CONTACT INFORMATIONCREDENTIALSAWARDSPUBLICATIONSJing Wu, Ph.D.Contact InformationPhone NumbersOffice: (585) 275-5123Fax: (585) 276-1145LocationsUniversity of Rochester Medical CenterSchool of Medicine and Dentistry601 Elmwood Ave, Box 675Rochester, NY 14642Faculty AppointmentsAssistant Professor - Department of Medicine , Nephrology (SMD) Assistant Professor - Department of Pharmacology and Physiology (SMD) - JointBiographyResearchI was trained in vascular biology and immunology in hypertension research. My laboratory investigates the roles of PPARg (peroxisome proliferator activated receptor gamma), Cullin3 ubiquitin ligase, and their downstream signaling in renal physiology, immunobiology, and cardiometabolic diseases. Dominant negative mutations in PPARg (P467L, V290M, etc) and Cullin3 cause severe early onset hypertension in humans, while global PPARg activation reduces blood pressure in multiple clinical trials/studies. We and others have provided compelling evidence that the PPARg-Cullin3 axis regulates cardiovascular and renal physiology through actions in vascular and immune cells. My current K01 award (2021-2025) aims to understand the roles of vascular PPARg in renal physiology and salt sensitive hypertension. Using the inducible cre-loxP system, we created transgenic mice carrying human hypertension-causing mutations in PPARg selectively in vascular smooth muscle (S-P467L), which in response to salt loading develop impaired renal perfusion and enhanced sodium retention that ultimately leads to salt sensitive hypertension. These model systems are valuable tools to understand the renal hemodynamic mechanisms of salt sensitivity of blood pressure, the ability of the vascular-tubular interface to regulate renal electrolyte handling, and the vulnerability of these processes to genetic polymorphisms, oxidative stress, and inflammation. A second area of interest is to understand T cell PPARg and Cullin3 in hypertension and metabolic disorders. We have generated mouse models with genetic modifications in PPARg and Cullin3 selectively in T lymphocytes, which exhibit exaggerated hypertension, target organ damage, and altered adiposity/glucose homeostasis. The goal of this project is to elucidate immune mechanisms of hypertension and the ability of the immune cells to regulate the function of metabolic organs (pancreas, liver, adipose tissue). I am committed to promoting innovative, collaborative, inclusive academic research and to mentoring young members of the research team. My ultimate career goal is to apply our findings to translational research that may lead to the development of novel therapies for cardiovascular, renal, and metabolic diseases. Email Address: Jing_Wu@URMC.Rochester.edu Twitter Handle: @JingWu_URMCCredentialsEducation2009BMed | China-Peking UniversityPreventive Medicine2014PhD | Vanderbilt University School of MedicinePharmacologyAwards2021 - 2025K01 Research Scientist Development Award: Novel Mechanisms Regulating Renal Perfusion and Kidney Redox BiologySponsor: NIDDK K01 DK126792 Total: $721,4862021American Heart Association Council on Hypertension Stephanie Watts Career Development AwardSponsor: DataSci International: a radiotelemetry system ($50,000 value)2017 - 2019AHA AWRP Postdoctoral FellowshipSponsor: American Heart Association 17POST33660685 Total: $104,0602013 - 2014AHA Predoctoral FellowshipSponsor: AHA Greater Southeast Affiliate 13PRE14480008 Total: $50,360VIEW ALL expand_morePublicationsJournal Articles3/31/2022Fang S, Wu J, Reho JJ, Lu KT, Brozoski DT, Kumar G, Werthman AM, Silva SD, Muskus Veitia PC, Wackman KK, Mathison AJ, Teng BQ, Lin CW, Quelle FW, Sigmund CD. "RhoBTB1 reverses established arterial stiffness in angiotensin-II hypertension by promoting actin depolymerization." JCI insight.. 2022 Mar 31; Epub 2022 Mar 31. 1/2022Wu J, Sigmund CD. "Comorbidities Caused by a Corrupt Cullin 3: Lessons Learned From Bedside to Bench." Hypertension.. 2022 Jan 0; 79(1):76-78. Epub 2021 Dec 08. 2022Wu J, Fang S, Lu KT, Kumar G, Reho JJ, Brozoski DT, Otanwa AJ, Hu C, Nair AR, Wackman KK, Agbor LN, Grobe JL, Sigmund CD. "Endothelial Cullin3 Mutation Impairs Nitric Oxide-Mediated Vasodilation and Promotes Salt-Induced Hypertension." Function.. 2022 3(3):zqac017. Epub 2022 Apr 08. Books & Chapters2014 Chapter Title: Oxidative stress and hypertension Book Title: Blood Pressure and Arterial Wall Mechanics in Cardiovascular Diseases Author List: Wu J, Harrison DG Published By: Springer-Verlag 2014 in LondonVIEW ALL PUBLICATIONSClose WindowSchedule an appointment with Jing Wu, Ph.D.Please answer the following questions to help us find the right appointment for you.Important: If you believe that you have a medical or psychiatric emergency, please call 911 or go to the nearest hospital. This website is not intended for emergency care.Have you seen this provider in the last 2 years?YesNoExisting Patient Schedule or request a follow up appointment online through MyChart. If you do not have a MyChart account, please close this window and call the appointment phone number. Jing Wu, Ph.D. is currently scheduling for the following appointment type(s): Our policy does not permit patients to establish care with multiple providers within the same practice or specialty without prior approval. If you choose a new provider in the same office, we will cancel the appointment. Please contact the office directly with questions on this policy.