Neuroendocrine Prostate Introduction The Genitourinary Pathology Section (GUPS) at the UR Medicine has a special interest in the neuroendocrine prostate. It is our hypothesis that the neuroendocrine cell plays a critical role in both the normal functioning of the prostate and the progression of prostate cancer. Dr. P. Anthony di Sant'Agnese has a long-standing research interest in the role of the prostatic neuroendocrine cell and neuroendocrine differentiation in prostate cancer. Past studies include seminal descriptive morphologic investigations as well as clinical-pathological correlative studies. His group was the first to describe several peptide hormone products of prostatic neuroendocrine cells as well as the ultrastructural morphology of neuroendocrine cell types. More recent research has focused on in vitro and in vivo investigations of regulatory mechanisms and phenotypic effects of prostatic neuroendocrine differentiation in cell lines and mouse models. GUPS is also involved in the Clinical and Research operations of the UR Medicine Immunocytochemistry Laboratory.