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Elena Rustchenko-Bulgac Bulgac

TitleResearch Associate Professor
InstitutionSchool of Medicine and Dentistry
DepartmentBiochemistry and Biophysics
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 712
Rochester NY 14642
Chromosomes instability of human fungal pathogen Candida albicans. Survival due to specific chromosome rearrangements.

Candida albicans is a unicellular budding fungus that forms part of normal gut or genitalia microflora. In immunocompromized humans, however, C. albicans becomes an important opportunistic pathogen that can cause mortality. C. albicans is unique among other fungal pathogens by having an ability to infect divers sites of human body, including skin, nails, mucosal surfaces, as well as any other tissues or inner organs. In the laboratory, this fungus demonstrates an impressive ability to flourish under extreme pH and temperatures, as well as in other extreme environments. C. albicans possesses an acute ability to counter act the environmental stresses and to mount adequate phenotypic responses.

 Selected Publications
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  1. Ahmad A, Kravets A, Rustchenko E. Transcriptional regulatory circuitries in the human pathogen Candida albicans involving sense--antisense interactions. Genetics. 2012 Feb; 190(2):537-47.
    View in: PubMed
  2. Yang F, Yan TH, Rustchenko E, Gao PH, Wang Y, Yan L, Cao YY, Wang QJ, Ji H, Cao YB, Jiang YY. High-frequency genetic contents variations in clinical Candida albicans isolates. Biol Pharm Bull. 2011; 34(5):624-31.
    View in: PubMed
  3. Kravets A, Qin H, Ahmad A, Bethlendy G, Gao Q, Rustchenko E. Widespread occurrence of dosage compensation in Candida albicans. PLoS One. 2010; 5(6):e10856.
    View in: PubMed
  4. Rustchenko E. Chromosome instability in Candida albicans. FEMS Yeast Res. 2007 Jan; 7(1):2-11.
    View in: PubMed


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