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Jack J. Chen, M.D., Ph.D.

Contact Information

Phone Numbers

Office: (585) 275-2803

Faculty Appointments



Dr. Chen's research interest is previously focused on gynecologic cancer molecular mechanisms of chemotherapy drug resistance, particularly in ovarian cancer. Among the gynecologic tumors, the incidence of cervical cancer has been dramatically decreased since Pap smear screening has been widely used. However, the endometrioid carcinoma incidence is recently found to be increasing and becoming an impending threat to women's health. More and more patients with even early stage or low-grade morphology disease are being found to be recurred earlier than expected or with metastatic disease. The pathologic morphology and the molecular categories are very broad in endometrioid carcinoma. Dr. Chen's recent study interest is on the mechanism study of sensitivity to hormone treatment and how to improve the efficacy of endometrioid adenocarcinoma to Mirena IUD hormone treatment.



MD, PhD | Shandong Medical University (China)

Post-doctoral Training & Residency

07/27/2021 - 07/26/2022
Fellowship in Breast & Gyn Pathology at University of Massachussets Memorial Medical Center

07/01/2020 - 06/30/2021
Fellowship in Oncological Surgical Pathology at Roswell Park Comprehensive Cancer Center

07/01/2016 - 06/30/2020
Residency in Pathology at Staten Island University Hospital, Northwell Health, NY

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True North Star Award
Sponsor: UMASS Memorial Medical Center, MA

Top reviewers for medicine
Sponsor: Web of Science


Journal Articles

Chen, J; Desouki, M. "Effect of PD-L1 expression and hypoxia on the clinical outcome of endometrioid adenocarcinoma treated with Mirena IUD." Human Pathology. 2022; .

Chen, J; Wu, R; Chen, JZ; Pabicon, V; Wrzolek, M; Simpkins, F; Simpkins, H. "2-Deoxyglucose mediates Dihydrodial Dehydrogenases overexpression and cisplatin resistance in human cervical cancer cells." American Journal of Biomedical and Life Sciences. 2019; 7(5): 110-120.

Chen, JZ; Wrzolek, M; Opitz,L; Chen, J. "A Mathematical Method to Easily and Accurately Measure the Tumor Volume of Prostate Cancer on Pathological Slides." International Journal Pathology and Clinical Research. 2019; 5(2): 101 (9 pages).