Developing Optimal Implant Designs & Surface Properties
Dental implants are widely used to replace missing teeth. Our research focuses on developing optimal implant designs and surface properties to improve wound healing events and to ensure a long lasting rehabilitation. In particular, we are interested in tailored approaches to create well defined topographical features with desired chemical composition. In addition to the development of novel surface modifications, our lab is focusing on the interplay between surface properties and wear during implant placement.
Surface Roughness Parameters as a Predictor of Wear During Implant Placement
Biomaterial surface modifications are used to trigger particular tissue responses. In common, most surface modification of metal implants will increase the roughness. The surface surface features created may not withstand the implant placement procedure and detach from the surface. Surface roughness parameters are used to provide numerical data to evaluate and estimate the overall release of particles from the implant surface.
Effect of Titanium Particles on Early Bone Loss
Early bone loss is a common finding after implant placement and is considered a normal event associated with wound healing. We have recently demonstrated that surgical sites pre-treated with Titanium particles demonstrated increased bone resorption resulting in early bone loss compared to control sites in the rabbit tibia. Our laboratory will investigate the mechanisms behind early bone loss triggered by titanium particles in vivo to establish novel approaches to prevent complications.
Environmental Agents and Oral Health
Mercury Vapor from Amalgam and Methylmercury Co-Exposure on Neurodevelopment
The aim of the project is to quantify the level of risk for adverse neurodevelopmental outcomes attributable to prenatal and postnatal co-exposure to mercury vapor from dental amalgam and methylmercury from fish consumption. This multinational collaborative project will capitalize on the availability of mothers and children participating in the well-characterized Seychelles Child Development Nutrition Study.
Award number: R01 ES015578
Principal Investigator: Gene E. Watson II, D.D.S., M.S., Ph.D.
Health Services Research
Oral Health Surveillance
To conduct oral health surveillance of preschool and elementary school children in collaboration with the Monroe County Department of Health.
Principal Investigator: Sangeeta Gajendra, D.D.S., M.P.H
Utility of Teledentistry to Reduce Oral Disease Burden in Preschool Children
An exploration of teledentistry, an approach that uses an intraoral camera to image teeth and tooth surfaces. To determine if teledentistry is useful in reducing oral disease burden in preschool inner city children, an intervention study will be conducted in inner-city childcare centers participating in Health-e-Access project.
Award number : K23 DE017230
Principal Investigator: Dorota Kopycka-Kedzierawski D.D.S., M.P.H.
Genetic basis of cleft lip and palate
Molecular genetic analysis of craniofacial development
Genetic reg. network in craniofacial development
Salivary Diagnosis and Therapy
Radioprotection by targeted SiRNA delivery to salivary glands
Salivary gland precursor cells
Skeletal, Alveolar and Dental Tissue Regeneration
Mammary stem cells in development and cancer
Periodontal Diagnosis and Therapy
Periodontal Diagnosis and Therapy
Implants, dental materials, lasers
Our Latest Research Publications
View our latest dental research publications
Center for Oral Biology