMTS1/METH1 inhibits endothelial cell proliferation by direct binding and sequestration of VEGF165." The Journal of biological chemistry.. 2003 Jun 27; 278(26):23656-65. Epub 2003 Apr 25.

5/2003
Iruela-Arispe ML, Carpizo D, Luque A. "ADAMTS1: a matrix metalloprotease with angioinhibitory properties." Annals of the New York Academy of Sciences.. 2003 May 0; 995:183-90.

2000
Carpizo D, Iruela-Arispe ML. "Endogenous regulators of angiogenesis--emphasis on proteins with thrombospondin--type I motifs." Cancer metastasis reviews.. 2000 19(1-2):159-65.

2/1998
Carpizo DR, Reaka AJ, Glaws WR, Pooley N, Schmidt L, Halline AG, Goldstein JL, Layden TJ. "Acute acid exposure increases rabbit esophageal cell proliferation." The Journal of laboratory and clinical medicine.. 1998 Feb 0; 131(2):157-62.

Books & Chapters

2018
Book Title: Precision Molecular Pathology of Liver Cancer
Author List: Greco SH, Spencer K, Carpizo DR
Edited By: Chen Liu
Published By: Springer Publishing2018

2008
Book Title: : Metastatic Liver Cancer in Gastrointestinal Oncology: A Critical Multidisciplinary Team Approach.
Author List: Fong Y, Carpizo D, Kemeny NE, Covey AM, Willet CG, Czito BG
Edited By: Janusz Jankowski, Richard Sampliner, David Kerr, Yuman Fong
Published By: Blackwell Publishing2008

2004
Chapter Title: Brooks: Re-operative Breast Surgery
Book Title: Handbook of Re-operative General Surgery
Author List: Chang H, Carpizo, DR
Published By: Blackwell Publishing, Inc.2004 in Malden, MA