Publications

Jiang Fu, Ming Jiang, Anthony J Mirando, H-M Ivy Yu and Wei Hsu.  Reciprocal regulation of Wnt and Gpr177/mouse Wntless is required for embryonic axis formation (2009). Proc Natl Acad Sci USA, In Press.

Wei Hsu, Anthony J Mirando and H-M Ivy Yu.  Manipulating gene activity in Wnt1-expressing precursors of neural epithelial and neural creast cells (2009). Developmental Dynamics: a special issue for Wnt signaling in development and disease, Published Online: Aug 3.

Ying Yan, Dezhi Tang, Mo Chen, Jian Huang, Jennifer H Jonason, Xiaohong Tan, David Reynolds, Wei Hsu, Stephen E Harris, J Edward Puzas, Hani Award, Regis J O'Keefe, Brendan F Boyce and Di Chen.  Axin2 controls bone remodeling through b-catenin-BMP signaling pathway in adult mice (2009). Journal of Cell Science, 122, 3566-3578. PDF

Sui Wang, Jan N Jensen, Philip A Seymour, Wei Hsu, Yuval Dor, Maike Sander, Mark A Magnuson, Palle Serup and Guoqiang Gu.  Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function (2009). Proc Natl Acad Sci USA, 106, 9715-9720. PDF

Shang-Yi Chiu, Naoya Asai, Frank Costantini and Wei Hsu.  SUMO-specific protease 2 is essential for modulating p53-Mdm2 in development of trophoblast stem cell niches and lineages (2008). PLoS Biology, 6(12): e310. PDF (Editor's Pick of the Week). Commentary in PLoS Biology: Sedwick C. Lessons on Life from SENP2 (2008). PLoS Biology, 6(12): e312. PDF

Bo Liu, H-M Ivy Yu, Jiaoti Huang and Wei Hsu.  Co-opted JNK/SAPK signaling in Wnt/b-catenin-induced tumorigenesis (2008). Neoplasia, 10, 1004-1013. PDF

Bo Liu, H-M Ivy Yu and Wei Hsu.  Craniosynostosis caused by Axin2 deficiency is mediated through distinct functions of b-catenin in proliferation and differentiation (2007). Developmental Biology, 301, 298-308. PDF

H-M Ivy Yu, Bo Liu, Frank Costantini and Wei Hsu (2007).  Impaired neural development caused by inducible expression of Axin in transgenic mice. Mechanisms of Development, 124, 146-156. PDF

H-M Ivy Yu, Bo Liu, Shang-Yi Chiu, Frank Costantini and Wei Hsu (2005).  Development of a unique system for spatiotemporal and lineage-specific gene expression in mice. Proc Natl Acad Sci USA, 102, 8615-8620. PDF

H-M Ivy Yu, Boris Jerchow, Tzong-Jen Sheu, Bo Liu, Frank Costantini, J Edward Puzas, Walter Birchmeier and Wei Hsu (2005).  The role of Axin2 in calvarial morphogenesis and craniosynostosis. Development, 132, 1995-2005. PDF

Wei Hsu, Reena Shakya and Frank Costantini (2001).  Impaired mammary gland and lymphoid development caused by inducible expression of Axin in transgenic mice.  Journal of Cell Biology, 155, 1055-1064. PDF

MA Julius, B Schelbert, Wei Hsu, E Fitzpatrick, E Jho, F Fagotto, F Costantini and J Kitajewski (2000).  Domains of axin and disheveled required for interaction and function in wnt signaling.  Biochem Biophys Res Commun, 276, 1162-1169.

Wei Hsu, Li Zeng and Frank Costantini.  Identification of a domain of Axin that binds to the Serine/Threonine Protein Phosphatase 2A and a self-binding domain (1999).  Journal of Biological Chemistry, 274, 3439-3445. PDF

Li Zeng, Francois Fagotto, Tong Zhang, Wei Hsu, Thomas J. Vasicek, William L. Perry III, James J. Lee, Shirley M. Tilghman, Barry M. Gumbiner and Frank Costantini (1997).  The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation.  Cell, 90, 181-192. PDF

Lydija Klampfer, Tae Ho Lee, Wei Hsu, Jan Vilcék and Selina Chen-Kiang (1994).  NF-IL6 and AP-1 cooperatively modulate the activation of the TSG-6 gene by tumor necrosis factor alpha and interleukin-1.  Molecular and Cellular Biology, 14, 6561-6569.

Wei Hsu, Tom K. Kerppola, Phang-Lang Chen, Tom Curran, and Selina Chen-Kiang (1994).  Fos and Jun repress transcription activation by NF-IL6 through association at the basic zipper region.  Molecular and Cellular Biology, 14, 268-276.

Wei Hsu and Selina Chen-Kiang (1993).  Convergent regulation of NF-IL6 and Oct-1 synthesis by interleukin-6 and retinoic acid in embryonal carcinoma cells.  Molecular and Cellular Biology, 13, 2515-2523.

Selina Chen-Kiang, Wei Hsu, Yasodha Natkunam, and Xiaokui Zhang (1993).  Nuclear signaling by IL-6.  Current Opinion in Immunology, 5, 124-128.

Jonathan M. Spergel, Wei Hsu, Shizuo Akira, Bayar Thimmapaya, Tadamitsu Kishimoto, and Selina Chen-Kiang (1992).  NF-IL6, a member of the C/EBP family, regulates E1A-responsive promoters in the absence of E1A.  J. Virol., 66, 1021-1030.