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URMC / The RoAR Center / Notable Publications
 

Notable Publications

Tian X, Azpurua J, Ke Z, Augereau A, Zhang ZD, Vijg J, Gladyshev VN, Gorbunova V, Seluanov A. (2014) INK4 locus of the tumor-resistant rodent, the naked mole rat, expresses a functional p15/p16 hybrid isoform. Proc. Natl. Acad. Sci. USA, pii: 201418203. [Epub ahead of print]

Gorbunova V, Boeke JD, Helfand SL, Sedivy JM. (2014) Human Genomics. Sleeping dogs of the genome. Science, 346(6214):1187-8. No abstract available.

Van Meter M, Kashyap M, Rezazadeh S, Geneva AJ, Morello TD, Seluanov A, Gorbunova V. (2014) SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age. Nat Commun, 5:5011.

Xiao T., Azpurua J., Hine C., Mao Z., Rempel M., Gorbunova V., and Seluanov A. (2013) High molecular weight hyaluronan mediates cancer resistance of the naked mole rat. Nature, 499(7458):346-9. This study deciphered a molecular mechanism of naked mole rat's remarkable resistance to cancer.

Rahman, M.M., Sykiotis, G.P. & Bohmann, D. (2013) Declining signal-dependence of Nrf2-MafS regulated gene expression correlates with aging phenotypes. Aging Cell, 12, 554-62.

Mao Z., Tian X., VanMeter M., Ke Z., Gorbunova V., and Seluanov A. (2012) Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence. Proc. Natl. Acad. Sci. USA, 109(29):11800-5. This paper showed that inducing the longevity gene SIRT6 rescues senescence-related decline in DNA repair.

Gorbunova V, Hine C, Tian X, Ablaeva J, Gudkov AV, Nevo E, Seluanov A. (2012) Cancer resistance in the blind mole rat is mediated by concerted necrotic cell death mechanism. Proc Natl Acad Sci USA. 109(47):19392-6. In this paper scientists discovered a novel anticancer mechanism in the long-lived rodent, the blind mole rat.

Chatterjee, N. & Bohmann, D. (2012) A versatile ΦC31 based reporter system for measuring AP‑1 and Nrf2 signaling in Drosophila and in tissue culture. PLoS ONE, 7(4): e34063

Mao Z., Hine C., VanMeter M., Tian X., Vaidya A., Seluanov A. and Gorbunova V. (2011) SIRT6 promotes DNA repair under stress by activating PARP1. Science, 332(6036): 1443-6. Comment in: Sirtuin 6 and DNA Repair, Guy Riddihough, Science Signaling 21 June 2011: ec177. This paper demonstrated that the longevity gene SIRT6 facilitates DNA repair under stress.

Hochmuth, C., Biteau, B., Bohmann, D. & Jasper, H (2011) Redox regulation by Keap1 and Nrf2 controls intestinal stem cell proliferation in Drosophila. Cell Stem Cell, 8, 188-199.

Barone, M.C., Sykiotis, G.P. & Bohmann, D. (2011) Genetic activation of Nrf2 signaling is sufficient to ameliorate neurodegenerative phenotypes in a Drosophila model of Parkinson’s disease. Disease Models and Mechanisms, 4, 701-707.

Sykiotis, G.P. & Bohmann, D. (2010) Stress-activated cap’n’collar transcription factors in aging and human disease. Science Signaling, 3(112): re3.

Seluanov A., Hine C., Azpurua J., Feigenson M., Mao Z., Catania K.C., and Gorbunova V. (2009) Hypersensitivity to contact inhibition provides a clue to cancer resistance of naked mole-rat. Proc. Natl. Acad. Sci, USA, 106(46):19352-7. This paper provides the first clues to the mechanisms responsible for extraordinary cancer resistance of naked mole rats. This paper was awarded PNAS Cozzarelli Prize for outstanding scientific excellence and originality.

Seluanov A., Hine C., Bozzella M., Hall A., Sasahara T.H.C., Ribeiro A.A.C.M., Catania K.C., Presgraves D.C., and Gorbunova V. (2008) Distinct tumor suppressor mechanisms evolve in rodent species that differ in size and lifespan. Aging Cell, 7(6):813-23. This paper identified rules that control evolution of tumor suppressors depending on lifespan and body mass.

Sykiotis, G.P. & Bohmann, D. (2008) Keap1/Nrf2 signaling regulates oxidative stress tolerance and lifespan in Drosophila. Developmental Cell, 14, 76-85.

Seluanov A., Chen Z., Hine C., Sasahara T.H.C., Ribeiro A.A.C.M., Catania K.C., Presgraves D.C., and Gorbunova V. (2007) Telomerase activity coevolves with body mass not lifespan. Aging Cell, 6(1):45-52. This is the first publication where we employed a collection of short-and long-lived rodent species to identify mechanisms of longevity. This paper demonstrated that repression of telomerase activity evolved as anticancer mechanism in large animals.

Wang, M.C., Bohmann, D. & Jasper, H. (2005) JNK extends lifespan and limits growth by antagonizing cellular and organism-wide responses to insulin signaling. Cell, 121, 115-125.