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Phagocytosis of cancer cells by macrophages. Live cell imaging over 1 hour (1 frame/second) using the FV1000 confocal microscope demonstrates the awesome ability of macrophages to engulf (and at times exocytose) cancer cells. Scale bar=20µm. Video courtesy of Karl VanDerMeid and Clive Zent. See also: Anti-CD20 monoclonal antibody-dependent phagocytosis of chronic lymphocytic leukaemia cells by autologous macrophages. Church AK, VanDerMeid KR, Baig NA, Baran AM, Witzig TE, Nowakowski GS, Zent CS. Clin Exp Immunol. 2016 Jan;183(1):90-101. doi: 10.1111/cei.12697. PMID: 26307241

TLR2 is expressed below tight junctions.  Spatial relationship between the tight junction protein, occludin (red), and the innate immune receptor, TLR2 (green), within the whole mount of adult human epidermis. Left Top Image: Reconstructed 3D maximum intensity Z-stack confocal image. Bottom Image: Slice by slice movie demonstrating the z positioning of each level projected in the upper image. Scale bar=40µm. Images courtesy of Takeshi Yoshida. See also: The cutaneous innate immune response in patients with atopic dermatitis. Kuo IH, Yoshida T, De Benedetto A, Beck LA. J Allergy Clin Immunol. 2013 Feb;131(2):266-78. doi: 10.1016/j.jaci.2012.12.1563. Review. PMID: 23374259.

Alpha-Bungarotoxin labeled muscle end plate. High magnification (200X) confocal maximum intensity projection of 488 conjugated Alpha-Bungarotoxin stained muscle end plate. Image courtesy of Paivi Jordan.