Skip to main content
Explore URMC


Rectal Cancer: Trial Evaluating 3-year Disease Free Survival in Patients With Locally Advanced Rectal Cancer Treated With Chemoradiation Plus Induction or Consolidation Chemotherapy and Total Mesorectal Excision or Non-operative Management

Research Question:
Is it better to have extra chemotherapy before surgery or after initial chemo-radiation and surgery?

Basic Study Information

Patients with rectal cancer are given chemotherapy and radiation therapy, and then they have surgery to remove the rectum. Chemotherapy and radiation therapy are given at the same time. This is called chemoradiation. Sometimes after surgery, patients will have extra chemotherapy without radiation. The extra chemotherapy is given to help make sure the tumor does not come back and to try and cure patients of their cancer. The purpose of this study is to increase the number of patients cured from their rectal cancer by giving the extra chemotherapy before surgery instead of after surgery. We also want to find out what effects, good and/or bad, having chemotherapy before surgery has on you and your rectal cancer. We believe that it will be better for you to have chemotherapy before surgery, but we are not sure if it is better to give the chemotherapy before or after the chemoradiation. Another important purpose of this study is to try and avoid surgery in patients with rectal tumors that have disappeared in response to the chemoradiation and the chemotherapy given before surgery. We believe that having additional chemotherapy before surgery may improve the chances that your tumor will disappear and we will be able to save your rectum.

Location: Cancer center
Study Web URL:
Study Reference #: UGIC-14047

Lead Researcher (Principal Investigator)

Lead Researcher: Mohamedtaki Tejani, MD

Study Contact Information

Study Coordinator: Tanya Smith
Phone: (585) 275-8213

Additional Study Details

Return to Search