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Part IV: Preparing the Next Wave

Part IV: Preparing the Next Wave

As years of dedication to her research is catapulting RNA biologist Lynne Maquat into the scientific spotlight, she remains intently focused on training and encouraging the next wave of scientists to even greater heights. She’s quick to acknowledge that her success wouldn’t be possible without the graduate students and post-docs who worked with her over almost four decades, and continues to be intimately involved in the science and day-to-day happenings in her lab.

Part III: The Power and Promise of RNA

Part III: The Power and Promise of RNA

RNA presents an entirely new pool of drugs targets and provides an opening to correct diseases that don’t respond to conventional drugs. Lynne Maquat is working to gain a deeper understanding of RNA and the sophisticated mechanisms related to nonsense-mediated mRNA decay.

Part II: Making Sense of Nonsense

Part II: Making Sense of Nonsense

As in most areas of life, mistakes in cells happen all the time. Luckily, the human body has built-in systems to eliminate potentially harmful slip-ups. Nonsense-mediated mRNA decay (NMD) is one of those systems, but before RNA biologist Lynne Maquat came on the scene, no one could come up with a logical explanation for how it worked. At a time when many scientists abandoned ship, Maquat stuck with it, and slowly made significant advances.

Part I: Lynne Maquat’s 40-Year-Voyage to Solve the Mysteries of Gene Expression

Part I: Lynne Maquat’s 40-Year-Voyage to Solve the Mysteries of Gene Expression

Years of meticulous focus led to Lynne Maquat’s discovery of nonsense-mediated mRNA decay (NMD), one of the most prominent surveillance systems in the body to protect against mistakes in gene expression that lead to disease. Poised on one of the newest and most promising frontiers of discovery, her work in the burgeoning field of RNA biology may one day help to cure nearly every disease on the planet.