Zhao Lab
Jiyong Zhao
Ph.D. 1994 Iowa State University
Associate Professor of Genetics, Department of Biomedical Genetics (BMG)
Research Overview
We are interested in understanding the mechanisms controlling cell proliferation and survival in mammalian cells and how deregulation of these mechanisms contributes to cancer. Our work currently focuses on two research areas: function of cyclin E-Cdk2 substrate NPAT in mammalian cells, and signaling pathways regulating the proliferation/survival of B-cell lymphomas. We anticipate that these studies will ultimately lead to the development of new approaches for cancer treatment with high specificity and efficacy.
Projects
Recent Publications
Kim, S-W., Oleksyn, D.W., Rossi, R., Jordan, C.T., Sanz, I., Chen, L., and Zhao, J. (2008) Protein kinase C-associated kinase PKK is required for NF-kB signaling and survival in diffuse large B-cell lymphoma cells. Blood 111, 1644-1653. View article in Blood
DeRan, M., Pulvino, M., Greene, E., Su, C., and Zhao, J. (2008) Transcriptional activation of histone genes requires NPAT-dependent recruitment of TRRAP-Tip60 complex to histone promoters during the G1/S phase transition. Molecular and Cellular Biology 28: 435-447. View article in PubMed
Su, C., Gao, G., Schneider, S., Helt, C., Weiss, C., O’Reilly, M., Bohmann, D., and Zhao, J. (2004) DNA damage induces down-regulation of histone gene expression through the G1 checkpoint pathway. EMBO J. 23:1133-1143. View article in PubMed
Graduate Program Affiliations
Contact
Jiyong Zhao
University of Rochester
Box 633
601 Elmwood Ave.
Rochester, NY 14642
Office: MRB 2-9643
+1-585-273-1453
jiyong_zhao@urmc.
rochester.edu
Current Lab Members
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Mary Pulvino |
