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Paper of the Week, The Journal of Biological Chemistry

Friday, October 11, 2013

A journal article by Kamil J. Alzayady, Larry E. Wagner II, Rahul Chandrasekhar, Alina Monteagudo, Ronald Godiska, Gregory G. Tall, Suresh K. Joseph, and David I. Yule was selected as a Paper of the Week by The Journal of Biological Chemistry.

Alzayady KJ, Wagner LE 2nd, Chandrasekhar R, Monteagudo AM, Godiska R, Tall GG, Joseph SK, and Yule DI. (2013) Functional inositol 1,4,5-trisphosphate receptors assembled from concatenated homo- and heteromeric subunits.J Biol Chem.288:29772-29784. (Paper of the Week)

Click here to view Kamil Alzayady's Author Profile.

Dirken Wins Convocation Award

Thursday, September 12, 2013

Dr. Robert T. Dirksen was selected as the 2013 recipient of the Excellence in Postdoctoral Mentoring Award. This award is presented to a postdoctoral mentor who shows dedication to postdoctoral trainees, as well as evidence of contributing significantly to their career development and professional advancement and was presented at the School of Medicine and Dentistry Convocation, September 12, 2013.

Hocking, Roy Image Selected as Cover Art for Tissue Engineering, Part B

Saturday, February 2, 2013

Cover Art for Tissue Engineering, Part B

An image by Dr. Denise C. Hocking and Dr. Daniel C. Roy was selected as cover art for Tissue Engineering, Part B: Reviews, Volume 19, Number 1, February 2013. The image consists of human mesenchymal stem cells adherent to a recombinant fibronectin mimetic substrate polymerize an endogenous fibronectin matrix (green) using α5β1 integrins (red).

Kammermeier Selected Councilor of UNYPS

Monday, May 14, 2012

Paul J. Kammermeier, Ph.D., was elected a Councilor of the Upstate New York Pharmacology Society at its Inaugural Annual Meeting, May 14, 2012, at the University at Buffalo.

“Couch Potato Pill” Might Stop Heat Stroke Too

Sunday, January 8, 2012

We’ve all seen the story in the news before. Whether it’s the death of a physically fit high school athlete at football training camp in August, or of an elderly woman gardening in the middle of the day in July, heat stroke is a serious, life-threatening condition for which there is no treatment beyond submersion in ice water or the application of ice packs to cool the body to a normal temperature.

But, in a new study published today in the journal Nature Medicine, scientists discovered what they believe is one of the first drugs to combat heat stroke. AICAR – an experimental therapy once dubbed the “couch potato pill” for its ability to mimic the effects of exercise in sedentary mice – protected animals genetically predisposed to the disorder and may hold promise for the treatment of people with enhanced susceptibility to heat-induced sudden death.

“There is a great need for the training staff of athletic teams, physicians in emergency rooms in places like Phoenix, and soldiers serving in the deserts of the Middle East to have a drug available to give to individuals during a heat stroke event,” said Robert T. Dirksen, Ph.D., study author and professor of Pharmacology and Physiology at the University of Rochester Medical Center. “Our study takes an important first step towards developing a new drug therapy that may be part of the standard treatment regimen for heat stroke in the future.”

The finding comes as heat stroke cases are on the rise. According to a recent study in the American Journal of Preventive Medicine, the number of heat-related injuries in the U.S. more than doubled from 1997 to 2006. In that 10-year period, an estimated 55,000 people were treated for the condition in emergency rooms across the country.

Read More: “Couch Potato Pill” Might Stop Heat Stroke Too