Deep Brain Stimulation Video

Deep brain stimulation (DBS), a therapy now being actively investigated for OCD, targets this circuit by placing the electrodes in the ventral anterior internal capsule and adjacent ventral striatum. Several ascending and descending fiber bundles pass through this site, each of which may differentially modulate these behaviors and, thus, the impact on OCD symptoms. A central hypothesis of this application is that DBS at this site, changes activity in fronto-basal ganglia circuits and therefore affects the balance between avoidance and reward-seeking behaviors; this balance underlies the therapeutic effects of DBS in OCD.