Jing Wu, Ph.D.

I am interested in mechanisms regulating redox balance and inflammation in renal-cardiovascular health and disease. Specifically, research in my laboratory emphasizes adaptive immunity, vascular-immune interface, gene-environmental interactions, and hemodynamics in the pathogenesis of hypertension and chronic kidney disease. The long-term research objectives are to understand the nature of autoregulation in the kidney, the ability of the renal circulation to regulate electrolyte transport, and the vulnerability of these processes to genetic mutations, oxidative stress and inflammation in hypertension and chronic kidney diseases.

Active projects include:
1. Novel Mechanisms Regulating Renal Perfusion and Kidney Redox Biology: Role in Salt Sensitive Hypertension (funded by a NIDDK K01, 2021-2025)
2. The Role of Cullin3 Ubiquitin Ligase in the Vascular-Immune Interface in Hypertension (funded by a University of Rochester Program for Advanced Immune Bioimaging Pilot Award)
3. Roles of Per- and Polyfluoroalkyl Substances (PFAS) in Hypertension and Chronic Kidney Disease (funded by a University of Rochester Environmental Health Science Center Pilot Award)

My research is continuously supported by extramural funding from the NIH and American Heart Association. Our original research has been published on JCI, JCI Insight, Circulation Research, Cardiovascular Research, Hypertension, and Function including multiple first-author and/or corresponding-author publications. With a dedication to professional service, I am an Associate Editor at Frontiers in Physiology (Sections of Vascular Physiology and Renal and Epithelial Physiology), and I am a chair on the organization committee for the ASN Basic Research Forum for Emerging Kidney Scientists. I also serve on the AHA Fellowship/IPA Study Sections.

I am committed to promoting innovative, collaborative, inclusive academic research and to mentoring young members of the research team. My ultimate career goal is to apply our findings to translational research that may lead to the development of novel therapies for cardiovascular, renal, and metabolic diseases.

Email Address: Jing_Wu@URMC.Rochester.edu
Twitter Handle: @JingWu_URMC