Research
Goals
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AR role in diseases
To clarify the molecular mechanisms of androgen action through
the androgen receptor. To clarify the roles of androgen/AR in
organ development and AR-related disease. To dissect the involvement
of AR coregulators in AR function and their roles in AR-related
diseases.
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ARŐs physiological functions
Androgen receptor has a broad expression pattern involving
many tissues and organs. By using a cre-lox conditional knockout
strategy, ARKO mice have been generated in our laboratory. We
provide a useful in vivo model to study the role of AR in bone,
breast, immunity, and the female and male reproductive systems.
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Vitamin D anti-cancer effects
Investigation of the molecular mechanism of the anti-proliferative
and anti-invasiveness effects of vitamin D in prostate cancer.
Evaluation of the effects of cytotoxic chemotherapy drugs as
single agents, and in combination with vitamin D analogs, in
the treatment of androgen-dependent and androgen-independent
prostate cancer in vitro and in vivo.
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Vitamin E anti-cancer effects
Studying the molecular mechanism of vitamin E in prostate cancer
cells, including the AR-PSA pathway, cell cycle regulation,
and the function of tocopherol associated protein (TAP), and
MMPs. Identifying vitamin E target genes in prostate cancer
cell lines using microarray and subtraction cloning techniques,
and analyzing the roles of these genes in vitamin E-induced
inhibition of cell proliferation in vitro and in vivo.
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View all of Dr. Chang's publications.
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