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Jing Wu, Ph.D.

Contact Information

Phone Numbers

Office: (585) 275-5123

Fax: (585) 276-1145

Faculty Appointments



I am interested in mechanisms regulating redox balance and inflammation in renal-cardiovascular health and disease. Specifically, research in my laboratory emphasizes adaptive immunity, vascular-immune interface, gene-environmental interactions, and hemodynamics in the pathogenesis of hypertension and chronic kidney disease. The long-term research objectives are to understand the nature of autoregulation in the kidney, the ability of the renal circulation to regulate electrolyte transport, and the vulnerability of these processes to genetic mutations, oxidative stress and inflammation in hypertension and chronic kidney diseases.

Active projects include:
1. Novel Mechanisms Regulating Renal Perfusion and Kidney Redox Biology: Role in Salt Sensitive Hypertension (funded by a NIDDK K01, 2021-2025)
2. The Role of Cullin3 Ubiquitin Ligase in the Vascular-Immune Interface in Hypertension (funded by a University of Rochester Program for Advanced Immune Bioimaging Pilot Award)
3. Roles of Per- and Polyfluoroalkyl Substances (PFAS) in Hypertension and Chronic Kidney Disease (funded by a University of Rochester Environmental Health Science Center Pilot Award)

My research is continuously supported by extramural funding from the NIH and American Heart Association. Our original research has been published on JCI, JCI Insight, Circulation Research, Cardiovascular Research, Hypertension, and Function including multiple first-author and/or corresponding-author publications. With a dedication to professional service, I am an Associate Editor at Frontiers in Physiology (Sections of Vascular Physiology and Renal and Epithelial Physiology), and I am a chair on the organization committee for the ASN Basic Research Forum for Emerging Kidney Scientists. I also serve on the AHA Fellowship/IPA Study Sections.

I am committed to promoting innovative, collaborative, inclusive academic research and to mentoring young members of the research team. My ultimate career goal is to apply our findings to translational research that may lead to the development of novel therapies for cardiovascular, renal, and metabolic diseases.

Email Address:
Twitter Handle: @JingWu_URMC



BMed | Peking University
Preventive Medicine

PhD | Vanderbilt University School of Medicine


2023 - 2023
URMC Bioimaging Pilot Award: The Vascular-Immune Interface: Role of Cullin3 Ubiquitin Ligase
Sponsor: NIH/NIAID P01AI102851 (Fowell, Kim, MPI)
Location: University of Rochester Program for Advanced Immune Bioimaging

2022 - 2023
EHSC Pilot Award: Role of PFAS in Hypertension and Chronic Kidney Disease
Sponsor: NIEHS P30ES001247 (PI: Paige Lawrence)
Location: University of Rochester Environmental Health Science Center

2021 - 2025
K01 Research Scientist Development Award: Novel Mechanisms Regulating Renal Perfusion and Kidney Redox Biology
Sponsor: NIDDK K01 DK126792

American Heart Association Council on Hypertension Stephanie Watts Career Development Award
Sponsor: DataSci International: a radiotelemetry system ($50,000 value)

2017 - 2019
AHA AWRP Postdoctoral Fellowship
Sponsor: American Heart Association 17POST33660685 Total: $104,060

2013 - 2014
AHA Predoctoral Fellowship
Sponsor: AHA Greater Southeast Affiliate 13PRE14480008 Total: $50,360

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Journal Articles

Fang S, Wu J, Reho JJ, Lu KT, Brozoski DT, Kumar G, Werthman AM, Silva SD, Muskus Veitia PC, Wackman KK, Mathison AJ, Teng BQ, Lin CW, Quelle FW, Sigmund CD. "RhoBTB1 reverses established arterial stiffness in angiotensin-II hypertension by promoting actin depolymerization." JCI insight.. 2022 Mar 31; Epub 2022 Mar 31.

Wu J, Sigmund CD. "Comorbidities Caused by a Corrupt Cullin 3: Lessons Learned From Bedside to Bench." Hypertension.. 2022 Jan; 79(1):76-78. Epub 2021 Dec 08.

Wu J, Fang S, Lu KT, Kumar G, Reho JJ, Brozoski DT, Otanwa AJ, Hu C, Nair AR, Wackman KK, Agbor LN, Grobe JL, Sigmund CD. "Endothelial Cullin3 Mutation Impairs Nitric Oxide-Mediated Vasodilation and Promotes Salt-Induced Hypertension." Function.. 2022 3(3):zqac017. Epub 2022 Apr 08.

Books & Chapters

Chapter Title: Oxidative stress and hypertension
Book Title: Blood Pressure and Arterial Wall Mechanics in Cardiovascular Diseases
Author List: Wu J, Harrison DG
Published By: Springer-Verlag 2014 in London