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Jessica Shand

TitleAssistant Professor
InstitutionSchool of Medicine and Dentistry
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 777
Rochester NY 14642
 Awards And Honors
2009     Meg Colgan Award for Dedication to Underserved Children
2004 - 2006Howard Hughes Medical Institute Continuing Support Award
2012     American Society of Hematology Abstract Achievement Award
2006     Arnold P. Gold Foundation Humanism in Medicine Honor Society
2012     Honorable Mention, Fellows' Research Day
2011     American Society of Hematology Abstract Achievement Award
2008 - 2009American Society of Hematology Trainee Research Award
2008     Neonatal Intensive Care Unit Award
2014     St. Baldrick's Foundation Scholar, Principal Investigator
2014     American Society for Blood and Marrow Transplantation McCullough and Till Award for Best Basic Science
My research aims to identify mechanisms of immunologic resistance in acute lymphoblastic leukemia (ALL) that may lead to failure of either native immunosurveillance or cell-directed immunotherapy. This includes identifying key molecules in the marrow "niche", such as surface glycoproteins, that ALL uses to gain a selective survival advantage and that may be feasibly targeted.

 Selected Publications
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  1. Shand JC, Qin H, Nasholm N, Capitini CM, Fry TJ. Minor Antigen Distribution Predicts Site-Specific Graft-versus-Tumor Activity of Adoptively Transferred, Minor Antigen-Specific CD8 T Cells. Biol Blood Marrow Transplant. 2014 Jan; 20(1):26-36.
    View in: PubMed
  2. Shand JC, Jansson J, Hsu YC, Campbell A, Mullen CA. Differential gene expression in acute lymphoblastic leukemia cells surviving allogeneic transplant. Cancer Immunol Immunother. 2010 Nov; 59(11):1633-44.
    View in: PubMed
  3. Fry TJ, Shand JL, Milliron M, Tasian SK, Mackall CL. Antigen loading of DCs with irradiated apoptotic tumor cells induces improved anti-tumor immunity compared to other approaches. Cancer Immunol Immunother. 2009 Aug; 58(8):1257-64.
    View in: PubMed
  4. Shand JC, Mansky PJ, Brown MV, Fleisher TA, Mackall CL. Adolescents and young adults successfully restore lymphocyte homeostasis after intensive T-cell depleting therapy for cancer. Br J Haematol. 2006 Oct; 135(2):270-1.
    View in: PubMed
  5. Karl JC, Mackall CL. Cancer therapy-induced immune modulation. Cancer Chemother Biol Response Modif. 2005; 22:325-41.
    View in: PubMed


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