Recent Publications
Cell and Gene Therapy
Goldman SA, Nedergaard M, Windrem MS. "Glial progenitor cell-based treatment and modeling of neurological disease." Science. 2012 Oct 26;338(6106):491-5.
McClain CR, Sim FJ, Goldman SA. "Pleiotrophin suppression of receptor protein tyrosine phosphatase-beta/zeta maintains the self-renewal competence of fetal human oligodendrocyte progenitor cells." J. Neurosci.32:15066-75, 2012.
Iliff JJ, Wang M, Liao Y, Plogg BA, Peng W, Gundersen GA, Benveniste H, Vates GE, Deane R, Goldman SA, Nagelhus EA, Nedergaard M. "A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid beta." Science Transl. Med. 4:147ra111, 2012.
Benraiss A, Bruel-Jungerman E, Lu G, Economides AN, Davidson B, Goldman SA. "Sustained induction of neuronal recruitment to the adult rat neostriatum by AAV4-delivered noggin and BDNF." Gene Therapy, 19:483-93, 2012.
Goldman SA, Chen Z. "Perivascular instruction of cell genesis and fate in the adult brain." Nature Neuroscience 14:1382-89, 2011.
Benraiss A, Goldman SA. "Cellular therapy and induced neuronal replacement for Huntington's disease." Neurotherapeutics 8:577-590, 2011.
Sim FJ, McClain CR, Schanz SJ, Protack TL, Windrem MS, Goldman SA. "CD140a identifies a population of highly myelinogenic, migration-competent and efficiently engrafting human oligodendrocyte progenitor cells." Nature Biotechnol. 29:934-941, 2011.
Goldman SA. "Progenitor cell-based treatment of pediatric myelin disorders." Arch. Neurology, 68:848-56, 2011.
Persson AI, Petritsch C, Swartling FJ, Itsara M, Sim FJ, Auvergne R, Goldenberg DD, Vandenberg SR, Nguyen KN, Yakovenko S, Ayers-Ringler J, Nishiyama A, Stallcup WB, Berger MS, Bergers G, McKnight TR, Goldman SA, Weiss WA. "Non-stem cell origin for oligodendroglioma." Cancer Cell, 18:669-682, 2010.
Bugiani M; Boor I; van Kollenburg B; Postma N; Polder E; van Berkel C; van Kesteren RE; Windrem MS; Hol EM; Scheper GC; Goldman SA; van der Knaap MS. "Defective glial maturation in vanishing white matter disease." Journal of neuropathology and experimental neurology. 2011; 70(1):69-82.
Goldman SA. "Progenitor Cell-Based Treatment of the Pediatric Myelin Disorders." Archives of neurology. 2011; Epub 2011 Mar 14.
Hertz, L., Lovatt, D., Goldman, S.A. Nedergaard, M. "Adrenoceptors in brain: Cellular gene expression and effects on astrocytic metabolism and intracellular calcium". Neurochem Int.. 2010; 57(4): 411-420.
Zhang, S., Li, B., Lovatt, D., Xu, J., Song, D., Goldman, S.A., Nedergaard, M., Hertz, L., Peng, L. "5-HT2B receptors are expressed on astrocytes from brain and in culture and are a chronic target for all five conventional 'serotonin-specific reuptake inhibitors'." Neuron Glia Biol.. 2010; 6(2): 113-125.
Wang, S., Chandler, D., Lu, G., Auvergne, R., Geschwind, D., Coppola, G., Nicolis, S., Sim, F., Goldman, S.A. "Prospective identification, isolation, and profiling of a telomerase-expressing subpopulation of human neural stem cells, using sox2 enhancer-directed fluorescence-activated cell sorting." J Neurosci.. 2010; 30(44): 14635-14648.
Persson AI; Petritsch C; Swartling FJ; Itsara M; Sim FJ; Auvergne R; Goldenberg DD; Vandenberg SR; Nguyen KN; Yakovenko S; Ayers-Ringler J; Nishiyama A; Stallcup WB; Berger MS; Bergers G; McKnight TR; Goldman SA; Weiss WA. "Non-stem cell origin for oligodendroglioma." Cancer cell. 2010; 18(6):669-82.
Glial Disease and Therapeutics
Wang M, Iliff J, Liao Y, Chen MJ, Shinseki M, Venkataraman V, Nedergaard M. (2012) "Cognitive deficits and delayed neuronal loss in a mouse model of multiple microinfarcts." J Neurosci. 2012 Dec 12;32(50):17948-60.
Iliff JJ, Nedergaard M. (2012) "A link between Glial Ca(2+) signaling and hypoxia in aging?" J Cereb Blood Flow Metab. 2012 Dec 5.
O'Donnell J, Zeppenfeld D, McConnell E, Pena S, Nedergaard M. "Norepinephrine: A Neuromodulator that Boosts the Function of Multiple Cell Types to Optimize CNS Performance." Brain Res. 2012 Dec 3;1487:3-15.
Cotrina ML, Nedergaard M. (2012) "Brain connexins in demyelinating diseases: Therapeutic potential of glial targets." Brain Res. 2012 Dec 3;1487:61-8.
Wang F, Xu Q, Wang W, Takano T, Nedergaard M. (2012) "Bergmann glia modulate cerebellar Purkinje cell bistability via Ca2+-dependent K+ uptake." Proc Natl Acad Sci U S A. (2012)15;109(20):7911-6
Lovatt D, Xu Q, Liu W, Takano T, Smith NA, Schnermann J, Tieu K, Nedergaard M. (2012) "Neuronal adenosine release, and not astrocytic ATP release, mediates feedback inhibition of excitatory activity." PNAS 109(16):6265-70.
Messing A, Brenner M, Feany M, Nedergaard M, Goldman J. (2012) "Alexander Disease." J. Neurosc. 32(15):5017-5023.
Wang F, Smith N, Xu Q, Fujita T, Baba A, Matsuda T, Takano T, Bekar L, Nedergaard M. (2012) "Astrocytes exert widespread control of neuronal activity by active regulation of extracellular K+." Sci. Signal. 5, ra26.
Verkhratsky A, Sofroniew M, Messing A, deLanerolle NC, Rempe D, Rodriguez J, Nedergaard M. (2012) "Neurological diseases as primary gliopathies: A reassessment of neurocentrism." ANS Neuro (4): 3.
Torres A, Xu Q, Wang F, Fujita T, Dobrowski R, Willecke K, Takano T, Nedergaard M. (2012) "Extracellular Ca2+ acts as a mediator of communication from neurons to glia." Sci. Signal. 5, ra8.
Huang C, Han X, Li X, Lam E, Peng W, Lou N, Torres A, Yang M, Mauricio Garre J, Tian G-F, Bennett M, Nedergaard M, Takano T. (2012) "Critical role of connexin 43 in secondary expansion of traumatic spinal cord injury." J. Neurosci. 7;32 (10):3333-8.
Nedergaard M, Verkhratsky A. (2012) "Artifact versus reality—How astrocytes contribute to synaptic events?" Glia. 60(7):1013-23.
Oberheim NA, Goldman S, Nedergaard M. (2012) "Heterogeneity of astrocytic form and function." Methods Mol Biol. 814:23-45.
Fujita T, Williams EK, Jensen TK, Smith NA, Takano T, Tieu K, Nedergaard M. "Cultured astrocytes do not release adenosine during hypoxic conditions." J Cereb Blood Flow Metab. 2011; Epub 2011 Oct 12.
Christensen DJ, Nedergaard M. "Two-photon in vivo imaging of cells." Pediatric nephrology (Berlin, Germany). 2011; Epub 2011 Mar 15.
