Close up of X8 Prospector I(µ)S microfocus sealed tube Cu(Kα) X-ray source, integrated optics, and APEX II CCD detector.
The Structural Biology & Biophysics Facility offers support services and access to state-of-the-art instruments to determine macromolecular X-ray crystal structures, and to investigate protein-protein, protein-nucleic acid, or protein-small molecule interactions.
The facility is a University of Rochester research resource located within the Department of Biochemistry & Biophysics. Our goal is to provide non-specialist and specialist users with access to biophysical instrumentation. More info...
High Resolution NMR Facility
Varian Unity INOVA 600 NMR spectrometer
The High Resolution NMR Facility houses a state-of-the-art Varian Unity INOVA 600 NMR spectrometer equipped with four RF channels, pulsed field gradient accessory and triple resonance probes. A GE Omega 400 (wide bore) spectrometer is also available in the facility. There are a few SGI andSUN Unix workstations available for data analysis and structure calculation. This facility is Located in the Department of Biochemistry & Biophysics, and is Directed by Prof. Scott Kennedy. In addition, the Chemistry department has a Varian Unity INOVA 500 spectrometer which is well suited for NMR studies of macromolecules, as well as an additional 500 MHz and two 400 MHz NMR spectrometers for student use. That facility is run by Prof. Thomas Krugh.
Electron Paramagnetic Spectrometer Facility
There are two research grade electron paramagnetic spectrometers (EPR) in the facility. A Bruker 200D-SRC with an X-band bridge has a wide bore magnet that accommodates a Janis cryostat. Sample temperature is continuously variable from 2K to 350K. Cavities are available for aqueous samples and electron nuclear double resonance (ENDOR) studies. A Varian E-12 spectrometer is equipped with both X- and Q-band bridges. Using a Janis cryostat, samples can be irradiated with x-rays, UV, or light and Q-band measurements taken at temperatures from 2K to 350K. This facility is located within the Bernhard Lab.
The Core Facilities provide services to all researchers at the University of Rochester School of Medicine and Dentistry. more info...
In addition to facilities individual faculty members have a variety of instrumentation that they make available for use
- Fermentation Reactors
- Beckman FX Liquid Handling Robots
- MicroCal Isothermal Titration Calorimeter (ITC)
- Cell Sorters (FACS)
- Computational Computing Cluster
- Fluorescence Polarimeters
- Light Scattering Photometers (dynamic/static)
- Circular Dichroism Spectrometer
- Confocal Microscopes