Observational Study of ICU Patients with Systemic Inflammatory Response Syndrome (SIRS)
Do patients with different causes of severe Systemic Inflammatory Response Syndrome (SIRS) have similar or different severity of illness and recovery rates? What are the biological similarities and differences between patients with severe SIRS caused by different illnesses? Will the biological tests we do in this study help us to predict how sick patients will become and how their health will be after the severe SIRS is over?
Lead Researcher: Anthony Pietropaoli
This is an observational research study of subjects admitted to the ICU with severe SIRS (and/or sepsis). For ICU subjects enrolled: the study involves collecting up to 2 blood samples (3-5 days apart), data collection, and post-discharge follow-up questionnaires. For healthy volunteers: Subjects age 65 and older are needed for a one-time blood sample collection for comparison studies. A brief health questionnaire and set of vital signs will also be collected at the study visit. Volunteers must be age 65 or older and cannot be on antibiotics or antivirals for current infection. Volunteers also must not have had an infection within 6 weeks prior to the study visit.
Eligibility:
Eligible ICU study subjects may be recruited if they meet severe SIRS criteria & are evaluated my the MICU team. We are looking for HEALTHY VOLUNTEERS who are: *age 65 or older *not on antibiotics *without an active infection or recent infection (within the last 6 weeks) *not in chronic severe kidney or liver failure *not pregnant *have not had a transplant *do not have severe anemia or other blood disorder