Welcome to the Gene Targeting and Transgenic Core

Welcome to the Transgenic and Gene Targeting Core Facility at the University of Rochester Medical Center.This full-service core is supported by the University of Rochester School of Medicine and Dentistry and is one of The Shared Resource Laboratories. The Core provides services in generating transgenic mice by pronuclear microinjection into zygotes, genetically engineered mice by gene targeting in embryonic stem cells (ESCs), and gene editing mouse models usingCRISPR/Cas9 approach to all UR as well as external investigators in a timely and cost-effective manner. In addition, the Core provides services on preserving your valuable lines by cryopreservation of sperms and to resurrecting mouse lines using in vitro fertilization (IVF) or embryo transfer. Additional services include rederivation to createpathogen-free mouse lines, developing molecular reagents for genetic engineering,full colony management services, and expertadvice on mouse genetics and breeding schemes.

The Facility - The Core consists of two mouse rooms and a procedure room on the second floor of the School of Medicine Building and a wet lab for molecular biology and cell culture in the Flaum Eye Institute. The Core is fully equipped to carry out the entire procedure of generating mouse models as well as related services.


Our Mission

The mission of the Gene Targeting and Transgenic Core is to provide expertise and assistance in the development and production of genetically engineered animal models of human disease, in a timely and cost-effective manner.

Executive Committee for Transgenic Resource Laboratory

The following faculty members have been invited to serve on the Executive Committee for this Shared Resource Laboratory:

  • Joe Miano, Ph.D., Associate Professor, Aab Cardiovascular Research Institute 
  • Hartmut Land, Ph.D., Professor and Chair, Biomedical Genetics
  • Catherine Ovitt, Ph.D., Associate Professor, Center for Oral Biology
  • Eric Small, Ph.D., Assistant Professor, Aab Cardiovascular Research Institute 
  • Charles Thornton, M.D., Professor, Neurology

CRISPR is here!

We are beginning to offer CRISPR services in our facility. Learn more about the CRISPR technology here!

Contact Information

Lin Gan, Ph.D.
Professor of Ophthalmology
Office: Room 1-3005, Flaum Eye Institute, Box 314
Phone: (585) 273-1510

Lab Contact

Xiaoling Xie
Lab: Room 1-3022, Flaum Eye Institute
Phone: (585) 273-1513