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Safety of Sildenafil in Premature Infants

Research Question:
Is the drug Sildenafil safe and effective when given to premature infants who have bronchopulmonary dysplasia?

Basic Study Information

Purpose:
Bronchopulmonary dysplasia (BPD) is a form of chronic lung disease that affects newborns (mostly premature) and infants. It results from damage to the lungs caused by mechanical ventilation (respirator) and long-term use of oxygen. Most infants recover from BPD, but some may have long-term breathing difficulty. This study will look at the safety of sildenafil in premature infants at risk of bronchopulmonary dysplasia and determine preliminary effectiveness and pharmacokinetics (PK) of sildenafil. Funding Source - FDA OOPD.

Location: Golisano Children's Hospital - University of Rochester Medical Center

Study Contact Information

Study Coordinator: Matthew M Laughon, MD, MPH
Phone: (984) 974-7851
Email: matt_laughon@med.unc.edu

Additional Study Details

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