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Wakenda Tyler

TitleAssistant Professor
InstitutionSchool of Medicine and Dentistry
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 665
Rochester NY 14642
 Awards And Honors
1993 - 1994Scholar Athlete Award receipient in cross country, track and field  | Millersville University
2006     American Orthopaedic Association Future Leaders in Orthopaedics recipient  | American Orthopaedic Association
1997     The Fontes Health Professions Award in Pre-Med
2006     Joseph M. Lane, MD Resident Research Grant recipient
2000 - 2001Johns Hopkins School of Hygiene and Public Health Watt-Hansel Scholarship recipient  | Johns Hopkins School of Hygiene and Public Health
2002     Alpha Omega Alpha National Medical Honors Society Inductee
1996 - 1997Phi Kappa Phi Honors Society inductee  | Millersville University
1997     The Class of 1895 Award  | Millersville University
2002     Phi Beta Kappa Honors Society Inductee  | Johns Hopkins School of Hygiene and Public Health
1997     Summa Cum Laude, Department Honors and University Honors  | Millersville University
1997     The Cecil Upton Organic Chemistry Award
2001 - 2002Monumental City Medical Society Scholarship Recipient
Dr. Tyler's research interests overlap with her clinical practice and center around the treatment of patients with bone and soft tissue tumors and conditions that lead to osteolysis (bone destruction as a result of implant wear and loosening or presence of tumor). Her areas of on-going research at this time include:

1) Treatment of aggressive benign conditions, such as pigmented villonodular synovitis and giant cell tumor of bone. More specifically, the molecular and cellular signaling pathways of cells in these conditions and the genetic alterations that lead to such conditions.

2) Medical and surgical treatment of soft tissue sarcomas.

3) Inhibiting osteolysis in both benign and malignant bone conditions.

4) Allograft implantation for large bone defects.

5) Treatment of metastatic disease to bone from other organs systems.

 Selected Publications
List All   |   Timeline
  1. Tyler W, Bukata S, O'Keefe R. Atypical femur fractures. Clin Geriatr Med. 2014 May; 30(2):349-59.
    View in: PubMed
  2. Rahimi H, Wood R, Kuzin I, Tyler W, Dieudonne G, Kates S, Ritchlin CT, Schwarz EM. A127: validating popliteal lymph node phenotype and bin expansion as biomarkers of rheumatoid arthritis knee flare in clinical pilot studies. Arthritis Rheumatol. 2014 Mar; 66 Suppl 11:S166-7.
    View in: PubMed
  3. Dhillon RS, Xie C, Tyler W, Calvi LM, Awad HA, Zuscik MJ, O'Keefe RJ, Schwarz EM. PTH-enhanced structural allograft healing is associated with decreased angiopoietin-2-mediated arteriogenesis, mast cell accumulation, and fibrosis. J Bone Miner Res. 2013 Mar; 28(3):586-97.
    View in: PubMed
  4. Xie C, Schwarz EM, Sampson ER, Dhillon RS, Li D, O'Keefe RJ, Tyler W. Unique angiogenic and vasculogenic properties of renal cell carcinoma in a xenograft model of bone metastasis are associated with high levels of vegf-a and decreased ang-1 expression. J Orthop Res. 2012 Feb; 30(2):325-33.
    View in: PubMed
  5. Bukata SV, Digiovanni BF, Friedman SM, Hoyen H, Kates A, Kates SL, Mears SC, Mendelson DA, Serna FH, Sieber FE, Tyler WK. A guide to improving the care of patients with fragility fractures. Geriatr Orthop Surg Rehabil. 2011 Jan; 2(1):5-37.
    View in: PubMed
  6. Tyler WK, Healey JH, Morris CD, Boland PJ, O'Donnell RJ. Compress periprosthetic fractures: interface stability and ease of revision. Clin Orthop Relat Res. 2009 Nov; 467(11):2800-6.
    View in: PubMed
  7. DiResta GR, Manoso MW, Naqvi A, Zanzonico P, Smith-Jones P, Tyler W, Morris C, Healey JH. Bisphosphonate delivery to tubular bone allografts. Clin Orthop Relat Res. 2008 Aug; 466(8):1871-9.
    View in: PubMed
  8. Shindle MK, Tyler W, Edobor-Osula F, Gardner MJ, Shindle L, Toro J, Lane JM. Unsuspected lymphoma diagnosed with use of biopsy during kyphoplasty. J Bone Joint Surg Am. 2006 Dec; 88(12):2721-4.
    View in: PubMed
  9. Tyler WK, Vidal AF, Williams RJ, Healey JH. Pigmented villonodular synovitis. J Am Acad Orthop Surg. 2006 Jun; 14(6):376-85.
    View in: PubMed
  10. Domb BG, Tyler W, Ellis S, McCarthy E. Radiographic evaluation of pathological bone lesions: current spectrum of disease and approach to diagnosis. J Bone Joint Surg Am. 2004; 86-A Suppl 2:84-90.
    View in: PubMed
  11. Tyler W, Frassica FJ, McCarthy EF. Recurrence of a unicameral bone cyst after nineteen years. Orthopedics. 2002 Apr; 25(4):435-6.
    View in: PubMed
  12. Tyler W, McCarthy EF. Osteochondrosis of the superior pole of the patella: two cases with histologic correlation. Iowa Orthop J. 2002; 22:86-9.
    View in: PubMed
  13. Shadduck RK, Tyler WS, Porcellini A, Howard DE, Stohlman F. Stem cell response to alternate suppression and stimulation of the erythroid system. Radiat Res. 1972 May; 50(2):379-87.
    View in: PubMed


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