Goldman Lab

Current Projects

  • Glial progenitor-based cell therapy in myelin disease: pediatric leukodystrophies and multiple sclerosis
  • Tumor stem cells and gliomas of the adult CNS
  • Inducing endogenous progenitors as a means of treatment in Huntington’s disease
  • Use of human iPSC and ES cell-derived neural progenitors for drug development and disease modeling
  • Transcriptional and pathway regulation of progenitor cell types of both the fetal and adult human CNS

Recent Lab Publications

Goldman SA, Nedergaard M, Windrem MS. "Glial progenitor cell-based treatment and modeling of neurological disease." Science. 2012 Oct 26;338(6106):491-5.

McClain CR, Sim FJ, Goldman SA. "Pleiotrophin suppression of receptor protein tyrosine phosphatase-beta/zeta maintains the self-renewal competence of fetal human oligodendrocyte progenitor cells." J. Neurosci.32:15066-75, 2012.

Iliff JJ, Wang M, Liao Y, Plogg BA, Peng W, Gundersen GA, Benveniste H, Vates GE, Deane R, Goldman SA, Nagelhus EA, Nedergaard M. "A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid beta." Science Transl. Med. 4:147ra111, 2012.

Benraiss A, Bruel-Jungerman E, Lu G, Economides AN, Davidson B, Goldman SA. "Sustained induction of neuronal recruitment to the adult rat neostriatum by AAV4-delivered noggin and BDNF." Gene Therapy, 19:483-93, 2012.

Goldman SA, Chen Z. "Perivascular instruction of cell genesis and fate in the adult brain." Nature Neuroscience 14:1382-89, 2011.

Benraiss A, Goldman SA. "Cellular therapy and induced neuronal replacement for Huntington's disease." Neurotherapeutics 8:577-590, 2011.

Sim FJ, McClain CR, Schanz SJ, Protack TL, Windrem MS, Goldman SA. "CD140a identifies a population of highly myelinogenic, migration-competent and efficiently engrafting human oligodendrocyte progenitor cells." Nature Biotechnol. 29:934-941, 2011.

Goldman SA. "Progenitor cell-based treatment of pediatric myelin disorders." Arch. Neurology, 68:848-56, 2011.

Persson AI, Petritsch C, Swartling FJ, Itsara M, Sim FJ, Auvergne R, Goldenberg DD, Vandenberg SR, Nguyen KN, Yakovenko S, Ayers-Ringler J, Nishiyama A, Stallcup WB, Berger MS, Bergers G, McKnight TR, Goldman SA, Weiss WA. "Non-stem cell origin for oligodendroglioma." Cancer Cell, 18:669-682, 2010.

Bugiani M; Boor I; van Kollenburg B; Postma N; Polder E; van Berkel C; van Kesteren RE; Windrem MS; Hol EM; Scheper GC; Goldman SA; van der Knaap MS. "Defective glial maturation in vanishing white matter disease." Journal of neuropathology and experimental neurology. 2011; 70(1):69-82.

Goldman SA. "Progenitor Cell-Based Treatment of the Pediatric Myelin Disorders." Archives of neurology. 2011; Epub 2011 Mar 14.

Hertz, L., Lovatt, D., Goldman, S.A. Nedergaard, M. "Adrenoceptors in brain: Cellular gene expression and effects on astrocytic metabolism and intracellular calcium". Neurochem Int.. 2010; 57(4): 411-420.

Zhang, S., Li, B., Lovatt, D., Xu, J., Song, D., Goldman, S.A., Nedergaard, M., Hertz, L., Peng, L. "5-HT2B receptors are expressed on astrocytes from brain and in culture and are a chronic target for all five conventional 'serotonin-specific reuptake inhibitors'." Neuron Glia Biol.. 2010; 6(2): 113-125.

Wang, S., Chandler, D., Lu, G., Auvergne, R., Geschwind, D., Coppola, G., Nicolis, S., Sim, F., Goldman, S.A. "Prospective identification, isolation, and profiling of a telomerase-expressing subpopulation of human neural stem cells, using sox2 enhancer-directed fluorescence-activated cell sorting." J Neurosci.. 2010; 30(44): 14635-14648.

Persson AI; Petritsch C; Swartling FJ; Itsara M; Sim FJ; Auvergne R; Goldenberg DD; Vandenberg SR; Nguyen KN; Yakovenko S; Ayers-Ringler J; Nishiyama A; Stallcup WB; Berger MS; Bergers G; McKnight TR; Goldman SA; Weiss WA. "Non-stem cell origin for oligodendroglioma." Cancer cell. 2010; 18(6):669-82.