A clinical trial is a research study involving human volunteers, and is designed to answer specific health questions. Carefully conducted clinical trials are the safest and fastest way to find effective treatments, and new ways to improve health.
You can search for all studies that are currently enrolling participants at the University of Rochester by typing in keywords in the search box below. If you don’t find a study that interests you right now, consider signing up for our Volunteer Registry, which will notify you of future studies.
Collecting Breast Milk Samples for Future Research
Lead Researcher: Kirsi Jarvinen-seppo
When some research ideas are initially formed, they need to be tested on small amounts
of human breast milk before moving on to large studies. This study will collect a
one-time breast milk sample and questionnaire from each participant for that purpose.
Participants will be compensated $5 per breast milk sample (up to 4 samples). Additionally,
this study will collect multiple breast milk samples from two different groups of
mothers who can collect samples at home. The first group will help us learn more about
food allergies by collecting samples before a meal and 1, 2, 6, and 24 hours after
a meal containing one egg, one cup of milk, or a small handful of peanuts. If a woman
is experiencing COVID-19 symptoms, they may join a different group that will provide
samples over time to help us learn how long the virus is present in breast milk.
View Study Details
Convalescent Plasma to Limit SARS-CoV-2 Associated Complications (CSSC-004)
Lead Researcher: Martin Zand
The purpose of this study is to is to determine if convalescent plasma will help a
person with COVID-19 symptoms improve and prevent admission into the hospital. Convalescent
plasma is plasma from a person who has recovered from a COVID-19 infection. Participants
in this study will receive either control or convalescent plasma. COVID-19 symptoms
include but are not limited to fever, cough, or loss of taste or smell. You must be
18 years or older to participate.
View Study Details
Convalescent Plasma to Stem Coronavirus in COVID negative participants (CSSC-001)
Lead Researcher: Martin Zand
This study will determine if plasma collected from the blood of people who have recovered
from COVID-19 infection will help others who are at risk for getting COVID-19. Participants
should be people who are at high risk for COVID-19 infection. They will receive a
one-time infusion of convalescent or control plasma. Convalescent plasma is from a
person who has recovered from a COVID-19 infection. Plasma will not have COVID-19
but will have antibodies to the virus. The purpose of this study is to determine
if these antibodies will help keep people who are at high risk for getting COVID from
getting infected. To be eligible you must have had close contact with someone who
is COVID-19 positive and have a high risk for illness such as >=65, reside in a nursing
home or long-term care facility, have chronic lung disease, asthma, heart disease,
obesity, uncontrolled diabetes, renal failure, liver disease or cancer. Or you must
be a healthcare professional with high risk exposure such as have had prolonged close
contact with patients with COVID-19 who were not wearing a facemask while HCP nose
and mouth were exposed to material potentially infectious with the virus causing COVID-19.
View Study Details
COVID-19 and Breastfeeding Mothers
Lead Researcher: Bridget Young
COVID-19 positive mothers:
We are seeking breastfeeding moms in the Rochester area - with a baby under 6 months
old - who have recently been diagnosed with COVID-19, ideally within the previous
7 days. The purpose of this study is to determine if there may be COVID-19 virus in
various samples we collect from mother and child. These samples include mother’s breast
milk, skin swab, saliva, and blood sample, as well as infant stool samples. These
will be taken within certain windows of time at your convenience inside the home.
Participation in this study will be for 90 days. You will be reimbursed a total of
$60 ($30 after day 10 collection and another $30 after the day 90 collection) via
check.
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Lactating mothers getting the COVID-19 vaccine:
We are seeking breastfeeding Moms in the Rochester area with infants of any age, who
will be getting the COVID-19 vaccine. We will be collecting a finger prick and small
breast milk sample from you at the following times: before you get the vaccine, 3-weeks
after your first dose, 3-weeks after your second dose, and 3 months after your final
dose (if you are still breastfeeding). You collect all samples inside your home.
Participation in this study will be for about 90 days. You will be reimbursed a total
of $50 via check.
View Study Details
COVID-19 Vaccine Studies
Lead Researcher: Ann Falsey
URMC is studying several variations of a COVID-19 vaccine. Compensation: $500-$900.
Participation Requirements: Age 18+; Have not been infected with COVID-19. To volunteer,
take our survey to find out if you qualify: https://redcap.urmc.rochester.edu/redcap/surveys/?s=XHH9MC8RMK
View Study Details
Describing the Infection/Illness Mechanisms for Influenza and COVID-19
Lead Researcher: Angela Branche
This study will obtain timed samples of blood and nasal secretions from adults, children,
and the elderly with influenza-like illness. It will look to characterize the pathogenesis
(mechanisms of infection/illness) and the responses that occur within the immune system
- for both COVID-19 and influenza.
View Study Details
Parent and Children Conversations about COVID-19
Lead Researcher: Karl Rosengren
This is a study that will examine conversations parents are having with their children
with respect to the situation caused by COVID-19. Furthermore, we will examine how
stress related to the pandemic influences family dynamics. Rochester area parents
with at least one child ages 3-7 may be eligible to complete this survey. Participants
will fill out a 35-minute online survey. Participants that complete the survey will
be eligible to win a $25 gift card.
View Study Details
Pediatric Acute Kidney Injury in COVID-19
Lead Researcher: Susan Martin
This study is an observational registry of children with or suspected to have SARS
CoV2
(COVID-19) admitted to pediatric intensive care units (PICU). This registry will help
describe the prevalence, rate and severity of acute kidney injury (AKI) in children
with
Severe Acute Respiratory Syndrome Coronavirus-2(SARS CoV2) across the world. The registry
will be developed using a point prevalence methodology and then full retrospective
review.
Once a week, from April through June 2020, data collection will occur in "real-time"
to
estimate a weekly point prevalence of AKI and renal replacement therapy (RRT). The
operational definition of "patients under investigation" (PUIs) will be used to identify
the
denominator of patients to be studied. The PUIs will be cohorted into SARS CoV2 test
positive, test negative, test pending, or test unavailable. The primary aim of this
study is
to deliver a global, objective data driven analysis of the burden of AKI in virus
positive
patients or patients under investigation (PUI) who are admitted to the pediatric intensive
care unit.
View Study Details