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Jing Wu, Ph.D.

Contact Information

Phone Numbers

Office: (585) 275-5123

Fax: (585) 276-1145

Faculty Appointments

Biography

Research

I was trained in vascular biology and immunology in hypertension research. My laboratory investigates the roles of PPARg (peroxisome proliferator activated receptor gamma), Cullin3 ubiquitin ligase, and their downstream signaling in renal physiology, immunobiology, and cardiometabolic diseases. Dominant negative mutations in PPARg (P467L, V290M, etc) and Cullin3 cause severe early onset hypertension in humans, while global PPARg activation reduces blood pressure in multiple clinical trials/studies. We and others have provided compelling evidence that the PPARg-Cullin3 axis regulates cardiovascular and renal physiology through actions in vascular and immune cells.

My current K01 award (2021-2025) aims to understand the roles of vascular PPARg in renal physiology and salt sensitive hypertension. Using the inducible cre-loxP system, we created transgenic mice carrying human hypertension-causing mutations in PPARg selectively in vascular smooth muscle (S-P467L), which in response to salt loading develop impaired renal perfusion and enhanced sodium retention that ultimately leads to salt sensitive hypertension. These model systems are valuable tools to understand the renal hemodynamic mechanisms of salt sensitivity of blood pressure, the ability of the vascular-tubular interface to regulate renal electrolyte handling, and the vulnerability of these processes to genetic polymorphisms, oxidative stress, and inflammation.

A second area of interest is to understand T cell PPARg and Cullin3 in hypertension and metabolic disorders. We have generated mouse models with genetic modifications in PPARg and Cullin3 selectively in T lymphocytes, which exhibit exaggerated hypertension, target organ damage, and altered adiposity/glucose homeostasis. The goal of this project is to elucidate immune mechanisms of hypertension and the ability of the immune cells to regulate the function of metabolic organs (pancreas, liver, adipose tissue).

I am committed to promoting innovative, collaborative, inclusive academic research and to mentoring young members of the research team. My ultimate career goal is to apply our findings to translational research that may lead to the development of novel therapies for cardiovascular, renal, and metabolic diseases.

Email Address: Jing_Wu@URMC.Rochester.edu
Twitter Handle: @JingWu_URMC

Credentials

Education

2009
BMed | China-Peking University
Preventive Medicine

2014
PhD | Vanderbilt University School of Medicine
Pharmacology

Awards

2022 - 2023
Role of PFAS in Hypertension and Chronic Kidney Disease
Sponsor: University of Rochester Environmental Health Science Center

2021 - 2025
K01 Research Scientist Development Award: Novel Mechanisms Regulating Renal Perfusion and Kidney Redox Biology
Sponsor: NIDDK K01 DK126792

2021
American Heart Association Council on Hypertension Stephanie Watts Career Development Award
Sponsor: DataSci International: a radiotelemetry system ($50,000 value)

2017 - 2019
AHA AWRP Postdoctoral Fellowship
Sponsor: American Heart Association 17POST33660685 Total: $104,060

2013 - 2014
AHA Predoctoral Fellowship
Sponsor: AHA Greater Southeast Affiliate 13PRE14480008 Total: $50,360

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Publications

Journal Articles

3/31/2022
Fang S, Wu J, Reho JJ, Lu KT, Brozoski DT, Kumar G, Werthman AM, Silva SD, Muskus Veitia PC, Wackman KK, Mathison AJ, Teng BQ, Lin CW, Quelle FW, Sigmund CD. "RhoBTB1 reverses established arterial stiffness in angiotensin-II hypertension by promoting actin depolymerization." JCI insight.. 2022 Mar 31; Epub 2022 Mar 31.

1/2022
Wu J, Sigmund CD. "Comorbidities Caused by a Corrupt Cullin 3: Lessons Learned From Bedside to Bench." Hypertension.. 2022 Jan; 79(1):76-78. Epub 2021 Dec 08.

2022
Wu J, Fang S, Lu KT, Kumar G, Reho JJ, Brozoski DT, Otanwa AJ, Hu C, Nair AR, Wackman KK, Agbor LN, Grobe JL, Sigmund CD. "Endothelial Cullin3 Mutation Impairs Nitric Oxide-Mediated Vasodilation and Promotes Salt-Induced Hypertension." Function.. 2022 3(3):zqac017. Epub 2022 Apr 08.

Books & Chapters

2014
Chapter Title: Oxidative stress and hypertension
Book Title: Blood Pressure and Arterial Wall Mechanics in Cardiovascular Diseases
Author List: Wu J, Harrison DG
Published By: Springer-Verlag 2014 in London

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