Recent Publications

• 1. Rook ML
  2. McCullock TW
  3. Couch T
  4. Lueck JD
  5. MacLean DM
  Photomodulation of the ASIC1a acidic pocket destabilizes the open state.; Protein science : a publication of the Protein Society. 2023 Jan 08.
• 1. Allen JP
  2. Garber KB
  3. Perszyk R
  4. Khayat CT
  5. Kell SA
  6. Kaneko M
  7. Quindipan C
  8. Saitta S
  9. Ladda RL
  10. Hewson S
  11. Inbar-Feigenberg M
  12. Prasad C
  13. Prasad AN
  14. Olewiler L
  15. Mu W
  16. Rosenthal LS
  17. Scala M
  18. Striano P
  19. Zara F
  20. McCullock TW
  21. Jauss RT
  22. Lemke JR
  23. MacLean DM
  24. Zhu C
  25. Yuan H
  26. Myers SJ
  27. Traynelis SF
  Clinical features, functional consequences, and rescue pharmacology of missense GRID1 and GRID2 human variants.; Human molecular genetics. 2023 Jan 07.
• 1. Rook ML
  2. Miaro M
  3. Couch T
  4. Kneisley DL
  5. Musgaard M
  6. MacLean DM
  Mutation of a conserved glutamine residue does not abolish desensitization of acid-sensing ion channel 1.; The Journal of general physiology; Vol 153(8). 2021 Aug 02.
• 1. Couch T
  2. Berger K
  3. Kneisley DL
  4. McCullock TW
  5. Kammermeier P
  6. Maclean DM
  Topography and motion of the acid-sensing ion channel intracellular domains.; eLife; Vol 10. 2021 Jul 22.
• 1. Rook ML
  2. Ananchenko A
  3. Musgaard M
  4. MacLean DM
  Molecular Investigation of Chicken Acid-Sensing Ion Channel 1 β11-12 Linker Isomerization and Channel Kinetics.; Frontiers in cellular neuroscience; Vol 15. 2021.
• 1. Rook ML
  2. Musgaard M
  3. MacLean DM
  Coupling structure with function in acid-sensing ion channels: challenges in pursuit of proton sensors.; The Journal of physiology. 2020 Apr 19.
• 1. Durham RJ
  2. Paudyal N
  3. Carrillo E
  4. Bhatia NK
  5. Maclean DM
  6. Berka V
  7. Dolino DM
  8. Gorfe AA
  9. Jayaraman V
  Conformational spread and dynamics in allostery of NMDA receptors.; Proceedings of the National Academy of Sciences of the United States of America; Vol 117(7). 2020 Feb 18.
• 1. Rook ML
  2. Williamson A
  3. Lueck JD
  4. Musgaard M
  5. Maclean DM
  β11-12 linker isomerization governs acid-sensing ion channel desensitization and recovery.; eLife; Vol 9. 2020 Feb 07.
• 1. Carrillo E
  2. Shaikh SA
  3. Berka V
  4. Durham RJ
  5. Litwin DB
  6. Lee G
  7. MacLean DM
  8. Nowak LM
  9. Jayaraman V
  Mechanism of modulation of AMPA receptors by TARP-γ8.; The Journal of general physiology; Vol 152(1). 2020 Jan 06.
• 1. McCullock TW
  2. MacLean DM
  3. Kammermeier PJ
  Comparing the performance of mScarlet-I, mRuby3, and mCherry as FRET acceptors for mNeonGreen.; PloS one; Vol 15(2). 2020.
• 1. MacLean DM
  2. Durham RJ
  3. Jayaraman V
  Mapping the Conformational Landscape of Glutamate Receptors Using Single Molecule FRET.; Trends in neurosciences; Vol 42(2). 2019 Feb.
• 1. Chen J
  2. Li L
  3. Chen SR
  4. Chen H
  5. Xie JD
  6. Sirrieh RE
  7. MacLean DM
  8. Zhang Y
  9. Zhou MH
  10. Jayaraman V
  11. Pan HL
  The α2δ-1-NMDA Receptor Complex Is Critically Involved in Neuropathic Pain Development and Gabapentin Therapeutic Actions.; Cell reports; Vol 22(9). 2018 Feb 27.
• 1. Dolino DM
  2. Chatterjee S
  3. MacLean DM
  4. Flatebo C
  5. Bishop LDC
  6. Shaikh SA
  7. Landes CF
  8. Jayaraman V
  The structure-energy landscape of NMDA receptor gating.; Nature chemical biology. 2017 Oct 09.
• 1. Coombs ID
  2. MacLean DM
  3. Jayaraman V
  4. Farrant M
  5. Cull-Candy SG
  Dual Effects of TARP γ-2 on Glutamate Efficacy Can Account for AMPA Receptor Autoinactivation.; Cell reports; Vol 20(5). 2017 Aug 01.
• 1. MacLean DM
  2. Jayaraman V
  Deactivation kinetics of acid-sensing ion channel 1a are strongly pH-sensitive.; Proceedings of the National Academy of Sciences of the United States of America; Vol 114(12). 2017 Mar 21.
• 1. Vitrac H
  2. MacLean DM
  3. Karlstaedt A
  4. Taegtmeyer H
  5. Jayaraman V
  6. Bogdanov M
  7. Dowhan W
  Dynamic Lipid-dependent Modulation of Protein Topology by Post-translational Phosphorylation.; The Journal of biological chemistry; Vol 292(5). 2017 Feb 03.
• 1. Shaikh SA
  2. Dolino DM
  3. Lee G
  4. Chatterjee S
  5. MacLean DM
  6. Flatebo C
  7. Landes CF
  8. Jayaraman V
  Stargazin Modulation of AMPA Receptors.; Cell reports; Vol 17(2). 2016 Oct 04.
• 1. MacLean DM
  2. Jayaraman V
  Acid-sensing ion channels are tuned to follow high-frequency stimuli.; The Journal of physiology; Vol 594(10). 2016 May 15.
• 1. Vitrac H
  2. MacLean DM
  3. Jayaraman V
  4. Bogdanov M
  5. Dowhan W
  Dynamic membrane protein topological switching upon changes in phospholipid environment.; Proceedings of the National Academy of Sciences of the United States of America; Vol 112(45). 2015 Nov 10.
• 1. Sirrieh RE
  2. MacLean DM
  3. Jayaraman V
  A conserved structural mechanism of NMDA receptor inhibition: A comparison of ifenprodil and zinc.; The Journal of general physiology; Vol 146(2). 2015 Aug.
• 1. Sirrieh RE
  2. MacLean DM
  3. Jayaraman V
  Subtype-dependent N-methyl-D-aspartate receptor amino-terminal domain conformations and modulation by spermine.; The Journal of biological chemistry; Vol 290(20). 2015 May 15.
• 1. MacLean DM
  2. Ramaswamy SS
  3. Du M
  4. Howe JR
  5. Jayaraman V
  Stargazin promotes closure of the AMPA receptor ligand-binding domain.; The Journal of general physiology; Vol 144(6). 2014 Dec.
• 1. Lee G
  2. MacLean DM
  3. Ulrich H
  4. Zhao X
  5. Aronowski J
  6. Jayaraman V
  RNA based antagonist of NMDA receptors.; ACS chemical neuroscience; Vol 5(7). 2014 Jul 16.
• 1. Ramaswamy SS
  2. MacLean DM
  3. Gorfe AA
  4. Jayaraman V
  Proton-mediated conformational changes in an acid-sensing ion channel.; The Journal of biological chemistry; Vol 288(50). 2013 Dec 13.
• 1. Sirrieh RE
  2. MacLean DM
  3. Jayaraman V
  Amino-terminal domain tetramer organization and structural effects of zinc binding in the N-methyl-D-aspartate (NMDA) receptor.; The Journal of biological chemistry; Vol 288(31). 2013 Aug 02.
• 1. MacLean DM
  CrossTalk opposing view: TARPs modulate AMPA receptor conformations before the gating transitions.; The Journal of physiology; Vol 591(7). 2013 Apr 01.
• 1. Ramaswamy S
  2. Cooper D
  3. Poddar N
  4. MacLean DM
  5. Rambhadran A
  6. Taylor JN
  7. Uhm H
  8. Landes CF
  9. Jayaraman V
  Role of conformational dynamics in α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor partial agonism.; The Journal of biological chemistry; Vol 287(52). 2012 Dec 21.
• 1. Maclean DM
  2. Bowie D
  Transmembrane AMPA receptor regulatory protein regulation of competitive antagonism: a problem of interpretation.; The Journal of physiology; Vol 589(Pt 22). 2011 Nov 15.
• 1. Maclean DM
  2. Wong AY
  3. Fay AM
  4. Bowie D
  Cations but not anions regulate the responsiveness of kainate receptors.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 31(6). 2011 Feb 09.
• 1. MacLean DM
  The delta2 glutamate-like receptor undergoes similar conformational changes as other ionotropic glutamate receptors.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 29(21). 2009 May 27.
• 1. Wong AY
  2. MacLean DM
  3. Bowie D
  Na+/Cl- dipole couples agonist binding to kainate receptor activation.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 27(25). 2007 Jun 20.
• 1. Kuang D
  2. Yao Y
  3. Maclean D
  4. Wang M
  5. Hampson DR
  6. Chang BS
  Ancestral reconstruction of the ligand-binding pocket of Family C G protein-coupled receptors.; Proceedings of the National Academy of Sciences of the United States of America; Vol 103(38). 2006 Sep 19.