Ph.D. 1994 Iowa State University
Associate Professor of Genetics, Department of Biomedical Genetics (BMG)
We are interested in understanding the mechanisms controlling cell proliferation and survival in mammalian cells and how deregulation of these mechanisms contributes to cancer. Our work currently focuses on two research areas: function of cyclin E-Cdk2 substrate NPAT in mammalian cells, and signaling pathways regulating the proliferation/survival of B-cell lymphomas. We anticipate that these studies will ultimately lead to the development of new approaches for cancer treatment with high specificity and efficacy.
Kim, S-W., Oleksyn, D.W., Rossi, R., Jordan, C.T., Sanz, I., Chen, L., and Zhao, J. (2008) Protein kinase C-associated kinase PKK is required for NF-kB signaling and survival in diffuse large B-cell lymphoma cells. Blood 111, 1644-1653. View article in Blood
DeRan, M., Pulvino, M., Greene, E., Su, C., and Zhao, J. (2008) Transcriptional activation of histone genes requires NPAT-dependent recruitment of TRRAP-Tip60 complex to histone promoters during the G1/S phase transition. Molecular and Cellular Biology 28: 435-447. View article in PubMed
Su, C., Gao, G., Schneider, S., Helt, C., Weiss, C., O’Reilly, M., Bohmann, D., and Zhao, J. (2004) DNA damage induces down-regulation of histone gene expression through the G1 checkpoint pathway. EMBO J. 23:1133-1143. View article in PubMed
Graduate Program Affiliations
University of Rochester
601 Elmwood Ave.
Rochester, NY 14642
Office: MRB 2-9643
Current Lab Members