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Alin Vonica

TitleResearch Assistant Professor
InstitutionSchool of Medicine and Dentistry
DepartmentPathology and Laboratory Medicine
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 626
Rochester NY 14642
 Awards And Honors
2002 - 2005Ruth L Kirschstein National Research Service Award  | NICHD training grant
1997 - 2000Jack and Susan Rudin Scholar in the Biomedical Sciences
2006     Best Talk Prize  | Northeast Society for Developmental Biology
The salivary glands are important for their physiological role in digestion and oral health, and the site of pathological processes, from autoimmune diseases to cancer. I am using my experience in vertebrate embryology and signal transduction to understand the molecular processes underlying the development, maintenance, and regeneration of normal salivary glands, as well as their pathological alteration in oncogenesis.

 Selected Publications
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  1. Juneja SC, Vonica A, Zeiss C, Lezon-Geyda K, Yatsula B, Sell DR, Monnier VM, Lin S, Ardito T, Eyre D, Reynolds D, Yao Z, Awad HA, Yu H, Wilson M, Honnons S, Boyce BF, Xing L, Zhang Y, Perkins AS. Deletion of Mecom in mouse results in early-onset spinal deformity and osteopenia. Bone. 2014 Mar; 60:148-61.
    View in: PubMed
  2. Bates TJ, Vonica A, Heasman J, Brivanlou AH, Bell E. Coco regulates dorsoventral specification of germ layers via inhibition of TGFß signalling. Development. 2013 Oct; 140(20):4177-81.
    View in: PubMed
  3. Gao H, Chakraborty G, Lee-Lim AP, Mo Q, Decker M, Vonica A, Shen R, Brogi E, Brivanlou AH, Giancotti FG. The BMP inhibitor Coco reactivates breast cancer cells at lung metastatic sites. Cell. 2012 Aug 17; 150(4):764-79.
    View in: PubMed
  4. Warmflash A, Zhang Q, Sorre B, Vonica A, Siggia ED, Brivanlou AH. Dynamics of TGF-ß signaling reveal adaptive and pulsatile behaviors reflected in the nuclear localization of transcription factor Smad4. Proc Natl Acad Sci U S A. 2012 Jul 10; 109(28):E1947-56.
    View in: PubMed
  5. Vonica A, Rosa A, Arduini BL, Brivanlou AH. APOBEC2, a selective inhibitor of TGFß signaling, regulates left-right axis specification during early embryogenesis. Dev Biol. 2011 Feb 1; 350(1):13-23.
    View in: PubMed
  6. Shimomura Y, Agalliu D, Vonica A, Luria V, Wajid M, Baumer A, Belli S, Petukhova L, Schinzel A, Brivanlou AH, Barres BA, Christiano AM. APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex. Nature. 2010 Apr 15; 464(7291):1043-7.
    View in: PubMed
  7. Francois P, Vonica A, Brivanlou AH, Siggia ED. Scaling of BMP gradients in Xenopus embryos. Nature. 2009 Sep 3; 461(7260):E1; discussion E2.
    View in: PubMed
  8. Vonica A, Gumbiner BM. The Xenopus Nieuwkoop center and Spemann-Mangold organizer share molecular components and a requirement for maternal Wnt activity. Dev Biol. 2007 Dec 1; 312(1):90-102.
    View in: PubMed
  9. Vonica A, Brivanlou AH. The left-right axis is regulated by the interplay of Coco, Xnr1 and derrière in Xenopus embryos. Dev Biol. 2007 Mar 1; 303(1):281-94.
    View in: PubMed
  10. Vonica A, Brivanlou AH. An obligatory caravanserai stop on the silk road to neural induction: inhibition of BMP/GDF signaling. Semin Cell Dev Biol. 2006 Feb; 17(1):117-32.
    View in: PubMed
  11. Chamorro MN, Schwartz DR, Vonica A, Brivanlou AH, Cho KR, Varmus HE. FGF-20 and DKK1 are transcriptional targets of beta-catenin and FGF-20 is implicated in cancer and development. EMBO J. 2005 Jan 12; 24(1):73-84.
    View in: PubMed
  12. Bell E, Muñoz-Sanjuán I, Altmann CR, Vonica A, Brivanlou AH. Cell fate specification and competence by Coco, a maternal BMP, TGFbeta and Wnt inhibitor. Development. 2003 Apr; 130(7):1381-9.
    View in: PubMed
  13. Muñoz-Sanjuán I, Bell E, Altmann CR, Vonica A, Brivanlou AH. Gene profiling during neural induction in Xenopus laevis: regulation of BMP signaling by post-transcriptional mechanisms and TAB3, a novel TAK1-binding protein. Development. 2002 Dec; 129(23):5529-40.
    View in: PubMed
  14. Vonica A, Gumbiner BM. Zygotic Wnt activity is required for Brachyury expression in the early Xenopus laevis embryo. Dev Biol. 2002 Oct 1; 250(1):112-27.
    View in: PubMed
  15. Vonica A, Weng W, Gumbiner BM, Venuti JM. TCF is the nuclear effector of the beta-catenin signal that patterns the sea urchin animal-vegetal axis. Dev Biol. 2000 Jan 15; 217(2):230-43.
    View in: PubMed


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