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Nida Meednu

TitleResearch Assistant Professor
InstitutionSchool of Medicine and Dentistry
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 695
Rochester NY 14642
 Awards And Honors
1995 - 1998Development and Promotion of Science & Technology Scholarship
1997 - 1998Excellent in StudiesĀ  | Mahidol University
1999 - 2003Development and Promotion of Sceince & Technology Scholarship
Dr. Meednu's research focus is to understand the underlying pathogenic mechanisms of autoimmune diseases, speciffically systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), on the role of B cells in the development and progression of these diseases. She is investigating autoantibody independent functions of B cells including interaction with other immune cells and other relevant organ systems. In RA, Dr. Meednu is seeking to understand the mechanism of how B cells interact with osteoclasts and osteoblasts to contribute to bone erosion process in this disease.

 Selected Publications
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  1. Palanichamy A, Bauer JW, Yalavarthi S, Meednu N, Barnard J, Owen T, Cistrone C, Bird A, Rabinovich A, Nevarez S, Knight JS, Dedrick R, Rosenberg A, Wei C, Rangel-Moreno J, Liesveld J, Sanz I, Baechler E, Kaplan MJ, Anolik JH. Neutrophil-mediated IFN activation in the bone marrow alters B cell development in human and murine systemic lupus erythematosus. J Immunol. 2014 Feb 1; 192(3):906-18.
    View in: PubMed
  2. Block RC, Abdolahi A, Smith B, Meednu N, Thevenet-Morrison K, Cai X, Cui H, Mousa S, Brenna JT, Georas S. Effects of low-dose aspirin and fish oil on platelet function and NF-kappaB in adults with diabetes mellitus. Prostaglandins Leukot Essent Fatty Acids. 2013 Jul; 89(1):9-18.
    View in: PubMed
  3. Alonso A, D'Silva S, Rahman M, Meluh PB, Keeling J, Meednu N, Hoops HJ, Miller RK. The yeast homologue of the microtubule-associated protein Lis1 interacts with the sumoylation machinery and a SUMO-targeted ubiquitin ligase. Mol Biol Cell. 2012 Dec; 23(23):4552-66.
    View in: PubMed
  4. Block RC, Kakinami L, Jonovich M, Antonetti I, Lawrence P, Meednu N, CalderonArtero P, Mousa SA, Brenna JT, Georas S. The combination of EPA+DHA and low-dose aspirin ingestion reduces platelet function acutely whereas each alone may not in healthy humans. Prostaglandins Leukot Essent Fatty Acids. 2012 Oct-Nov; 87(4-5):143-51.
    View in: PubMed
  5. Emo J, Meednu N, Chapman TJ, Rezaee F, Balys M, Randall T, Rangasamy T, Georas SN. Lpa2 is a negative regulator of both dendritic cell activation and murine models of allergic lung inflammation. J Immunol. 2012 Apr 15; 188(8):3784-90.
    View in: PubMed
  6. Rezaee F, Meednu N, Emo JA, Saatian B, Chapman TJ, Naydenov NG, De Benedetto A, Beck LA, Ivanov AI, Georas SN. Polyinosinic:polycytidylic acid induces protein kinase D-dependent disassembly of apical junctions and barrier dysfunction in airway epithelial cells. J Allergy Clin Immunol. 2011 Dec; 128(6):1216-1224.e11.
    View in: PubMed
  7. Block RC, Duff R, Lawrence P, Kakinami L, Brenna JT, Shearer GC, Meednu N, Mousa S, Friedman A, Harris WS, Larson M, Georas S. The effects of EPA, DHA, and aspirin ingestion on plasma lysophospholipids and autotaxin. Prostaglandins Leukot Essent Fatty Acids. 2010 Feb-Mar; 82(2-3):87-95.
    View in: PubMed
  8. Roman J, Rangasamy T, Guo J, Sugunan S, Meednu N, Packirisamy G, Shimoda LA, Golding A, Semenza G, Georas SN. T-cell activation under hypoxic conditions enhances IFN-gamma secretion. Am J Respir Cell Mol Biol. 2010 Jan; 42(1):123-8.
    View in: PubMed
  9. Meednu N, Hoops H, D'Silva S, Pogorzala L, Wood S, Farkas D, Sorrentino M, Sia E, Meluh P, Miller RK. The spindle positioning protein Kar9p interacts with the sumoylation machinery in Saccharomyces cerevisiae. Genetics. 2008 Dec; 180(4):2033-55.
    View in: PubMed
  10. Phadnis N, Mehta R, Meednu N, Sia EA. Ntg1p, the base excision repair protein, generates mutagenic intermediates in yeast mitochondrial DNA. DNA Repair (Amst). 2006 Jul 13; 5(7):829-39.
    View in: PubMed


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