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Welcome to the Mouse Genome Editing Resource

Welcome to the Mouse Genome Editing (MGE) Resource at the University of Rochester Medical Center. This full-service core, formerly known as the Transgenic and Gene Targeting Resource Facility, is supported by the University of Rochester School of Medicine and Dentistry and is one of the Shared Resource Laboratories. The Core provides services in generating transgenic mice by pronuclear microinjection into zygotes, genetically engineered mice by gene targeting in embryonic stem cells (ESCs), and gene editing mouse models using CRISPR/Cas9 approach to all UR and external investigators in a timely and cost-effective manner. In addition, the Core provides services on preserving your valuable lines by cryopreservation of sperms and resurrecting mouse lines using in vitro fertilization (IVF) or embryo transfer. Additional services include rederivation to create pathogen-free mouse lines, developing molecular reagents for genetic engineering,full colony management services, and expert advice on mouse genetics and breeding schemes.

The Facility: The MGE Resource consists of two mouse rooms and a procedure room on the second floor of the School of Medicine Building and a wet lab for molecular biology and cell culture in the Flaum Eye Institute. The Core is fully equipped to carry out the entire procedure of generating mouse models as well as related services.

Executive Committee for Mouse Genome Editing Resource

The following faculty members have been invited to serve on the Executive Committee for this Shared Resource Laboratory:

  • Joe Miano, Ph.D., Professor, Aab Cardiovascular Research Institute 
  • Hartmut Land, Ph.D., Professor and Chair, Biomedical Genetics
  • Catherine Ovitt, Ph.D., Associate Professor, Center for Oral Biology
  • Eric Small, Ph.D., Assistant Professor, Aab Cardiovascular Research Institute
  • Charles Thornton, M.D., Professor, Neurology