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Chin-Yi Chu

InstitutionSchool of Medicine and Dentistry
DepartmentPediatrics in the Center for Pediatric Biomedical Research
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 703
Rochester NY 14642
Infection with respiratory syncytial virus (RSV) can cause severe respiratory diseases in infants. My research goal is identify the genetic mechanisms of susceptibility to RSV infection. My current research focuses on discovering the genomic alterations within the immune system of the infants with RSV infection by analyzing the patients' data obtained from high throughput sequencing, particularly RNA-Seq. I am also interested in algorithm discovery and development for next generating sequencing data analysis.

 Selected Publications
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  1. Scapini P, Hu Y, Chu CL, Migone TS, Defranco AL, Cassatella MA, Lowell CA. Myeloid cells, BAFF, and IFN-gamma establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice. J Exp Med. 2010 Aug 2; 207(8):1757-73.
    View in: PubMed
  2. Chuang KH, Altuwaijri S, Li G, Lai JJ, Chu CY, Lai KP, Lin HY, Hsu JW, Keng P, Wu MC, Chang C. Neutropenia with impaired host defense against microbial infection in mice lacking androgen receptor. J Exp Med. 2009 May 11; 206(5):1181-99.
    View in: PubMed
  3. Viale A, Li J, Tiesman J, Hester S, Massimi A, Griffin C, Grills G, Khitrov G, Lilley K, Knudtson K, Ward B, Kornacker K, Chu CY, Auer H, Brooks AI. Big results from small samples: evaluation of amplification protocols for gene expression profiling. J Biomol Tech. 2007 Jul; 18(3):150-61.
    View in: PubMed
  4. Chuang KH, Lee YF, Lin WJ, Chu CY, Altuwaijri S, Wan YJ, Chang C. 9-cis-retinoic acid inhibits androgen receptor activity through activation of retinoid X receptor. Mol Endocrinol. 2005 May; 19(5):1200-12.
    View in: PubMed


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